The 3-Shot HBV Vaccine – Do I Need to Restart the Series if I Am Off the Recommended Schedule?

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The Hepatitis B vaccine is a safe and effective 3-shot series that protects against HBV.  If you have HBV, the vaccine will do you no good, but if you do not have HBV, vaccination is a great way to protect yourself. The recommended schedule for the hepatitis B vaccine is to receive the first shot, followed in one month by the second shot.  Six months following the first shot, you should receive your third and final shot of the series. If you are committed to ensuring that you have built up adequate immunity, you can have your anti-HBs (HBsAb) titres checked 4-6 weeks following the last shot of the HBV vaccine series.  If your immunity is greater than 10 IU/l, then you have adequate immunity which is thought to confer lifetime immunity, but studies so far show 20 years.  This is because these studies are on-going!  Please note that checking anti-HBs titres is not generally recommended for all vaccine recipients, with the exception of those that might be at greater risk of infection.   This includes but is not limited to health care workers, those with sexual partners with HBV, and those living in a household where someone is infected with hepatitis B. Talk to your doctor if you think you might be at higher risk and need to have your titres checked.

So what happens if you go for shot one, followed by shot two in a month, but you never get to shot three?  The minimum length of time between the three shots in the series is what is noted above: 0, 1 month, and 6 months.  There is an accelerated schedule, but this is the schedule recommended for the shortest amount of time, with the best immune response for the general population.  However, if you don’t get to shot three of the series for another two years, or if you never got to shot two, you can resume right from where you left off, and continue without the need for repeating the series. Once again if you would like to ensure that you have adequate immunity, you can have your anti-HBs titres (HBsAb) checked 4-6 weeks following the last shot of the series to be sure it is greater than 10 IU/l.

What happens if you don’t have your vaccine records, and you have no idea if you ever got shot 1 or 2, and you just want to repeat the series? There is no concern with repeating the HBV vaccine series, so if you are unsure, please start the series from shot 1.

Be sure you and your loved ones vaccinated are against hepatitis B so you can be HBV free for life!

302 Responses to The 3-Shot HBV Vaccine – Do I Need to Restart the Series if I Am Off the Recommended Schedule?

  1. Very informative information to help safeguard our loved ones!

  2. Hello! im 13 years old and i am not going to get the jag what will happen to me if i dont and what if i decide to get the jag after leaving high school is that possible p.s Please reply fast please im so worried

    • Hello, The hepatitis B vaccine is a 3-shot series. My daughters will tell you that the it only hurts while you’re getting the shot. One prefers to watch so she knows when it’s going in and the other daughter prefers to have her eyes closed! it is well worth a few minutes of discomfort if you can be protected against hepatitis B for life. Often there are no symptoms when you are first infected with HBV, but it can cause serious liver damage in the future and puts you at much greater risk for liver cancer. So please don’t worry too much about your HBV vaccination and try to think of it as a good thing!

  3. I am getting ready to travel out of the country. I have received the first round of the Hep B shot. I will be leaving in just under a month from the first shot. Is it better to get the second shot just before I go to be more protected that way, which will be just under a month, or am I better off to give the first shot the extra time to do what it needs to do?

    • The time in between shots in the series is the minimum amount of time, so if you got your shots in the series early, you may not be adequately protected. If the time between injections is greater than that of the schedule, then you are fine and do not need to start the series over. If you have concerns with the immunity generated, you can ask that your doctor run an anti-HBs titre test 1-2 months following the last shot of series. If your titres are greater than 10 then you are protected.

  4. Hi! My live in boyfriend for four years is positive of hepa b. He had it more than 10 yrs ago but haven’t took any vaccine or any medication. Can he still be cured if he will have the shots? Also, I had my hepa A and B vaccine with complete 3 shots. Will I still be at risk for getting it even I had the doses? I’m really nervous. Thanks.

    • It is important to know if your boyfriend had an acute infection 10 years ago that he resolved, or is he currently infected? If he resolved his HBV infection and has antibodies (HBsAb) then he is not infectious to you or others. Since you have been vaccinated against HBV , you should be protected against any exposure. Encourage your boyfriend to have a hepatitis B panel so he can see for sure that his infection is resolved. It’s one blood draw, but 3 tests that will let him know if he is currently infected, previously infected and whether or not he generated an adequate antibody response.

  5. Hi there, if I got my second dose May 2006 but never received my third shot, should I restart the series? (I do have lab test results showing my immunity)

    Thanks!

    • You do no need to repeat the series. Get your third shot of the series now and you will be good. If you have concerns regarding immunity generated, you can always choose to have an anti-HBs titre test 4-8 weeks following this last shot of the series. if your titre is above 10, then you are protected. This is not standard, but only if you have specific concerns.

  6. Hi, what if I’m only able to get shots 1 and 2 completed before I travel. Will I still be protected?

    • Following shot 2 of the series, you will have up to 85% protection generated, so you should be good. Just take basic precautions while traveling – not only for HBV, but for other infectious agents. Don’t forget to get your 3rd HBV shot on schedule after your return so you are sure to generate protective antibodies.

  7. Is there a max time frame to get shot 3 from the time shot 2 was administrated? I have an employee that received shot 2 over ten years ago, can he just get shot 3 now or would it be best to start over? We have documented proof of shot 1 and shot 2.

    Thank you.

    • The time noted on the schedule is the minimum time in between shots in the series. Since you are sure he has had shot 1 and 2, he can go on to get shot 3 despite the length of time.

  8. Hi, i just had my 1st shot of vaccine today before i took hepatitis B test. is it true that i will be more likely to have a positive result? i took the hep test 2hrs and a half passed when i had the vaccine. pls reply asap.

    • False-positive HBsAg results can occur during the postvaccination period. Transient antigenemia of up to 4 weeks has been reported. Interpreting the result during this period should be made with caution. If possible, testing for HBsAg within 4 weeks after HBV vaccination should be avoided.

  9. So it means the result i just had with the vaccination with the hepatitis test on that same day will be more likely negative?? pls i need the answer back..thx

  10. If you had an HBsAg test, or hepatitis B surface antigen test then it is possible it will be positive, which could be a false positive because you were just vaccinated. If your HBsAg result it negative, then it is negative. Be sure to keep copies of your test results so you can confirm your results.

  11. I see, then when can i possibly take the next Hepatitis Test that will give me real result?

  12. A month after the shot. Don’t worry if you would prefer to extend your time between the 1st and 2nd shot. The time on the schedule is the minimum amount of time in between injections in the series. Next time have the blood drawn first before getting your shot.

  13. Thank you so much for the advice and answering my questions :) I just called the Diagnostic Center and my result came out NEGATIVE. I was really worried because i might fail my medical and my work is on the line here. Next time i’ll ask my doctor first before taking any vaccine.

  14. my wife has chronic hepatitis B since years back ,and i have completed my three dose vaccine . am i protected fully even if i have direct blood contact?

    • Assuming you generated adequate immunity as a result of your 3 shot vaccination series, you are good. However, if it will put your mind at ease, ask your doctor to test you for HBV.

  15. If 1st hep b vaccination of 0,1,6 is taken on 19 nov.2012. 2nd should be taken between which dates from 19 dec. to 25 dec. 2012 and what should be 3rd ones date? pl. reply at earliest.

    • The shortest time between shot 1 and shot 2 is one month. You can get shot 2 after 19 December. Shot 3 is should be given 6 months after shot 1.

  16. What if you have gotten your 1st & 2nd hep B shot, but you need your 3rd shot before 6months to meet a deadline, can you get the 3rd shot? What are the risks of getting your 3rd shot earlier? 2.5 months after 1st shot

    • You may not generate adequate immunity. Every person’s immune response varies. If you want to confirm your immunity when you get back from your trip or if you’re doing it for work, then I would encourage you to get an anti-HBs titre run to ensure that you have generated adequate immunity. It should be run 1-2 months after your last injection and it should be greater than 10 IU/ml.

  17. If I had all 3 shots in the series years ago (1999) do I have to have them again since I am starting a job in a health related field?

  18. hello! I am a nurse. i have my 3 shots of HBV and i also have my booster . so this is the case ,few weeks ago i was asked to clean the instruments used for Cesarean section operation which are being used to a hep B positive patient and i have a wound that time i am not sure if i had a splash of blood on it i am so worried that i would be infected. please reply..

    • Hello. You should be in good shape since you had your vaccine series and a booster shot, but if you did not run an anti-HBs titre, one month to two months after your last booster shot or the last shot of your 3 shot series, then you can have can one run now. You should get your results back in a day and that will alleviate your concerns. Your titres should be above 10 IU/ml. Please try not to worry. If you’d like you can send me the results if you have any concerns.

  19. Hello, If i am required to take the 3shot Hep B vaccination for a medical office job and only took the 1st shot, what are my risk of working with patients and blood?

    • After the first dose of the vaccine you will generate up to 50% protection against HBV. After the 2nd shot of the series, there is up to 80% protection. I would encourage you to get the 2nd and then the third shot to complete the series. The 1 month between shot 1 and 2 may be any length greater than 1 month, so if that is your concern, you do not need to re-start the series. if you will be working with patients and blood, it is important that you be protected against HBV.

  20. I had the HBV Vaccine 4 years ago and last week I did a hep blood test, the hep b core ab came back positive/ negative and the hep b surface antigen came back negative/ negative.. So do I have it or not?

    • It sound like you may have had HBV and resolved the infection prior to being vaccinated, though you do not mention if your HBsAb is positive or negative. The positive HBcAb in the presence of a negative HBsAg indicates a previously resolved infection. Your HBsAb should also be positive. This would indicate that you have immunity to HBV.Without a previous infection and vaccine, a positive HBsAb would indicate immunity as a resolve of vaccination. If you do not know if you are HBsAb pos or neg, then you need to be sure to have this test run.

  21. Ok. She did a hep profile chronic ,undifferentiated and it just gave the core and antigen results.

  22. how many shots of anti hbs to take if i have hepa b?thanks

    • I am not sure of your question. The HBV vaccine is a 3 shot series given at month 0, 1 month, and 6 months. The anti-HBs titre is run to determine if you have generated adequate immunity as a result of the vaccine series.

  23. hi,way back 2008 I had my 1st & 2nd dose of hepb vaccine but got my 3rd shot earlier than 6 mos fr my 1st shot. Sept 2012 I was again able to get a booster shot from the healh company I work in.only this dec of last year I started working as a private nurse to a chronic hepb +patient and part of my job is to check his blood glucose daily.i m worried that I am in constant contact with things he uses and he probably could have transferred a little blood fr his fingers on it. I sometimes had small wounds on my hands but cant keep that latex gloves worn the whole time.i want to ask if those shots i mentioned are adequate enough to protect me from being infected. Thanks.

    • You are most likely good, but I think the best way to alleviate your concerns about your HBV immunity is to have your anti-HBs titres checked. If your anti-HBs titre is equal to or greater than 10 IU/ml, then you have adequate immunity. If it is below 10 IU/ml, you may still have immunity due to immune memory, but I would encourage one more booster shot if below 10 and then have your anti-HBs titres checked 1 month following the booster shot. If it’s above 10 IU/ml, then you know you are protected.

  24. Thanks for the response. I got another question though, i had my titre test done a month after the last dose. The medical technician informed me that i got 0% generated/detected result and he said i am 0% protected and got 0% immunity. How possible is that where in fact i already got a series of shots and recently had my boosters last sept 13 followed by nov 22 and had my titre done on december 25? Thanks

  25. Hi…. i am hep b positive… i have a boyfriend and we’ve been together for 7 years.. i fear that i had my boyfriend infected with hep b.. actually he already had 2 shots but that was 7 years ago and still up to now he did’nt get to have his third shot… help me please…..,

    • You need to talk to your boyfriend about your HBV. He needs to be tested and if he is not infected, then he needs to complete the vaccine series. Please be sure you are being monitored by a liver specialist about your HBV.

  26. help! what if my girlfriend got his one shot hepa vaccine only and then we’ve got a blood contact. Am i protected somehow? or will i got the virus also? And does it have a situation like you have a sex contact with chronic hepa b for several time but you have a good immune system, can you get the infection easily? please help, im nervous. thank you

    • Hepatits B is transmitted through direct contact with HBV infected blood and body fluids, which means it is also a sexually transmitted disease. If you have not completed the vaccine series and you believe you have been exposed, then you need to be tested. If you do not have HBV, then I would encourage you to complete the HBV vaccine series.

  27. is it right not to tell your bf or gf that you have chronic hepa b? im afraid im gonna lose the relationship? :(

    • I know it is hard, but I think it’s the right thing to do. Don’t you believe your boyfriend will eventually learn of your HBV? Look through these blogs and our website (www.hepb.org) so you can learn the basics about your HBV. Have some information available for him to refer to about HBV so he can learn.

  28. can you recommend a liver specialist in toronto? i hope it wont be expensive that much. thank you

  29. Hi, I know I have had HEB vaccines before but my granma lost my birth immunization card. Is there a risk in taking more than 3doses?

    • There is no risk in getting the vaccine repeated if you need the vaccine for your records. An alternative would be to have your anti-HBs titres checked and if it is above 10 IU/ml, then you have generated adequate immunity. However, check to see if they are willing to take the titre as a substitute for the repeated vaccine series. They should, but that doesn’t mean they necessarily will.

  30. hi my husband have hbsag positive.i took vaccine shot 1 jan 17 th then i will take my next shot feb 17 th . i am planing to get concieve(pregnent)if i will concieve is it safe to take 3rd shot ? we are in more confusion plz solvemy problam

    • The vaccine is safe to have even if you are vaccinated while you are pregnant. Have you been tested to be sure that your husband did not transmit HBV to you prior to vaccination? Please check with your doctor.

  31. I am about to start taking classes for a health field, and we are required to have HB vaccinations. If I got it when I was an infant, do I have to get a whole new round, a booster, or am I still protected?

    • Everyone is a little different, but most likely you are protected. However, you will need to have your anti-HBs titres checked so you can confirm you have adequate immunity. Ask your doctor to run an anti-HBs titre test and if it is 10 IU/ml or above, then you have adequate protection. If not, then you should get a booster shot. One month following the booster shot, you will want to repeat the anti-HBs titre test. If it is 10IU/ml or above you are good. If it’s below, then complete the series and repeat the titre. That being said, you will want to see what your school is going to require – proof of vaccination, or proof of immunity. If your job will put you at risk then I would encourage you to have the anti-HBs titre test to confirm immunity.

  32. Hello,
    I am getting ready to start medical school in a few months. I did a titer count and found out that I have no immunity for Hep B. It looks like I had my first shot in 1998. I got my second one a week ago on 1/23/13 and the third is scheduled for 3/23/13 (two months). The nurse at the public health department said I didn’t have to restart the series. However, when I asked the school nurse at my college, she said I had to restart from the first shot since the first one was back in 1998. Who is correct?

    • The Health Department nurse is correct. You do not need to restart the series. The time in between shots in the series is the minimum amount of time necessary to generate adequate immunity.

  33. How much protection is there from just one shot?

  34. I’m HbsAg positive (Reading says >250 IU/ml). And my HBV-DNA test says 91 IU/ml (1.96 Log value). My wife is HbsAg Negative and she got 2 out 3 HepB vaccine(Engerix) shots (0, 1 month).

    1. How safe is to have sex(Unprotected) after 2 doses? If it is not safe now, when exactly she would be completely protected?
    2. What treatment is recommended (Oral Medicine or Interferon)? We consulted couple of doctors and we got different opinions.
    3. Any other precautions I/my wife has to take?

    • After 2 shots of the 3 shot HBV vaccine, your wife has UP TO 80% protection. I would encourage that you practice safe sex until she has completed the series. She can also have an anti-HBs titre run 1 month after the last shot of the series to ensure she is adequately protected. However, I will say that your HBV DNA viral load at the time of the test was low, so you were not highly infectious at that time. Be sure to avoid sharing personal hygiene items that may have traces of infected blood on them such as razors, toothbrushes or nail clippers. Was your wife screened for HBV to be sure she was never infected? Talk to your doctor about whether treatment is a good option at this time. You may want to be closely evaluated and monitored to see if there is a change in your viral load, ALT going up and down, family history, HBe positive or negative HBV?

  35. I received my first shot in November, second shot in December and the last in June. I am being told that because the second shot was 4 days short of 1 month it doesn’t count. Any thoughts?

    • The time in between shots in the series is the minimum amount of time. However, the fact that you were off by a couple of days is hard to know for sure if you will be able to generate adequate immunity. Everyone’s immune system is a little different. An extra shot will not hurt you, so if you believe the shortened time in between shots 1 and 2 will be an issue, then you can repeat it. One month after the 3rd shot in the series you can have an anti-HBs titre test run to see if you have generated adequate immunity. If your levels are below 10IU/ml, then you will want to get a booster shot. Once again you can confirm immunity with a follow up titre test one month later.

  36. Could you comment a little more about the “accelerated series?” I may be in need of that as I am currently awaiting titer results; however, it’s very important that it say I have immunity. I’m supposed to start rotations in July for medical school and if I need to restart the series, that’s going to cut into my first rotation and I might have to delay starting clinicals, which would be very disappointing. I really hope I have immunity, so that I don’t have to deal with this! Thanks for your help and this website.

    • It sounds like you have completed the series and you are concerned that you may not have generated adequate immunity? if that is the case you can get a booster and then have the anti-HBs titre run 1 month after the booster. That should do it, but if you do not generate adequate immunity you can literally repeat the series one shot at a time followed by titre testing one month later. There are also accelerated schedules. You can do 0, 1 month, 4 months, or you can even try: Day 0, Day 7, Day 21 – this should provide adequate immunity but you will need a booster dose at MONTH 12. Don’t forget titre testing. In your situation, that’s important.

  37. I had hep b when i was little do i need to get the shots or does it matter . or will i get it again if i dont get the shots?

    • If you have or have had HBV then you do not need to be vaccinated. The vaccine does nothing for those already infected or previously infected. Are you sure you resolved your childhood infection? If you dont’ know for sure, please talk to your doctor about running a hepatitis B panel to confirm.

  38. My husband is hep positive, I had receive all 3 doses of hep b vaccine before I met my husband, I tested negative after he was diagnosed..I have immunity when my doctor checked my titter levels last year. Does it matter if I recently this year got an extra dose of the hep b vaccine by mistake? It was a medical error and am worried I will now be less immune. Will that hurt my already immunue system to hep b? or do I need to continue the series so I would continue to be immune. I guess my worry is due to the random one dose would I become less immune? Also, being that I a at continue exposure to hep b from my husband positive status, do I at any point need a booster shot, how often should I check my immunity level. Am I immune for life….

    • Your extra shot would be considered a booster shot and it will not hurt you. If you want to ensure that your immunity generated is adequate, you can ask your doctor to run an anti-HBs titre test 1-2 months following your booster shot. If your levels are above 10 IU/ml then you are protected and should be good 20+ years – the number of years tracked in vaccine studies. If you do not generate immunity following your booster shot, you can continue with the series and test (anti-HBs titre) 1 month after the last shot of the series.

  39. Do they test for Hep B before giving Hep B series vaccine? I want to confirm that if a person has completed the series vaccination they are negative for Hep B.

    • It is not standard to test someone for HBV prior to vaccination. However, you can always have a hepatitis B panel run before vaccination to confirm the person does not have HBV . If you are concerned that someone that is already vaccinated has HBV then you can still run the hepatitis B panel to see if they have a current or previous infection, or if they have immunity from the vaccine or from a previous infection (HBsAg, HBcAb, HBsAb)

  40. my child one year old need to shot hep b vaccine as i am a hep b carrier;she has done a few shorts before. can i delay for one month as she is in overseas now///

    • Hopefully your child was vaccinated within 12 hours of birth and was also able to receive a shot of HBIG at the same time, since you are a HBV carrier. Extending the time in between shots in the HBV vaccine series is okay. Shortening them is not okay. Please be sure your child is tested for HBV at 18 months.

  41. I had my HBV… my first shot is in january 22 and my 2nd shot in february 22… The problem is I accidentally had sex unprotected to my GF with HEB positive this week…
    Am I protected of those 2 shots?
    what should I do?
    Im so scared now… Please help…

    • After 2 shots of the HBV vaccine series you have UP TO 80% coverage. Did you talk to your doctor? Prophylaxis is available, but it is really only effective in the first 48 hours. Since you are beyond that, you should get a hepatitis B panel 4-6 weeks after having sex with your girlfriend since there is a window before you would actually test positive, if you were infected. Please be sure to have protected sex until you have been tested and until you have your 3rd shot of the series. Take basic precautions to avoid transmission to others.

  42. I recived my Hep B shots in November is there a chance that I would come up with positive test results after getting the shots? I was not positive before I got my shots.

    • If you were tested within a month of one of the shots of the series, it is possible you will generate a false positive. I’m not clear on the timing of your labs and the timing on shots in the series, but I would encourage you to wait a month and get re-tested. You cannot get hepatitis B from the vaccine, but if you happened to be infected prior to receiving the vaccine, it will not help and you would test positive. Please retest to clarify.

  43. my child got vaccinated at 0,1,3 months for hepatitis virus, which is not as per the schedule. now can he get vaccine at 6th month or not

    • Unfortunately your child received the final shot of the series too soon. The time in between shots is the minimum amount of time. He/she will likely not generate adequate immunity so move forward with the 3 shot of the series at month 6.

  44. I am reading these posts hoping and praying that these folks have been properly informed that just because youve had these shots doesnt mean you cannot get it.I took the shots myself.Idrove a school bus for handicap children it was required of me.I Couldnt believe me ears when this doctor told me this.Im still being treated with viread this medaacine makes me so evil.Moody you name it.I was remarried you see Sept.5th 2013.and i took my new husband to the doctor with me,You could only imagine my shame.I never ever used a needle.The only way i could have caught it was unprotected sex or by one of the 2 blood transfusions i had in 1987 or 1993,.PLEASE do not be uninformed.I will tell you i sit here sick today i took the HBV vaccinations.

    • I am very sorry to hear of your chronic HBV infection. The HBV vaccine is very effective, but there is a certain percentage of the population that are non-responders to the vaccine. This happens with all vaccines. The other possibility is that you were infected before you received the HBV vaccine series. The vaccine is not effective for those already infected. It may be impossible for you to determine the source of your infection. Please know that there is no shame in having this virus. However, having a chronic illness, and one that often has a stigma associated with it can be difficult to cope with.

  45. Hi!.. I’m not sure if I received 2 or 3 doses of hep b vaccine because I’ve lost my vaccination records.. it has been 8 years more or less since I got those shots.. I had my antiHBs titers since its required in my univ.. my result is 22mlU/mL… so i still need a booster dose? or should i start the vaccine over again since i cant remember if i completed 3 doses?
    I’ve seen that above 10 mIU/ml means ur protected.. does my result show that I actually finished the 3 doses?

    I hope to hear from you soon!

    • Your anti-HBs titres look good. If your titre is above 10 IU/mL, you have adequate protection. You do not need a booster shot, nor do you need to repeat the series. The titre should be adequate to show proof of immunity at your school.

  46. if i had the first and second shot can i be infected if i have sex with an infected person?

    • It’s impossible to say. After 2 shots of the series you generate UP TO 80% immunity. However, everyone’s immune system is different. I would encourage you to get the 3rd shot of the series. You might also want to consider getting tested prior to vaccination.

  47. I was wondering, I got my first shot in Oct 25, 2012 and they rescheduled me to come in for my 3rd shot in February 25, 2013. I just got the shot, but now I was just informed that I was supposed to get my 3rd shot 6 months after my first shot… Are there any effects if I got the shot too early? About 2 months early? Thank you.

    • There is no danger in getting the vaccine early. I’m not sure of the timing of all 3 shots of the series that you received, but it is possible that you will not generate adequate immunity. You can determine this by getting an anti-HBs titre test 1-2 months following the last shot of the series. If it’s above 10 IU/mL, then you are protected, If not, you need to get a booster shot. The additional shot will not hurt you.

  48. I got the three shot series, checked my titer and it was less then 0.5, then got a booster shot, my titer remained low and has been low since then. What do I do?

  49. what happen if i forgot to take my third dose of hepatitis b ? is any harm and infection with that?

    • You need to complete the series by getting the third and final shot. It does not matter that it has been a long time. If you believe you were exposed to HBV, please know that you were not fully protected with the 2 shots of the vaccine series. Consider being screened for HBV prior to the 3rd and final shot.

  50. If you got tested all the time the doctor said you don’t have hepatitis b can you get it from your partner that have a positive result later in the future plz answer me

    • I’m not quite sure I understand your question. if you have a partner with HBV you really need to get the HBV vaccine series to protect you against HBV from infected blood or body fluids. You have been very fortunate to not get infected. It is possible that your partner is currently in the inactive phase and not as infectious. However, that can change, and you would not be aware of it. We are so fortunate to have a vaccine available to protect against hepatitis B. Please get vaccinated!

  51. I plan on starting a Phlebotomy program just as soon as i finish my hepatitis B vaccine series. Yesterday, I received my first shot in my left arm, and also another shot for taking hepatitis A in my right arm. I didn’t need “A”for school, but it was offered to me so I figured “why not?”. Today I spoke with the recruiter for school and she informed me that that taking those 2 vaccines together cancel each other out, and that I would now have to wait an entire year to start class because i would need a booster shot. I informed her that the shot was not the twinrec but two seperate, adult vaccines… Has anyone ever heard of this? Also, is it possible to take the 3rd shot in 5 months instead of 6?

    • Maybe I’m missing something, but that does not make any sense?? The travelers accelerated schedule for HBV is 0, 7 days and 21-30 days and then a booster shot at month 12. http://wwwnc.cdc.gov/travel/yellowbook/2012/chapter-3-infectious-diseases-related-to-travel/hepatitis-b.htm . Since you will dealing with blood, you would want to have an anti-HBs titre to be sure you have generated adequate immunity. Should you decide to do the 3rd shot at 5 months, definitely get your titres checked 1-2 months following the last shot to be sure you generated adequate immunity. I would think if you show you have generated adequate immunity, that would be enough to ensure you are good from the program.

  52. -Actually my sister was vaccinated her first dose on 4th December 2012.
    -Now he is pregnant for 3 months.
    -As per doctors advice, we check the HBsAg test, it shows positive.
    - Whether it is really positive or due to vaccination ?

    • The vaccine can sometimes result in a false-positive if tested within a month of the vaccine. However, since she is pregnant, I would look into this more carefully since there is always the possibility that she is actually HBV+ and not showing a false positive. Additional testing and reading of the results by a liver specialist will clear this up for her. If she is actually HBV+, she will want to prevent mother to baby transmission through prophylaxis which is very effective. Please encourage her to look into this situation more closely.

  53. Please clarify this for me. Why is it crucial to check hepatitis b titre before vaccination?

    • I’m not sure of your question. If you think you may have had a previous exposure, we would encourage you to be screened for HBV BEFORE vaccination. You can check the HBV anti-HBs titre 1-2 months AFTER the last shot of the series to confirm immunity, not before. However, some schools and jobs may require a titre test to confirm adequate immunity before being accepted into a program or position. This would be for people who had already completed the 3-shot series. If they find their titre has waned, they would need a booster followed by a titre test a 1-2 months after the booster to confirm immunity and permit them into the program.

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  55. I had titers drawn which showed no immunity. I just completed my third vaccine today for the series. I am scheduled to get new titers drawn in four weeks. The nurse informed me that if i am still not immune, i probably have hepatitis b and need an antigen level checked. Is this true because i am freaking out.

    • I don’t know when you were first vaccinated, or if this is your first vaccine series, or your second, but don’t panic. Wait to see how your anti-HBs titre test comes back in a month. If you do not generate adequate immunity, it wouldn’t hurt to have a hepatitis B panel run to see if you happen to be infected. Please know that there is a percentage of the population that are vaccine non-responders. This is true for all vaccines. If you are HBsAg negative, meaning you don’t have HBV, please be sure you have gone through two complete HBV vaccine series. Please note this blog, “Options for Vaccine Non-Responders” http://50.28.32.139/~hepb/?p=1229 that will give you some options that may help you generate immunity should you find your next titre is not adequate.

  56. This site is very useful :)

  57. My friend had donated blood last December and the bloodbank told him that he was Hepa B core antibody positive but Hepa B surface antigen negative. He only know that he had the symptoms of having hepa 12 years ago. His wife had a 2 vaccine dose prior to their marriage and he doesnt know if he will transmit it to his wife. He has also a 3 years old daughter to another woman, will it be possible that the child may have it. thank you

    • It sounds as though your friend had a previous HBV infection which he has resolved. This would mean that his hepatitis B panel shows that he is HBsAg neg, HBcAb pos and HBsAb pos. He is not infectious since he has resolved the infection, but since his wife has had two out the three shots of the HBV vaccine series, she may as well complete the series so she can be protected in case of future exposure. It does not matter if the time between shot 1 and 3 is well beyond 6 months. I think it would be a good idea to see if the mother of his child and his daughter were infected. Unless he can confirm an infection, and clearing of the infection 12 years ago, it would be best to just be sure neither of them are infected. There is much less chance of infection from father to baby than mother to baby, but if the mother was infected, you would want to confirm both were not HBV+.

  58. He has not yet been positive to HbsAb because it have not been tested with him. Now his wife has 3 doses of vaccine and is positive to HbsAb already. Are the wife safe now because they want to have a baby.

  59. I got the vaccine back in 1996 do I have to get it again?

    • Do you know if you generated adequate immunity after your vaccination? This would have entailed having your anti-HBs titre checked 1-2 months following the last shot of the vaccine series. You can have those titres checked at this time, but it is possible they have waned and not enough is circulating. That doesn’t mean you wouldn’t be protected, and that you wouldn’t generate an immune response if exposed, but there’s no way to prove it unless you knew your original results. So, you can have your anti-HBs titres checked and if they are below 10 IU/mL, you can get a booster shot and confirm immunity 1 month after the shot, or you can get a booster and check immunity. It’s up to you. The booster shot of the vaccine will not hurt you, but there is a good chance, but no way to prove if you have adequate protection.

  60. I got all Hep B shot , doctor office gave me one month one shot so I completed all 3 in 3 months. A week later they told me to get blood work done. I did, the result show I still negative. Doctor sent me to get another blood work( it about 3 weeks after I got the first blood work done). Later I found out I shouldn’t have HepB third shot on month 3. In fact I should have it on month six. In this case I would like to know is anything about this mistake from this treatment (HepB third shot wrong time) will cause me any health issue? Thank you

    • Getting the 3rd shot of vaccine series will not hurt you or cause a health issue. However, you did not generate adequate immunity as a result of the vaccination since you did not get the 3rd shot of the series at 6 months. Please be sure it has been 6 months since shot 1 of the series and get a booster shot. A month after the booster shot, ask your doctor to run an anti-HBs titre test so you can see if you generated adequate immunity. Most likely you will and you will be protected.

  61. Hello,
    I got the third shot in May 1998 at 20 months of age and was exposed to Hep b one month ago . Should i check for HBV ? Does the immunity last for such long time in patients vaccinated early in childhood?

    • Assuming that you generated adequate immunity following the 3-shot series completed at 20 months of age, you will be fine. However, most do not have their titre’s checked one month following the last shot of the series so they may not be sure they generated immunity. If you are concerned, ask your doctor to run a hepatitis B panel, just to be sure. Remember there is a 4-6 week window after exposure when you would not test positive even if you had been infected.

  62. ive had the vaccine and gotten all 3 shots now they want to do a titre to make sure the vaccine has worked, i work in the healthcare industry, i guess thats why they want to check. what are the possibilities the vaccine wont work?

    • It is not at all uncommon to do a titre test 1 month following the last shot of the vaccine series for those working in health care. Most likely you will be fine, though there is a small percentage of the population that are vaccine non-responders which means they failed to generate adequate immunity following 2 complete series of the HBV vaccine. Hopefully this won’t happen to you, but there’s a good blog with options for vaccine non-responders in case there is a problem: http://50.28.32.139/~hepb/?p=1229 Good luck!

  63. I have had my shot 1 and 2, but my parents did not give me the 3rd it has been 20 year since these 2 shots, can I just get my 3rd shot and be good after this time? And will the titer show if I am good?

    • The time in between shots in the series is the minimum amount of time between shots in the series. Get your 3rd and final shot and then get an anti-HBs titre run 1-2 months following the series if you want to confirm you immunity.

  64. I have a question, i am 24 male
    I have completed my hep b regimen when i was little, with booster shots growing up
    I took up nursing as my premed course and we are required to have hep b vaccine before our exposure in the community and hospital. I was 19 that time..
    I have only recieved 2dose of hep b vaccine and did not have the chance to take the 3rd dose. But im sure i have no exposure before getting the vaccine..

    I am now 24yrs old..i have recieved a hep b vaccine last 2012, and this coming month our school requiring us to take a hep b titer test..

    I had exposures like needle pricks, assisting a delivery with a hep b mom, and a few sex ( oral sex done to me, never for vaginal or anal sex), im perfectly fine

    Does it possible that i am have been infected for hep b?? I never had a hepatitis before neither their signs and symptoms of it? Its possible that i am a chronic carrier now??

    pls help badly need your help..im so depressed :(

    • I’m a little confused with your summary. It sounds like you were vaccinated to protect against HBV – perhaps more than once, and now you will be required to take an anti-HBs titre test? Were you vaccinated later in childhood where you could have been exposed prior to vaccination? Did you actually complete the entire series? Do you believe you have any particular risk factors such as a mom that is HBV+? If you know you have completed the HBV vaccine series and close family members do not suffer from chronic HBV, then I would try not to worry about it. Get the titre test and most likely it will be fine. If you do not show adequate titres, then get a booster and repeat the titre 1-2 months later. If you still do not generate adequate immunity then you should ask your doctor to run a hepatitis B panel. HBV is typically a silent disease and often has few or no symptoms. Please don’t let your worries depress you.

  65. Its been 4 yrs since i got another hep b vaccine and i dont know if my vaccines are enough to protect me with the infection full dose regimen in infant and 2dose only (not completed 3rd dose) and after 4yrs a hep b vaccine

    • I can only encourage you to have your anti-HBs titres tested, or if you believe you may have been exposed to HBV, then have a hepatitis B panel run to confirm one way or the other. If you received HBV vaccination at birth and you were not born to an HBV infected mom, then you are most likely fine and protected by the vaccine. There is a small percentage of the population that are non-responders to the vaccine, which it is why it is important to have your titres checked to confirm immunity if you are considering working in medicine.

  66. Thank u ive recieved my results anti hbs >500 mUI/l normal value: 15.0 mUI/l reactive

  67. I completed the 3 shots of hepa b but I lost my records.how can I prove that I dont need to be vaccinated anymore.tnx

    • Get an anti-HBs titre test run. If your anti-HBs titre is greater than 10 IU/mL then you have adequate immunity. This test is best run 1-2 months following the 3rd shot of the HBV vaccine series, which isn’t routinely run, so if you find your titre is below 10 IU/mL, then get a booster shot and repeat the titre test 1-2 months following.

  68. I have done my shots on an accelerated schedule. Shot 1 3/8, Shot 2- one month later, and am scheduled for my shot 3 on 7/5. I need to be able to do the titre and have quantative immunity no later than 7/29. My Dr. says I can go ahead and get my 3rd shot a little early and do the 30 days later so I can make my deadline. Do you think there will be a problem doing the 3rd shot 10 days early? Or staying on schedule and doing the titre 24 days after the 3rd shot? I have to have all this done in order to apply to RN program and nothing can be pending. What are my chances that the result will show quantative immunity?

    • The amount of time between injections is the minimum amount of time which should enable the person to generate adequate HBV immunity. However, keep in mind that everyone’s immune system is unique. I don’t have any study data to note how any timing changes may affect the probability you will generate adequate immunity. There is a small percentage of the population that are non-responders in general, but most likely you will not fall into that category. Personally I’d probably stay on the schedule and take the titre a few days early. You can always repeat the titre. You might well generate a titre if you get the shot early, but you do want to be sure you generate longterm immunity. On the much accelerated travel schedule, the person gets a 4th additional shot at 12 months.

  69. very worried:(

    Hi, I need to show a paper in a 2-3months that I have been vaccinated, but I just found out that I have only got 2 shots.. It was done approximately 5year ago. I am going to the clinic to sort this out but I also wanted to ask here. Is it possible to get the booster shot now? If possible, what is the possibility of getting enough titer after it? Thanx in advance.

    • Yes. The time in between shots is the minimum amount of time between injections. Get your 3rd and last booster shot now and have your titres tested 1-2 months afterward to confirm you have generated adequate immunity.

  70. very worried:(

    Hello again,
    I found out that I had completed the 3shots 16years ago and had a booster in 2003.
    Then I got 2shots 5year ago…

    • Honestly you should be fine since you have nearly completed 2 series of the vaccine, but if you have not had your titres tested, you will want to do that to be sure you generated adequate immunity. If it is below 10 Iu/mL then get the booster and repeat titre 1-2 months later.

  71. very worried:(

    Thank you for your responces. I will receive the results in a week or 2.
    I hope I have enough titer.

  72. How is the effectivity of hepaB vaccine?i just had my hepaB vaccine last june4,i had needle-pricked last may11 of this year with hepaB patient..i’m so worried pls help me..i had first or second dose before and i can’t even remember what year i received..how is that?

    • It is an effective vaccine, though it sounds as though you did not complete all 3 shots of the series. I am not sure based on your comment. It sounds like you may have only had 2 out of the 3? If that is the case, then you may not be adequately protected. Please be sure to have your doctor run a hepatitis B panel so you can determine whether or not you have HBV. This is very important. If you find you do not have HBV, please be sure to complete the vaccination series so you can be sure you are protected. If you are working in health care, I would recommend that you get an anti-HBs titre drawn 1-2 months following the last shot of the series. If it is above 10 IU/mL, then you have adequate immunity and should be protected for life.

  73. Hi, hepbtalk! i’m just curious about the timing of 1st dose HPV vaccine recommended by Centers for Disease Control (CDC), which should be injected probably around 12 hours after birth. Is there any significant findings about this timing? And why CDC choose to recommend vaccination as early at this age (around 12 hrs afterbirth)? tq :)

    • Because babies and young children are most susceptible to hepatitis B. If a baby or young child is infected with hepatitis B they have a 50-90% chance of remaining chronically infected. It’s a precaution that keeps all babies HBV free. I am not sure about the 12 hours. It’s all based on study data.

  74. I would like to ask if two live vaccines were given less than 4 weeks, say first dose was mmr followed by chicken pox. Which is the failure vaccine? How will you give now their booster doses? Thanks

    • It is not at all uncommon for multiple vaccines to be given at the same time. I don’t think I understand your question, or if it relates to your HBV vaccine?

  75. Hi,I’m so worried please help me ! I was vaccinated for hepatit b in 2010 ,vacine was not respondet so I get anouther cours of vacination .I went to check if I got immunity for the vacine and after that they sad to me that they need to make anouther blood test becouse is posible to hepatit b positive.!!!please help me what do you think way they need anouther test to confirm .?.. Thanks a lot

    • I believe I addressed this. Sorry for any redundancy. If a person does not generate immunity after 2 complete vaccine series, then they are considered a non responder and would be tested to be sure they do not actually have HBV and that is why they are unable to generate immunity. This is standard procedure, so please do not panic. If you find you do not have HBV, you can look at some of the recommendations from the blog: “Options for vaccine non-responders http://50.28.32.139/~hepb/?p=1229 in order to try to generate immunity.

  76. I had my 1st shot and then my 2nd shot but its been 7 months for the 3rd shot does that pose a problem? I am in the nursing program and it is required but I was suppose to get the 3rd shot 6months from the 2nd.
    I am concerned that I will have to start the series of shots over and if thats the case I want to start now before September and the school tells me I can not start.

    Thanks

    • The time in between injections is the minimum amount of time according to schedule. Please get your 3rd shot to finish up the series. It will not be a problem. If you are vaccinated on the accelerated schedule, please be sure you have your anti-HBs titres checked one month following 3rd and last injection to confirm immunity. Many nursing schools require this titre check so keep your lab records.

  77. what happen if i have hepatite 2 and then i get vaccine?

    • For those already infected with HBV, the vaccine will not change their HBV status. They will not respond like those who do not have HBV.

  78. If i had hepatite b and then i get vaccine, what happen?

  79. I know if I have hepatite B, the vaccine will do me no good. I want to know why?

    • Yes. it is true that the HBV vaccine will not help those already infected with hepatitis B. You already have large amounts of HBsAg circulating in your blood and your body is not able to generate an immune response. Getting a vaccine will not help that response.

  80. My 18 year old son is scheduled at his doctor’s office to receive all 3 Hepatitis vaccines at once. Is this safe? Is this effective?

    • That does not make any sense. Perhaps he is having an HBV injection and also getting other injections at the same time? The vaccine is administered at 0, 1 month and 6 months. This is the minimum amount of time in between injections in the series. Please talk to your son’s doctor’s office. He will not generate immunity to HBV if he receives all 3 injections at the same time!

  81. Hello, I have had the Hep B vaccine 6 times in the past 10 years due to not keeping good records. Is this harmful to me in any way? Thank you!

    • No, it is not harmful to repeat the series, but there is certainly no reason to repeat at that level. Get an anti-HBs titre and see if you have adequate titres. if you do have adequate immunity then studies show you don’t need to repeat the series or get a booster

  82. Hi hepbtalk, can you help me with my case.. I was vaccinated as infant, full 3 doses, and i received boosters till 2005. Lately i pricked myself with a lancet needle of a patient of unknown status… ( I work in a pharmacy where we do regular glucose monitoring tests).. I have never done anti-HBs titers, but again i had my fair share of boosters… What are my risks of getting infected… Thank you

    • Your risks are low, but for peace of mind, I would consider having your titres run. Despite boosters, it’s possible your titres will be below, though you’re likely protected due to immune memory, but we just can’t prove it. So consider getting a booster and have the titres checked 1-2 months after the booster. if your titres are adequate then you don’t need to worry about any exposure or getting further boosters.

  83. Scenario: Hepatitis B Series completed, titre negative. Received 2 booster shots – and repeat titre negative. Recommendations??? Should full hep B Vaccine series be received again? How many times can you receive the full Hep B Vaccine series – if you continue to not develop the level of immunity needed for protection? Thanks!

    • A person is not considered an HBV vaccine non-responder until he has gone through 2 complete vaccine series. It will not hurt you if you get more than one series of the vaccine. Please read HBF’s suggestions for vaccine non-responders at http://50.28.32.139/~hepb/?p=1229 print it out and discuss with your doctor. You may benefit from vaccination with a higher concentration of the vaccine.

  84. Thank you for your response and one final question. To your knowledge has there been any cases of people who got infected with hepatitis B although they were vaccinated… In other words people who didn’t know that they were unresponsive to the vaccine and managed to get infected… Thank you…

    • I don’t have study data, but certainly if a person did not generate immunity to HBV with the vaccine, they may certainly get HBV if they are exposed. The other scenario that can occur is when someone is vaccinated to protect against HBV, but they may already have an infection. When this occurs the vaccine is not effective and the person may assume they are protected when they are not.

  85. hi hep b..i have gf who have hepa b positive,,i have sex with her..after 3 weeks i go to clinic to test if i have been infected and the result is negative then i got shot then followed after next month then follow again before 6 month of the first shot..my question is if i am infected even the result is negative after 3 weeks when i have slept with her??

    • There is a 4-6 week window where you would not test positive even if you had been infected due to your exposure. That means I cannot tell you if you have hepatitis B as a result of your exposures as a result of unprotected sex. I would encourage you to practice safe sex until you clear the 4-6 week window. Then you should be re-tested. If you do not have HBV, then be sure to continue with the 3-shot series to protect you from getting HBV from your gf, or others means of transmission.

  86. hi hepbtalk i amso worried if im infected because my gf have hepa b,,then i slept with her then after 3 weeks i check if i am infected the result is negative then i got shot on that day then follow after 1st month then the 3rd shot after 6 months..did i infected even if i have the 3 shot??plss i need your answer plss help me im so worried now

    • Okay, so it looks like you completed the 3-shot HBV vaccine series, which is good. The only way you will know for sure whether or not you contracted HBV before you received the vaccine is to get tested. Ask your doctor to run a hepatitis B panel. You might also consider getting a titre test (should be done 1-2 months following the 3rd shot of the series) to ensure that you generated adequate immunity as a result of your vaccine. Then you won’t need to worry about HBV again.

  87. is it possible that i am infected even if i have completed the 3shot?what do you mean of 4-6 weeks window?

  88. Hi, I got my Hep B vaccine (3 doses) when I was younger.
    I am going to med school this year and I went to get blood work to prove I was immune.
    The results came back negative and said I wasn’t immune (<10).
    So now, I am getting the whole series done again. How does this happen and why?
    It's sort of stressful too because I need the vaccines in order to start med school.

    John

    • THe titres may wane over time, but that does not mean you wouldn’t generate and immune response if you were exposed. The problem is there is no way to confirm you generated immunity when you were first vaccinated. You don’t need to repeat the entire series. Get a booster shot and 1-2 months following the booster shot, have your anti-HBs titres checked to be sure they are greater than 10 IU/mL. That should do it, but if not, then you can complete the series and then do the titre a month after the last shot of the series.

  89. I had my 2nd hepatitis b vaccine yesterday and I need to get my 3rd one before August because I’m going on my internship on October. If I don’t get it I will go on january, do I really have to wait 5 months to get it, Or can I go to another doctor.

    • The time between shots in the series is the minimum amount of time between injections. You may not generate adequate immunity if you do not wait an adequate amount of time! You can consider the accelerated schedule for travel which is a 4 shot series, which is given at 0, 7 days, 21 days and month 12. The booster shot at 12 months provides long-term protection. If you will be performing any at-risk activities, you may wish to consider an anti-HBs titre 1-2 months following the last shot of your series to be sure you generated adequate immunity.

  90. im supposed to have my second shot last June 20 but i missed it.. I got it though last July 19, 2013. Does the vaccine still have an effect on me? When should i get my third shot considering that my second shot was moved?
    Thank you.

    • The time noted on the vaccine schedule is the minimum amount of time in between shots. There is not a problem with you getting the 2nd shot of the series a month “late”. Get your 3rd shot of the series 6 months after the first shot of the series. The goal it to be fully protected a soon as possible, but if you are a little late in between shots, then it will not affect generating immunity.

  91. hi hepbtalk..what is if im not check my titre before 2 months?what will happen?

  92. Hi..my baby had had his 3-series hep b vaccine with a diff doc. But when i took him to his reg ped, his ped said the shot # 3 was injected too early so he said to do it again. Is it necessary? The shot # 3 was injected when he was 5 months, not even 6 months old yet. So do u think he has to repeat the #3 shot again? He’s 7 months now. Thanks

    • The time in between shots in the series is the minimum amount of time. You really don’t want to get the injections early. You can either do a blood test to check the anti-HsAb titre of your child and if it is adequate skip the 3rd shot, or you can just repeat the 3rd shot. It will not hurt your baby to repeat the 3rd shot, but it’s up to you if you would prefer to test the titre first.

  93. I got my hepa b vaccine last april and i didnt took the 2nd and 3rd shot since now. What should i do? Should i took 2nd and 3rd shot or repeat the whole thing? or should i took a hbsag titer because according to my mom i took my vaccine and booster when i am young, i am worried and confused what to do after i took my first shot last April.

    • Sounds like you have had only the first shot. You do not need to repeat the first shot, but continue with the 2nd shot, and then the 3rd. If you want to confirm your immunity to ensure you are protected against HBV, then you can have your anti-HBs titres checked 1-2 months following the 3rd shot of the series.

  94. I work in a hosp setting i got my vaccine 6 yrs ago i have checked my titer 5 mos ago and it was 66.97 IU/L but because of my exposure in my work i started my full series of vaccination again i have finished the 2 doses and now waiting till october to get my last. Is this ok? Am i totally safe if i will b exposed to hep b?

    • Your anti-HBs titres are fine. You did not need to repeat the vaccination series. There is no reason for you to complete the 2nd series, though it will not harm you. It’s just not necessary. An anti-HBs titre of 66.97 IU/mL is more than enough to protect you should be exposed to HBV at work. However, continue to practice standard precautions so you do not risk contracting other blood borne pathogens such as HIV/AIDS and Hepatitis C.

  95. I’m supposed to have my third shot on August 5,but they canceled my appt. and schedule it for September 10.From the first(February 2) and third shot it will be in 7 months.Is it to late or not?

    • That is fine. The time on the schedule in between shots in the series is the minimum amount of time, so if you need to extend the time, that is fine.

  96. hi I got my hep b vaccine when i was 1 year old. I’m 22 years old now and i went to do blood work done for school and they told me that i wasn’t immune to hep b. that i never took the 3 shots because my lab came back non- immune. How is that possible?

    • Sometimes the titres will wane over time. This doesn’ t mean that you are not or have not been protected, but unless you had your titres checked after the initial vaccine series, there is no way to confirm immunity for your school. Get a booster shot of the HBV vaccine and have your titres checked 1-2 months later. If your titres are greater than 10 IU/mL then you have generated adequate immunity and you’re protected. You will not need to repeat boosters or titres for 20 + years which is the length of current, ongoing studies, or if you learn of an immune system dis order.

  97. I get my 1st booster and wait a month for my 2nd booster. How much likely can I have the “reactive result” in my blood test after a month getting the second booster?

    • I am confused. Is this the first time you are being vaccinated or are you getting a booster shot? The HBV vaccine series is a 3 shot series, so you need to complete all shots in the series to confer longtime immunity. The first shot gives you UP TO 5-% protection and the 2nd gives you UP TO 80% protection, but will not provide extended immunity. If you wish to confirm immunity you can have your anti-HBs titres checked 1-2 months following the last shot of the HBV vaccine series.

  98. Christian Sullivan

    Hello. I’m having a little trouble trying to figure out how to go about my vaccines. I got my first hep b vaccine last february (twinrix) and completely forgot to return for the rest. I got my 2nd dose of twinrix in may. Do i have to start the whole thing all over again, or can I just get the hep b vaccine and still be immunized??

    • The time in between injections of the series is the minimum amount of time, so you do NOT need to restart the series. Why don’t you just get the last shot of twinrix? You want to wait at least 5 months between shot 2 and shot 3 for twinrix so get it in October.

  99. What happens if I do the 1st shot then I do the 2nd one and then I want to have another baby and fall preganant, I know I can’t put vaccination so is it ok to wait after baby is born to do the 3rd shot?
    Thank you

  100. What happens if I do the 1st shot then I do the 2nd one and then I want to have another baby and fall preganant, I know I can’t put vaccination so is it ok to wait after baby is born to do the 3rd shot?
    Thank you

    • It is safe for you to get the third and final shot of the series while you are pregnant, but if you decide to wait, that is okay too. the amount of time in between shots of the series is the minimum amount of time. So yes, you can wait until after the baby is born if you would prefer. Best of luck!

  101. Please help me
    My hisband and i would like to have a baby. He has hbv.
    I have just finished my 3 shots. Is it already safe to concieve?
    And when would be the best time is it weeks or months or could it be
    Days after i jave completed my vaccine to try to have a baby.
    Please help me.

    • Glad to hear you completed all 3 shots of the series. Why don’t you check to confirm your immunity with an anti- HBs titre test? Wait one month from the time of your shot of the vaccine series and ask your doctor to run an anti-HBs titre test. This is a test that returns a number. If the result is greater than 10 IU/mL then you are protected from HBV, and your baby will be too. Just be sure to have baby receive the first shot of the HBV vaccine series before he or she leaves the hospital and follow up according to schedule for the other 2 shots in the series.

  102. I have been tested postive for hbv, the doctorl told me that I recovered I was Immune.
    I was negative for hbsag, however He said me I didn’t produce suffient antibodies and recommended me to take the complete series of vaccination! I took the first two shots, my anti-hbs is currently 10 and negative for hbsag
    I just want to know If I am immune and completely recovered!

    • That’s good you were able to generate immunity due to vaccination. You are recovered and immune, but in the future be sure to remind your doctor or future specialists of your resolved HBV infection. This is particularly important in the event that you require longterm use with immune suppressing medications.

  103. Hi!Please help me
    I am a volunteer in a hospital and six days (8/22/2013) ago i accidentally touched blood from a hepb patient.I didn’t have scars or cuts on my hand but the skin on my fingers had small abrasions.That exactly moment i didn’t realised because he admited he has hepb two hours later.Today (8/27/2013) I have been to the doctor and he took me a blood sample and I got my first vaccine shot (engerix b).The doctor told me the vaccine is stil appropriate because the viral replication takes 40 days.I cannot sleep at night thinking I might have hep b .Is anything else I can do ?I am 22 years old and I don’t want to have my life screwed up because of this.Excuse my English but it’s not my native language.

    • HBV is transmitted through direct contact with infected blood – literally blood to blood (his blood to open abrasions on your hand) . It was good that you were vaccinated after the exposure to a patient with hep B. Please complete the vaccine series to protect against future exposures. Be sure you are screened for hepatitis B 4-6 weeks after the exposure to be sure you were not infected. Ask your doctor to run a hepatitis B panel that checks for HBsAg, HBcAb and HBsAb. While you wait take care with sexual partners by practicing safe sex and do not share personal items such as razors, toothbrushes, nail clippers, body jewelry or items that may have very small amounts of blood on them. Hopefully you will learn you were not infected and you will complete the series and be protected.

  104. Helllo

    am 29yrs old guy.i recently have acute hep b with jaundice. at that time my Sgpt is 2800 in june 1st week, now my sgpt is 66 and my Hbsag value is 0.16 and cut of value is 0.10,so now also it is positive.How much time to take my HBsAg become negative. Dr told that it was acute.so no need of worry. and my anit-Hbc Igm is positive in july 1st week, .last two months dr give me the lamividine tablet. is there any side effect for taking this tablet for acute hep.
    My partner take 2 dose of vaccines.is she safe at this time?
    but i have many doubts on this.
    after recovering from this can i pass the medical exam on gcc countries if i had acute hep b pastly.? Can acute hep b come again if it is previously cured??
    Can i take hep b vacine after recovering from acute hep B. After recovering from this also is their any chance to spread heb b to my partner?
    pls help me in detail. Thankyou in Advacne…

    • It may take as long as 6 months (though certainly may be less) to clear an acute hepatitis B infection. When you resolve an acute HBV infection, your HBsAg will become negative, HBcAb will remain positive and your HBsAb will be positive. If an HBV DNA viral load is run, it will be undetectable. 90% of healthy adults with an acute infection will resolve the infection on their own. Once the infection is resolved and they develop immunity, they cannot get HBV again and they will no longer transmit the virus to others. Most employment screening tests screen only for HBsAg, so once you have cleared the virus, you are good. With the 2nd shot of the series, your partner has up to 80% immunity. It’s best to continue practicing safe sex until you have resolved your infection. There is no reason to get the hepatitis B vaccine. Those that have or have had HBV do not need the HBV vaccine. Be sure to confirm that you have resolved your HBV infection. In the future, you need only tell the doctor about your resolved acute infection if you are in need of long term immunosuppressive drugs in the future for conditions such as rheumatoid arthritis, psoriasis, cancer etc. Otherwise, you are good.

  105. I am a Registered Nurse and completed my course of hep b vaccinations in 2010. The blood test to test immunity was > 222 mIU/mL several months after completing the 3 courses of vaccination. This indicated I was immuned (which is a requirement to work for the health service i am in). So it turns out I have been working in health care since thinking I was immuned to hep b, however I recently had routine bloods as I am pregnant and the results indicated I am not immuned to hep b with level of < 10 mIU/mL. How is it possible to be immuned then 2 years later not be? It is a scary prospect to think there are others out there that think they are immuned but are not. I would have never known if I didn't get pregnant. How common is this?

    • it’s not unusual. Since you had your titres checked following the last shot of your vaccine series you are protected. The titre level may drop below the acceptable range with time. Immune memory would protect you in the event of an HBV exposure where you would once again generate surface antibody. The levels may not be high enough to trigger the test, but your immune system will launch an attack if exposed. Often people do not check their immunity 1-2 months following the HBV vaccine series, so they never no if they ever generated immunity. That being the case, since immunity was not confirmed, a booster shot would be recommended since there would be no way to confirm one way or another if they had ever generated immunity. On going studies show those that have generated immunity will be protected 20- 25 years, or the length of these ongoing studies.

  106. Hi Hepbtalk,

    I took my second hep b shot only 3 weeks after the first shot (due to some confusion with my general physician and OBGYN, and my forgetfulness). Are there any risks from that?

    • The minimum amount of time between shot 1 and shot 2 of the series. The risk is that you may not generate adequate immunity. At the end of the 3 shot series, I would recommend that you ask your doctor to run an anti-HBs titer test 1-2 months following the last shot of the series to ensure that you have generated adequate immunity. If you did, then you are all set. If you did not, then you will need to get a booster shot.

  107. the 1st two shots I had were on my butt nd I hear it’s not given on d butt. Is that valid. Though the third one was on my shoulder and it was 4 years after the 2nd.

    • it’s true that studies show that injections given in the buttocks may not be as effective. It’s up to you. You can have your anti-HBs titres checked to confirm immunity, or you can get 2 HBV vaccine injections in the arm and repeat the anti-HBs titre 1-2 months following the last injection of the series. The time in the schedule is the minimum amount of time between injections. It is okay if the time in between shots in the series is longer. The 3rd shot of the series should be separated from the 2nd shot of the series by at least 8 weeks.

  108. HI. I was glad to read that it is okay to receive the third shot up to two years later then the 1 and 2 and been completed as scheduled. My question is that I had the first and second shots completed in 2009 and I just made my appointment to resume with the 3 shot. I was wondering if 4 years is too long between them seeings how your article only mentioned two years. Thank you for your response so that I can decide to restart entire series at my appointment next week or just continue on the 3 shot!!

    • Yes to can get the 3rd and final shot of the series and do not need to restart the series. The time in between shots in the series is the minimum amount of time. Naturally the goal is for a person to get full protection from HBV as soon as possible, but you are okay to make your appt. and get your 3rd and final shot of the series.

  109. I am infected and i had hepb vaccine.what will be the side effect of having it although i am already infected?

    • The HBV vaccine should not hurt you though there will be no benefit to receiving the vaccine if you already have HBV. There should be no side effects as a result.

  110. I received the 3 immunizations about 15 years ago. I just had my titre done and I no longer have immunity. Do I need a booster shot or do I have to start the schedule for 3 shots again? Thanks!

    • Unless you had a titre test run 15 years ago, and you know at that time that you generated adequate immunity, you will need to get a booster shot. 1-2 months following the booster, you can then repeat the anti-HBs titre test to confirm immunity. If you know you generated adequate immunity 15 years ago, then you do not need a booster.

  111. Well, my 1st shot was on Aug. 10, today (Sept. 10) is supposed to be my 2nd shot but I don’t have enough money yet to pay for the vaccination. So, is it okay that I take it tomorrow (Sept. 11, 2013)? Will there be side effects if I take my 2nd shot tomorrow? How will this affect my schedule?

    • Yes. It is okay if you need to delay your 2nd shot. The time in between shots is the minimum amount of time needed. If you need to extend it, that is okay. Of course the goal is always to get vaccinated so you can be protected. However, if you can’t afford it, you can wait.

  112. I received the 3 vaccines many years ago but i don’t remember when was it taken. I am not sure if there is still protection in my body, so i go to repeat the the 3 vaccines. By right should i repeat the 3 vaccines again or booster dose? will it prolong the protection after i repeat the 3 vaccines or it is just a waste and ineffective at all?

    • You can ask your doctor to run an anti-HBs titer test. If the results are greater than 10 IU/mL, then you are protected. Since it has been a number of years and you do not know for sure if you generated adequate immunity at the time of the original vaccination series, it is possible your titre will be below 10 IU/mL. So if your results are 10 IU/mL or greater, do nothing because you are protected. If your titers are less than 10 IU/mL or not detectable, then get the booster shot. If you wish to confirm immunity, you can re-run the the titer test 1-2 months following the booster.

  113. Lets say my titre is less than 10 IU/ML. But i repeat the 3 vaccines instead of booster, so is it effective and will it protect me? What is the advantage if i repeat the 3 vaccines instead of booster?

    • Getting the additional shots will not hurt you, but the booster should be sufficient. There is a percentage of the population that does not respond to the HBV vaccine or even other vaccines. Without running the anti-HBs titre test a month after the booster or 3rd shot of the series, you will not know for sure. However, most likely the vaccine will be effective and protect you.

  114. am married a month ago. and got tested to have the virus. both have been dating since a year. she got teated: negative. what are the chances of having children

    • Good to hear your wife does not have HBV. Please be sure your she is vaccinated to protect her from getting HBV. You may be in an inactive phase of the virus at this time, but that can change. Be sure she gets vaccinated. Having HBV should not impact you having children. When your children are born, please be sure they are vaccinated. CDC recommends that babies receive the first shot of vaccine before they leave the hospital. Please be sure you see a liver specialist to can learn more about your HBV and your liver health.

  115. i got my first shot and second shot in 2008. do i need to restart my series? or is it ok to just get the third?

  116. can HBV transmitted through saliva???

    • The HBV virus is present in blood and body fluids – including saliva. However, the concentration of HBV in saliva is much less than it would be in blood. There is also the added complication of the possibility of trace amounts of blood in saliva. So the risk may be less with saliva, but there is a risk of transmission.

  117. I took my 1st and 2nd shot already but I extended the time for the second shot for one month do I have to start all over again?

  118. I had to taken the series shot years ago and found out I have the vaccine but forgot I got it done. I just got the first shot is this harmful to my body? And should I continue the shots?

    • Getting a booster shot or even repeating the series will not hurt you. If you like, you can choose to confirm your immunity following this recent booster shot 1-2 months after by getting an anti-HBs titre test. If the titre is above 10 IU/mL then you are protected for at least 25 years or the length of ongoing studies.

  119. Hi,
    I have a ANTI-HBs REACTIVE what does it means? Can I have a hepa B BOOSTER if I am ANTI-HBs REACTIVE?

    Thanks,

    Lorena

    • if you are anti-HBs reactive, then you already have generated immunity to hepatitis B. You should not need a booster shot, since you are already immune, though if you had gotten one, it would not hurt you.

  120. helow sir iam from pakistan and mine freind whose hbs is positive but his blood with small quantity is fall on my thumb and i have no injury in my thumb i just washed my thumb with detergen and when i was child i do vaccine of hbs is iam at risk of getting hbs iam in tension now and 21 years old and after that i do vaccine after 24 hours my ist dose on 14th of this month will i take my next dose now bevz i read tht u can quick take ur protection by 0,07,21 days help me sir thxxxxxx

    • Transmission occurs through direct contact with infected blood – literally blood to blood. If you did not have any tiny cuts and you washed your hands, it is unlikley it would have been transmitted. However it is good that you have been vaccinated to protect you against hepatitis B both previously and now and moving forward. It sounds as though you may have gotten a booster as a result of this exposure, which is fine. If you know you completed the series as a child then I would encourage you to get an anti-HBs titre test run 1-2 months following the booster shot to confirm your immunity. If the titre is greater than 10 IU/mL then you are protected for life – or at least 25 years which is the time of on-going studies confirming immunity. Assuming your immunity is good, you do not need to repeat the entire series. The series you mentioned is an accelerated series and would require an additional HBV injection at 12 months.

  121. and after one week i take my blood test which is negative. should i take my vaccine now with 2nd dose thankyou

    • Not sure if part of this question is missing? If you have been screened for HBV and it is negative, then yes, you should get shot 1 of the vaccine series followed 1 month later by shot 2 and the 3rd shot 6 months from shot 1 or at least 4 months from shot 2.

  122. My son was born in Jan. 2011 and he got his first Hep. b shot at birth, the second at one month and the third at four months,, so the interval between the second and third shots was less than 4months. I’ve just realized that ,as I was comparing between his vaccination schedule and his brothers’ ones. So Is there any harm for my son’s health?

    • THere is no harm to have the injection earlier, but your son may not generate adequate immunity. The time noted in between injections is the minimum amount of time between shots in the series. You may wish to confirm immunity by running an anti-HBs titre test. It if is 10 IU/mL or greater than he generated adequate immunity. If less than 10 IU/mL then he will need a booster shot.

  123. I got my 1st shot around 27th March, 2nd shot around 27th April and 3rd shot 6th of September. Was my third shot too early? I’m having a blood test to check my levels in November, if they are above 10 IU/mL does this mean its worked and doesn’t matter if my 3rd one was a bit early?

    • You are correct. Yes, you did get your shot a bit early, but if you get your titres back and they are above 10IU/mL then you are all set and would be immune. If not, get a booster and repeat the titre test – if you wish, 1 month from the booster.

  124. I was exposed to saliva of hbv person as i had french kissed the girl. I got the 1st dose of vaccine on 3rd day of this exposure. After the 2nd dose , there was another kiss. Now its been 160 days since the 1st expsosure. Should i be worried for hbv? there have been no symptoms as such. Plz reply as i have lot of anxiety.

    • The concentration of the virus is lower in saliva than blood or sexual fluids, but of course a risk still remains. If you are truly worried, then I would ask your doctor to screen you for HBV (hepatitis B panel or HBsAg test) There is a 4-6 week window, so you might want to wait another couple of weeks and get tested. It’s up to you. If you will continue to have a known exposure to HBV through blood or other body fluids, then you may wish to have your titres checked 1-2 months following the 3rd shot of the series. If your titre is greater than 10 IU/mL, then you are protected and do not need to worry about getting HBV from your partner

  125. Pls I got my 1st and 2nd shot of the vaccine in 2007 and i never went back for the third shot. I just found my sister has the virus as she got tasted a month ago.. am at risk.. do i need to do the test again or sold I just get the third shot… can the first and second shot protect you

    • I dont know your history, but it is possible that your sister has had HBV for many years – unless you know for sure it is an acute infection. If you do not know, then I would ask your doctor to screen you for hepatitis B to be sure you do not have the virus. If you do not test positive, then you can get the final shot of the series. If you wish to confirm your immunity, then you can have your anti-HBs titres checked 1-2 months following the last shot of the series. The time in between shots is the minimum amount of time, so your first 2 shots are good and would have provided up to 80% coverage. Please remember that HBV is not casually transmitted, though household members are more susceptible since they may accidentally share personal items that may have trace amounts of blood on them (razors, toothbrushes, clippers, etc.)

  126. Sir iits really good that u reply our question answer very quick sir I want to known that I want quick protection becz I am exposure from hepatites b blood so I get vaccination after 48 hours and second dose after one week and now I will get 3rd dose so is iam safe now from hbsag I am in tens now

    • So you are on the accelerated schedule for the HBV vaccine which is 0, 7, 21 AND a booster shot at 12 months. Please do not forget to get the booster shot. I would still encourage you to be tested for HBV 4-6 weeks after the exposure to confirm you are not infected, though your protocol should help. It is preferable to get the first shot of the vaccine within 48 hours and a shot of HBIG, which is not available everyone. Once again, please confirm your status with testing at 4-6 weeks.

  127. Please help. I had an exposure of saliva from an hbv +ve girl through kissing. Within 3 days i got the vaccine 1st shot for prevention. Then after 2nd dose we had kissed again and again exposure to saliva. Now I am a bit scared that I might not get jaundice for acute hepatitis b if exposed. Does the vaccine work as post exposure in this case? its been 160 + days since the 1st exposure and around 100+ days since the 2nd one. My 3rd dose is due in October. Do all get jaundice etc from acute hepatitis. I am worried. Please help.

    • Quite often there are no symptoms associated with an acute infection, so it is true you may not know if you were infected. however, the concentration of HBV in saliva is much lower than in blood or sexual fluids. There is immunity generated with each shot in the series – up to 50% with the first shot and up to 80% with the 2nd shot. The third shot completes the series providing coverage and durability.

  128. Can one be infected with hep b 3 weeks after the first shot?

    • Yes. It’s possible since you have not yet generated adequate immunity. A person will generate up to 50% immunity with the first shot of the series and up to 80% after the 2nd shot of the series. Be sure to finish all shots of the series for complete converge. If you believe you have had an exposure to HBV, then you can get tested 4-6 weeks following the exposure to be sure you have not been infected

  129. I got the second shot 7 1/2 months after the first.

    If I don’t have to start the series over, then how long should I wait to get the third and final vaccine after the second? You said 4 months in one of the responses above, but that was to someone who was only delaying their second shot by a month, not by 6 1/2 months, so the total number of months between the 1st and 3rd shot for that person still equals a minimum of six months. I am well past the six month mark already.

    The facility I went to get the second vaccine said five months after the second, but they are going on that schedule of 0, 1 month, and 6 months as stated above, and they pushed me out the door before I could mention the time gap between the second and first shot. And yet, by the time I got the second shot I was already past that 6 month minimum suggested to get the third, technically.

    I am trying to get into a nursing program and would like to finish the series of shots by the Spring 2014, if I can help it. I just got the second shot on 9/26/13, and the first was 2/14/13. If I can get it this Fall or Winter, I’m perfectly happy with following up with a titer to verify immunity.

    • You need to have a minimum of 4 weeks between shot 1 and shot 2, and a minimum of 8 weeks between shot 2 and shot 3 AND a minimum of 4 months between shot 1 and shot 3. Verify immunity 1 month following the final shot of the series with an anti-HBs titer

  130. My mom just found out she has hepatitis, and was told not to share cups or anything and before that i have been drinking from her cup and everything. I have the 3 hepatitis shots can i still get hepatitis?

    • HBV is not transmitted casually. HBV is present in body fluids, but the highest concentration is in infected blood. Be sure to avoid direct contact with infected blood. You should be protected if you have been vaccinated, but if you wish to confirm you immunity, you can ask your doctor to run an anti-HBs test. If your titer is greater than 10 IU/mL then you are protected. If the titers have waned, you can get a booster shot and repeat the titer test 1-2 months following the booster.

  131. What is the difference between the shots used in the hepatitis b vaccine series and the booster shot?

    Also, what is the difference between the first, second, and third shot in the series? Are they all the exact same thing, so you are getting the exact same injection 3 times to complete the series, or do they have different strains or concentrations of the vaccine?

    • There is no difference between shots in the series and a “booster dose”. However, there is the option for different concentrations of the vaccine that may be given to those receiving hemodialysis or with compromised immune systems. This higher concentration may also used for those that are apparent vaccine non-responders. There are also different concentrations of the vaccine made by the different manufacturers.

  132. Hi,
    I had a possible hep b exposure when a condom broke and when to a local hospital for testing. I was negative for hep and have no immunity, I was given my first shot of the vaccine approximately 12 hrs after the possible exposure from vaginal fluids.
    I was advised to have the second shot at 4 weeks and the last in another 4 months time.
    Would an accelerated vaccination process of 0, 7 days and 21 days help prevent an infection? No HBIG was available at the time but would it still be viable a week after exposure. Thanks

    • It is good that you received the first shot of the vaccine series within 12 hours. I would continue with the regular series. You do not need the accelerated series which would also require a booster shot at 12 months in order for you to generate a durable response. So go with shot 1, followed a month later by shot 2, and follow up with shot 3, 6 months after shot 1 and 4 months after shot 2.

  133. HI! Thank you for you educational answers. I just got my first shot today my second shot is scheduled on the December 1st. but just about 3 weeks after that 2nd shot, I’m travelling to a very risky area of Africa for a month for some social work. will I be protected by the 2 shots? what precautions should I take? thank you!!!!

    • 2 shots of the HBV vaccine series will provide up to 80% immunity. You could also consider an accelerated vaccine schedule. It involves and extra shot, but you will actually get 3 shots of the series in before you leave. The schedule is: DAY 0, DAY 7, DAY 21 and a booster dose at MONTH 12 . This is a very good option.

  134. I had my anti HBs titer check a year ago it was 65 iu/l because i had my vaccine when i was studying in nursing school.i recently got married and my wife and i just found out that she is HBsAg positive is there a chance that i will get infected or should i get another set of vaccine?thanks!!!

    • Since you had your titers checked and you know you generated adequate immunity, then you are protected and do not need to worry. Please be sure your wife gets a thorough evaluation and is regularly monitored by a liver specialist. This is particularly important to keep in mind when you have children since HBV is very effectively transmitted from mother to baby during delivery and can be so easily prevented.

  135. I am getting into the medical field im 36 and me or my mom cant recall if I ever got the Hebatitis B Vaccination as a child. Would it hurt if I had gotten it so I know I am protected?

    • it would not hurt you if you were to repeat the series. Be sure to get an anti-HBs titer test done 1-2 months following the last shot of the series. If it is above 10 IU/mL then you are immune and protected. Hold onto the paperwork because you’ll need it for school.

  136. I received my Hep B vaccine series when I was in my early 20′s in 1982 . 15 years later in 1997 I received a booster because I am a sexually active gay man. Now, I may get back with a partner who may be a Hep. B carrier. I say that because he was falsly diagnosed with Hep. B and I am assuming it is because his blood test was positive. He was then told by other Dr. that he never had Hep. B because there is nothing wrong with his liver. I am afraid to become sexually involved with him even though I was tested for immunity last year and my titers are above 10. Is there nothing for me to worry about and just checck my titers annually or should I get another booster just to be safe if I become sexually involved with him?

    • According to your account, you should not need to worry about being infected with HBV if your anti-HBs titers are above 10 IU/mL. This will protect you from any exposure. However, I would disagree with the information your partner may have received about his HBV infection. He should have a thorough evaluation by a liver specialist to learn more about his HBV and his liver health. If he is still HBsAg positive after a couple of years then he is chronically infected and needs to be monitored regularly. The liver is a organ that may not complain for decades, so there may be no obvious symptoms and even blood work can look normal for years. It just needs to be followed to be sure he knows about his HBV and liver health. He should also take care of his liver health by avoiding alcohol, smoking and being sure to eat a healthy diet and getting regular exercise.

  137. I had my HBvaccine 1st dose on Nov 11,2013 and needs a second shot on Dec11, the problem is have to go for vacation on Dec 2-23 outside the country and be back on Dec 24, what will gonna happen to me if i missed the 2nd shot?…Please advise. Thanks

    • The time in between shots in the series is the minimum amount of time. It is fine if you need to extend the time in between shots in the series. So if you come home in January or February, you should get your second shot and then follow up with the 3rd shot with a minimum amount of time of 8 weeks between the 2nd and 3rd shot.

  138. If a person tested positive for HBsAG because they just received the vacination, how long will it be before they test negative again??

    • You should wait about a month following the vaccine before testing. In general it’s best to draw the blood and then get the vaccine

  139. I was vaccinated as a child (1980s) In 2004,IU/ I had a serology test done as part of preparations before travelling to the Philippines. The immunity levels were exactly 10 IU/ml.

    its been 10 years since and i assume the levels have fallen lower. Does the 10 IU/ml rule apply solely to people who take the test shortly after immunization or to people in general?

    • Basically. If you test someone 1-2 months after the 3 shot series and they generate a titer greater than 10 IU/mL, then they are good. you can test later, but the titers may wane with time. You know you have generated immunity, so you do not need to worry about your titers waning further. If you are exposed to HBV, your immune system would respond as it should.

  140. My sister had contact with chronically infected person through sex. She tested negative after 7 weeks and her first shot of the vaccine. Is she safe?

    • She should be fine as long as she has not re-exposed herself through sex or other direct contact with infected blood or body fluids. It may take 4-6 weeks for an infection to show up in the blood after an exposure. Be sure your sister practices safe sex until she has completed the 3 shot hepatitis B series.

  141. I took my first vaccine 2 weeks ago, my second is next month. Am i at risk of getting hepatitis b?

    • Yes you are at risk of getting hepatitis B. You need to complete the entire 3 shot series before you are completely protected.

  142. How safe am I from hepatitis B if i’ve only taken 2 shots of the vaccine.

    • After the 2nd shot of the series you have UP To 80% immunity generated. There is no way to know about your specific immunity without titer testing. Please be sure to complete the entire 3 shot series.

    • After the 2nd shot of the series you have UP To 80% immunity generated. There is no way to know your specific immunity without doing a titer test. Please be sure you complete the 3 shot series according to schedule

  143. Please i want to know that if you had hepatitis B vaccine 9/8/11,
    10/7/2011 and last 11/7/2011 how long the vaccine works on
    your system. And if you tested for hepatitis B antigen
    & antibody reactive. Can it be possible for that?

    • I’m not completely sure of the situation you are describing, but I will tell you that the hepatitis B vaccine does not work if you are already infected. So if you had HBV prior to your vaccination series, you would test HBsAg positive. HBV can be a silent disease with few or no symptoms for years, so you would not necessarily know you were already infected.

      If you are asking if you can be HBsAg AND HBsAb positive, that it is possible and there are a couple of scenarios. First confirm whether or not there is a lab error, and if not, then consult with a liver specialist and see about having an HBV DNA test run to see if you have a viral load. Timing could also be an issue if serconversion is in progress. Consult with a liver specialist.

    • The 3rd shot of the series was given too early. The minimum time between the 1st an 2nd shot is 1 month (minimum 4 weeks or 28 days). Dose 3 should be separated from dose 2 by at least 2 months (8 weeks) AND from dose 1 by at least 4 months (16 weeks). You got your 3rd shot too early. However, I don’t’ think that explains your results. I think you need to repeat the hepatitis B panel in another month to see if the results change. Otherwise you need to see a liver specialist to discuss.

  144. No I wasn’t but when prepared to come to America I went to got all the three shots . But l donoted blood and my result came out antigen reactive and antibody reactive .I can possitive?

    • Were you screened for hepatitis B prior to being vaccinated for hepatitis B? If not, then it is possible that you were already infected with HBV. The vaccine does not help those that are already infected with the virus. Please see a liver specialist.

  145. I am wondering that, if I already got Hepatitis B vaccine 3 shots in 2012; do I have to get it again? It’ s okay if I dont want to get again, because I work in school and my work require to take but I know that I already got it. That’s still work?

    • If you are in a high risk job (health care etc.) you may wish to confirm your anti-Hbs titers to be sure you generated immunity. However the series you had in 2012 should be fine. If you don’t have the records, your school or work may require that you repeat the series, so you will need to inquire. Perhaps you can get copies of your records. If you must repeat the series it will not be dangerous for you, but certainly not necessary.

  146. Got my titer checked last August 2013 bec of a needle prick incident on which result showed 18 IU/mL. My doctor said I’ve nothing to worry about since my titer is enough.

    Now on October 23, 2013 I decided to have an HBV vaccine. I know I should have received the 2nd shot by now, the problem is anytime soon I will be having a Medical Test for employment as a Nurse. You’ve said earlier that the titer should be check 4-6weeks after the shot that is the very reason why I haven’tget yet my second shot.

    For 1 shot of HBVvaccine how much immunity is generated? Though I’ve completed my 3 shot series of HBV vaccine when I was a kid. I am 22y/o now. I really want to pass the medical exam.
    Thanks! Hope to see your response.

    • Your titers were adequate when you were tested in August of 2013. If you have a copy of these test results, there is no need for another vaccination series nor is there the need for another titer test. Studies show that if you have generated immunity following vaccination, then you are good for 30 years or more (length of current studies). If you must repeat the series then I would be sure to leave at least a month in between the next shot in the series and the test you need for school and work. If a person is screened for HBV within roughly 4 weeks of being vaccinated, it is possible they will have a false positive HBsAg test. A person has up to 50% protection with the first shot of the series, but since you already generated immunity, there will be no problem for you. You do not need to followup with additional shots of the series unless you are being told that you must. It will not hurt you, but there is no additional benefit. The recent shot you already had (Oct) is a booster shot. You are good.

  147. What will happen when you – for some reasons – are not able to take the second shot as scheduled? Could it have any effect on you?

    • Getting it later than scheduled is fine, (ex. if you can’t get the 2nd shot 1 month following the first shot and instead you get it 4 months later or more, then that is fine). Do not shorten the time in-between shots in the series. That may impact your ability to generate adequate immunity.

  148. I am a dental hygienist and received the 1st heb B vaccine on 5/7/08 and the second on 8/10/09. I then went back and got another heb B vaccine on 6/1/10 which they labeled on my records as “Heb B Vaccine #1″. Do I need to repeat shots #2 and #3 to be protected? Are all the shots in the series the same or is Vaccine #1 different than Vaccine #3? Thank you.

    • no. You do not need to repeat the entire series. The 3 shots in the series are the same, so you are set, though the 3rd shot is often referred to as a booster shot. Just be sure they properly label your record or you may have a problem. Even if you had to repeat the series, it would be okay, but unnecessary.

  149. hello,
    I am 22 years old and looking back at my vaccination forms i see that i had received my third dose of hep b vaccine at 20 weeks of age; however, my previous doses were given on time. I also found a blood test taken a year after my last dose of the vaccine, and it showed that my anti-hbs levels were positive. does that mean i responded to the vaccine properly? or should i be worried?

    • If your anti-HBs titers were checked following your vaccination series and they were adequate at that time, then you should be good. You responded to the vaccine properly and do not need to worry.

  150. i had my booster dose two years ago when i was in 2nd yr college. i belong in the health care team. recently i had an incident of needle prick. i dont know if the pt is hep b positive. do i need a hep B shot as a prevention and just for assurance? i havent had a test to determine my titer level.

    • Updated recommendations from CDC just came out last month. I am assuming you have documented proof of vaccination: For vaccinated HCP (who have written documentation of a complete, ≥3-dose HepB vaccine series) without previous anti-HBs testing, the HCP should be tested for anti-HBs and the source patient (if known) should be tested for HBsAg as soon as possible after the exposure. Testing the source patient and the HCP should occur simultaneously; testing the source patient should not be delayed while waiting for the HCP anti-HBs test results, and likewise, testing the HCP should not be delayed while waiting for the source patient HBsAg results.

      If the HCP has anti-HBs <10 mIU/mL and the source patient is HBsAg-positive or has unknown HBsAg status, the HCP should receive 1 dose of HBIG and be revaccinated as soon as possible after the exposure. The HCP should then receive the second 2 doses to complete the second HepB vaccine series (6 doses total when accounting for the original 3-dose series) according to the vaccination schedule. To document the HCP’s vaccine response status for future exposures, anti-HBs testing should be performed 1–2 months after the last dose of vaccine.
      If the HCP has anti-HBs <10 mIU/mL and the source patient is HBsAg-negative, the HCP should receive an additional HepB vaccine dose, followed by repeat anti-HBs testing 1–2 months later. HCP whose anti-HBs remains <10 mIU/mL should undergo revaccination with 2 more doses (6 doses total when accounting for the original 3-dose series). To document the HCP’s vaccine response status for future exposures, anti-HBs testing should be performed 1–2 months after the last dose of vaccine.
      If the HCP has anti-HBs ≥10 mIU/mL at the time of the exposure, no postexposure HBV management is necessary, regardless of the source patient’s HBsAg status.
      Heres’ the link: http://www.cdc.gov/Mmwr/preview/mmwrhtml/rr6210a1.htm?s_cid=rr6210a1_w

  151. I missed my 3rd shot of hepa b vaccine last 2010, but recently i have discovered my records year 1990 when i was still 6 yrs old, that i have already completed the 3 vaccines. Do i need to take the 3rd dose that i missed last 2010?

  152. I started my Hep B series on Feb. 27th. I called today which is March 27th and the doctor’s office I go to is closed until Monday. Can I wait an extra week before I get the second shot? Or will I have to start it all over?

    • The time between shots in the series is the minimum amount of time. Waiting an additional week or even more is not a problem. You do not need to restart the series.

  153. I have previously received the 3 shot series about 20 years ago. Last week I had an exposure at my job which required lab work. The patient was Hep B negative so no worries there. However my Hep B titer came back at 8.7. I had a titer 6 years ago when I was hired and at that time it was 15. I am now receiving conflicting information as to what I need to do. I was originally told that I need a one time booster however when I when I got the booster in the clinic the nurse told me that I need to repeat the whole 3 step series. Later I spoke to a physician who felt that I did not even need the booster since my levels were over 10 at one point. Not sure what to think. Please help.

    • If you generated a titer above 10 IU/mL at one time, then you have generated immunity and would mount an adequate immune response if you were exposed. Had you not had a previous titer, but knew you had all 3 shots of the series, you would get a booster shot and repeat titer testing 1-2 months following the booster. If you received the booster shot or even completed the 3 shot series, it will not hurt you, but it is not necessary. Hope that helps.

  154. hussein alshareify

    Hello
    I was received two doses of HBvaccine but imissed the third dose 9 month ago then Iam injecting the last dose .so what does it considerd as athird or the first dose as the previous two doses were feld?
    Thank you

    • Additional time between shots in the series is fine. The minimum amount of time between shots in the series is what is most important. If you are late getting your 3rd shot then you are fine. Get the shot and you’re all set.

  155. Hi, I have an event booked in for the 10th of May, it is required that I’m up-to-date on my hep b vaccinations, I did receive these in school but was unsure if I had received all 3 series, about a year ago my doctor let me know that my hep b was a little low, I don’t have the results anymore so I’m not sure how below the the 10 I am, so I went and got the first hep b needle on the 25.3, I’m not sure if I’m protected or not, but I’m wondering if I got the booster needle now would it take affect and cover me for this event on the 10.may?

    • on April 25, consider getting an anti-HBs titer test repeated to see if you responded to the booster shot you received on March 25th. If you did not respond, then be sure to get the 2nd shot of the series. Most likely you will respond to this booster shot if you believe you received all 3 shots of the series previously. Can’t say for sure about your coverage, since I don’t really know your situation. However, in general, after 1 shot you have up to 50% immunity generated and after the 2nd shot you have up to 80% immunity generated. If you had generated immunity previously but hadn’t tested, you might be fine now. Hard to say for sure, but most likely you will be okay.

  156. Hi, i have read the forum posts and found out that i need to get tested to see my hep b antibodies levels. so if i go for a hep b titer, i get informatio about (Anti-HBs), (Anti-HBc) and (HBsAg) or the titer only tells you information about the IU/mL value.

    i met someone who has has chronic hep b and also has liver cancer, i have had the 3 dose vaccination. the main concern is that if i do the test and get less then 10IU/mL should i get the booster or the hemoglobin. Also, if i have sexual contact with her, should i have the booster or hemmoglobin vaccation even if i have more then 10IU/ml or am immune from hep b. thanks

    • If you are getting a titer test to check your HBV immunity then you want to get an anti-Hbs titer test (HBsAb). If you were vaccinated years ago it is possible that your titers have waned over time. If they are below 10 IU/mL then get a booster shot of the HBV vaccine and repeat the titer test in a month. Until that time be sure to practice safe sex and avoid direct contact with blood.

  157. Thanks for the reply will do, if I’m still a little under, and I get the booter shot, how long till it becomes effective? Immediately?

  158. Hi, I have documentation of receiving the first HepB shot in 2006, then in 2008 I received another HepB 1 of 3 shot from another doctor. My family moved so they must not have gotten the record of the shot from the previous healthcare provider. I need to complete the series to apply for a CNA program but I’m not sure if I need to take shots 2 and 3 still or just 3 because Iv had two shots labeled as 1 of 3.

    • You can resume with getting the 3rd shot of the vaccine series. The amount of time in between shots of the series is the minimum amount of time between shots in the series, so an extended time between shots in the series is fine – even years. However, if you must repeat the entire series for your job it will not hurt you. I would encourage you to get an anti-HBs titer 1 to 2 months following the last shot of the series to confirm that you have generated adequate immunity. Often this is a requirement when working in health care. The timing of the titer is important so please get it 1 -2 months following the last shot. Keep a copy of your titer for your records.

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