Diagnosed With Chronic Hepatitis B? What Does Your HBV DNA Test Tell You?

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If you have recently been diagnosed with chronic hepatitis B, your liver specialist is running a series of tests over time to determine if you are a good candidate for treatment. Remember, not everyone benefits from treatments currently available to chronic HBV patients.

Since you are chronically infected, you know your hepatitis B panel most likely shows that you are:

HBsAg positive/reactive,

HBcAb positive/reactive

HBsAb negative/non-reactive

The last entry in this series looked at the HBeAg (HBe-antigen) and HBeAb (or anti-HBe antibody) tests, and what they mean if they are positive or negative, giving you a good indication of the replication activity of the virus and how infectious you are. The HBV DNA test or viral load test takes this a step further by quantifying the amount of HBV DNA you have at the time of the blood draw.

Simply put, the HBV DNA test indicates how much of the HBV virus is circulating in your blood. This test, over time, can give a good idea of the hepatitis B replicative activity in your liver. The virus is released into your blood, which can then drawn and analyzed by the HBV DNA viral test.

These viral load test results may be used to help determine whether or not treatment is recommended.  If you are HBeAg negative, and your viral load is above 2,000 IU/mL, treatment may be recommended. If you are HBeAg positive, treatment may be recommended if your viral load is above 20,000 IU/mL. Please note that these are guidelines. There are other factors that come into play when recommending treatment, such as ALT and other liver function tests, liver diagnostic information, age, family history, and more.  It can be complicated, so the importance of a liver specialist cannot be underestimated.

The viral load test results may also be monitored to determine treatment response. This is particularly true with the use of antivirals. Antivirals work by stopping replication of the virus. If your viral load decreases significantly or becomes undetectable, then you are having a favorable response. If your viral load goes down and eventually begins to elevate again, then it may indicate that you have developed a resistance to the antiviral you are taking.

The HBV DNA test is performed using a Polymerase Chain Reaction (PCR), a technique used for rapidly generating DNA fragments so your HBV DNA can be analyzed. It’s a sophisticated, but common test, and it’s a complicated if you don’t work in the lab. There are different techniques, so you will likely see reference to the method used for your test such as “real time”  (RT) PCR or TAQMAN. This shouldn’t really matter unless you are in a clinical trial, where consistency is very important when analyzing results.

What does matter for comparative purposes are the units of measurement. The viral load test is typically measured in the units IU/mL or international units per milliliter. Previously it was measured in copies per milliliter, and sometimes those units are still used. When comparing, it is important to be sure the units are consistent from one test to the other.  In case they differ, there are about 5 to 6 HBV DNA copies per international unit, so you can do a basic conversion and compare your results over time.   Remember to keep copies of your lab information on file so you can track your status. An Excel spreadsheet works great.

The sensitivity of the HBV DNA test may vary with the lab, but the low end of the range is typically 300 IU/mL or less. Below the threshold of the test, the viral load is considered “undetectable” – something everyone with chronic hepatitis B wants to hear.

How the results of the test are displayed mathematically on your lab results can be confusing.  Because the amount of virus in the blood may be very high – in the millions or billions, the result they may be displayed as an exponent or a log, rather than a whole number. If this is confusing to you, please take a look at this explanation on the math.

The range of the viral load numbers vary greatly from person to person, and over time the viral load will likely vary with each individual. Young children may have viral loads in the hundreds of million or even billions.  It sounds scary, but that is not unusual, and kids have different treatment guidelines. The viral load may remain very high for decades depending on how your body is responding to the virus. This varies with the person and the genotype.

It is important to remember that the viral load test provides you with important information, but it must be read in relation to your other HBV and liver function test results in order to determine if treatment is a good option, or if you are responding favorably to current treatment.  Although an undetectable or low viral load is considered favorable, it does not necessarily guarantee that you have not, or are not experiencing liver damage.  Hepatitis B is a tricky virus. Talk to your liver specialist with your HBV specific questions.

469 Responses to Diagnosed With Chronic Hepatitis B? What Does Your HBV DNA Test Tell You?

  1. Viral load is 310IU/mL.what treatment can i take?

    • 310 IU/mL is very low. Your liver specialist may wish to look at how your viral load changes over time, but based on this number alone, it does not appear that you would benefit from any treatment at this time. Please talk to your liver specialist.

    • Likely no treatment. Your viral load is very low. You would not benefit from currently available treatments. Talk to your liver specialist if you have additional questions.

  2. WOW. Some very complicated information explained in a user-friendly way. Thanks!

  3. About a year ago I was noticed that I was a HBV carrier. Actually, my HBsAG remains pozitive and HBsAB negative. The SGOT-AST is about 22.3 whereas the
    SGPT-ALT is 20.5 and GGT is 13.7
    Am I still contagious to others?
    Is there any chance I can overcome this virus?

    • Since you remain HBsAg+ for the last year, you are a chronic carrier of HBV. From your information, it is impossible to know how infectious you are. You would need to have an HBV DNA test run as described in the blog. A good indicator would also be your HBeAg results. Regardless, please be sure you are taking basic precautions and avoid direct contact with HBV infected blood and body fluid. If you have open cuts, sores, or bites, please keep them covered to avoid exposure to others. Please be sure all sexual partners are vaccinated, or be sure to use a latex condom to avoid transmission. Keep all personal hygiene products away from others to avoid accidental use of razors, toothbrushes, nail clippers or anything that may have microscopic blood that may transmit the virus. Please be sure all close, household members are vaccinated. At this time there is no complete cure for HBV, though there are good treatments. Please be sure to be monitored regularly by a liver specialist. Based on blood work and other factors, he will be able to tell you if you are a good candidate for treatment.

  4. I test my blood last week, the result was not so good.
    AST (GOT) = 65 (normal <40) U/L
    ALT (GPT) = 68 (normal <40) U/L
    GGT =21 (normal <40) U/L
    HBeAg 1004.00 (<1) (s/co)
    and my HBV DNA TEST IS 47.000.000 IU/mL
    I also do fibro-scan
    After diagnosis the doctor does not recommend me for treatment.
    what do you advise me on that case?

    • It is important to confirm that you are chronically infected and have been HBsAg+ for more than 6 months. 90% of those acutely infected resolve their HBV on their own and very few require any treatment or intervention. If you are chronically infected then it is different. I do not know your age, and I assume you are female, but the a normal ALT is now considered 19 for women and 30 for men. Your viral load is high (47,000,000) if you are an adult with a chronic infection. If you are chronically infected, please make a copy of the AASLD guidelines for treatment referenced in the blog and bring it to him so you can discuss the possibility of treatment. If you are acutely infected, then please be patient.

  5. hi there, i ve been diagnosed to be a hep b carrier just over 6 years ago.i am 34 years old with 3 children under 6 and i worry about it a lot.i am under hep b foundation here in NZ evn thou i dont come from NZ thou.just tought i ask for a second opinion.my last results from october 2012 are-hep b surface antigen-positive
    hep b e antigen-negative
    alpha fetoprotein 1.3 ng/ml
    alanine aminotransferase 12 U/L
    gamma glutamyl transferase 9 U/L
    total bilirubin 16 umol/L
    alkaline phosphatase 92 U/L
    albumin 47 g/L
    total protein 75 g/L
    from what i understand,the virus is in the blood but is not replicating.just dont know if i should seek some treatment or just do nothing and hope it wont wake up one day!its always on my mind.could u pls give me an advice.thank you Sonia

    • You are HBe negative and have a normal ALT, so you likely have little or no replication, and are likely in the inactive phase. If you want to know for sure, you could have an HBV DNA test done to see how much virus there is. Regardless you should continue with monitoring for liver cancer (AFP testing) every 6 months along with LFTs. An elevated ALT in the absence of a viral load will give you an idea if you have developed an HBe mutation. It doesn’t always happen, but if you do do develop an HBe negative you mutation, your doctor will likely start you on treatment. Sometimes it takes a while diagnose so be patient, and try not to worry about something that may or may not happen. Continue monitoring, make healthy lifestyle choices and live your life to the fullest!

  6. My blood test done and that found hbsag positive
    my hbv dna viral load is 157000
    sgpt 79
    sgat 53
    hbeag negative
    anti hbe positive
    fibroscan result 6kpa I have a chronic hepb kindly give me my liver status can i live a but previously i do not know about that because i feel healthy and i have some symptomps of active liver deasease also I started enticavir0.5

    • Be sure to continue monitoring with your liver specialist. Your SGPT is elevated and your HBV DNA viral load remains high, but it should come down to normal ranges if you remain on entecavir which is an excellent antiviral. It does take time, so please be patient and continue monitoring. If you have additional questions, please talk to your liver specialist.

    • Assuming you generated adequate immunity following your vaccine series, then you are good. However, depending on your risk in your health care job, you might like to have your anti-HBs titres checked. If they are below 10 IU/ml, then get a booster shot and have your anti-HBs titres rechecked one month following your booster to ensure adequate immunity.

  7. Can milk thistle or silymarin cure hepa b virus?

    • Milk thistle will not cure hepatitis B. it is an herbal supplement that was thought to help reduce inflammation of the liver. it did not fair well in trials and there was no evidence of a benefit. It does not do anything to reduce the amount of circulating virus.

  8. I am 38 years old, and current pregnant for three month. My ALT is 347, AST is 167, and my Hepatitis B DNA Viral Load is 1.43E+7IU/ML…. Does my life in the dangers line? Should I start taking the medicine like Viread? please help…

    • You really need to see a liver specialist immediately. You sound as though you might well benefit from treatment, and likely your baby would too, since it looks like you are probably HBeAg+, with a high viral load. Your ALT/AST levels are also high. Tenofovir/Viread is an excellent antiviral and recent review of data show it may be a very good option for pregnant, HBV+ moms in need of treatment and to prevent transmission of the virus to their newborn.

  9. Hi, my name is Kabiru 31yrs old male. I was tested HBsAg => Reactive
    HCV => Non Reactive
    Total Protein ~ 65
    Albumin ~ 36
    Alkali Phosph ~ 11
    AST ~ 11
    ALT ~ 04
    Total Bilirubim ~ 0.43
    Direct Bilirubim ~ 0.27.
    My liver is normal in size with a cranioccudal span of 14.4cm at the MCL. It shows narmal parenchymal echogencity and smooth outline.
    The gallbladder, spleen (7.9cm), paraortic bed and paraortic area are within normal
    Both kidneys are normal in position. In conclussion, essentially a normal examination.
    Dated 5th December, 2012.
    Sir what should I do?

  10. my mother.49yr.was diagnosed as cirrhosis of liver on USG.she has HBSag (+).HBE ag(-)&anti HBe(+).HBV DNA load is 2000000 IU/l.but she is still asymptomatic with normal AlT & AST.Which antiviral drug be the best for her?How ‘ll the response be?.if I start antiviral now,is there enough time not to change HCC.I want to know the average life expectancy.plz….answer me.I am so sad..I can’t live without her.btw,I am from Myanmar,Asia.

    • Please try not to let your worries consume you. The best thing your mother can do is to be thoroughly evaluated and regularly monitored by her liver specialist or a doctor with experience treating HBV. She is still HBeAg + with a high viral load, so you will want to talk to her liver specialist to see if treatment with an antiviral such a tenofovir or entecavir would be a good option for her. There is no true way to predict who will develop HCC and who will not. Your mother’s liver specialist will know best. Regular monitoring, screening for liver cancer, following prescribed treatment, and healthy lifestyle choices are certainly important.

  11. hepb sag +
    hepb e ag -
    hepb e ab +
    hbv dna load – hbv dna not detected
    (quantitative real time pcr specific for HBV DNA)

    I was vaccinated for hbv 13 yra ago and all 3 doses were taken. those days I was hbv sag nrgative.

    what is my status and can I get rid of this?

    • It looks like you currently have HBV,though you appear to be in the inactive stage of the virus since you are HBeAg neg and you have an undetectable viral load. Most likely you have had HBV for some time. Hard to know what did or did not happen 13 years ago. Were you really HBsAg negative, or was there a recording error at that time. The other possibility is that you never generated adequate immunity when you were vaccinated years ago. A certain portion of the population are vaccine non-responders. Unless you verified immunity with an anti-HBs titre test, there would be no way to know and this test is not run unless ordered.

  12. is there a possibility that I transfer the virus to another person?
    is this harmful to my health and can the virus be active again

  13. is there a possibility that I transfer the
    virus to another person?
    is this harmful to my health and can the
    virus be active again?
    is there a way I can get rid of this virus and make sag negative?

  14. hi my name is haseeb i from pakistan i have reactive hbsag since last five years but my pcr is normal and antibody is normal sgpt is 48 what is shoud can i treatment

    • It sounds like you would benefit from the evaluation of a liver specialist. You are HBsAg positive, which means you have a current infection. The PCR is typically given quantitatively. The hope is to have an undetectable viral load. I’m not sure if that’s what you mean by normal. You say your antibody is normal. Do you mean HBeAb or HBsAb? Your SGPT of 48 (assuming IU/mL) is a bit high since a normal ALT is 30 IU/mL and below. However, your ALT can be elevated for other reasons besides HBV. I would encourage you to talk to your liver specialist.

  15. my sister age 23 has HBV VIRAL LOAD <3.8. IS she has any problem. what is its reference range.

    • It appears that her viral load is low (<3.8), though I have no idea of the units?? I would encourage her to speak with her liver specialist. A thorough evaluation involves much more than a single HBV DNA viral load test.

  16. My hbeag neg hbeab pos and hbvdna value 81 iu/ml pl ans me these normal range or not.

    • You want to discuss your results with your liver specialists. The state of your HBV is not determined with a single set of labs. It looks like you might be in the inactive stage of the virus since your viral load is low. However, this really needs to be looked at along with your liver function tests. Although your viral load is low, having any viral load is not “normal”. Please continue monitoring with your liver specialist.

  17. Does the future look promising in regards to finding a complete cure for Hepatitis B? Is hoping for a cure within the next 10 years too optimistic?

    • This is Hep B Talk’s opinion, but yes, I am optimistic. However, it may take some time to get a safe and fully effective “cure” to market. The process takes time.

  18. I am hbsag +ve,hbeag -ve,DNA viral load is lower than(<6) undetectable limits.What are the possibilities of spreading the infection to my partner,he is not vaccinated before.Doctor has not suggested me any medicine.Do i need to take any medicine

    • There are algorithms and guidelines to determine if someone would benefit from treatment that your doctor is likely using. Other health issues and family history also factor into whether or not you should be treated. However, you have an undetectable viral load, so current antiviral therapies would not benefit you since you appear to be in the inactive phase of the virus. Please continue to be monitored and please be sure your partner is screened and then vaccinated to protect against hepatitis B. Your status could change, and with a safe and effective vaccine, why would’t you be sure to have your partner vaccinated?

  19. I have recently discovered that I have Hep B and do not see a specialist for 4 more weeks. What do the following lab results indictae for me;
    HBsAg positive, HBeAg negative, HBcAB (IGM) negative, HBcAB (total) positive, HBeAB positive, HBsAB <0.1. HBV 7800 copies/mL and my ALT is 114 (normal below 40). Also my serum tumor marker is 1.6 (0.0-8.3 refernec range).

    • Your HBcAb -IgM (neg) indicates that you likely have a chronic infection rather than an acute infection, but wait to verify with your liver specialist. Your ALT is elevated. Normal for women is 19 IU/mL. This means your immune system is fighting the virus, but without more testing and time, I can’t say if you’re actually trying to resolve an acute infection, just recently serconverted losing HBeAg, or if you have HBeAg negative HBV and are experiencing a flare. Try not to panic. It may take a little while to figure this out. However, your liver specialist will have a much better idea after he does a thorough evaluation. Try to be patient. While you wait, avoid alcohol and smoking and eat a healthy, well-balanced diet. Avoid fast and processed foods. Don’t forget plenty of good, clean water and a little exercise. Take precautions with sexual partners and close household contacts.

  20. i have hepb DNA as 3148 iu/ml. Dr.Told me no treatment for me. How many years I am going to live on earth because i am 23 years? poor person no family.

    • It is impossible to predict how your HBV will impact your longevity. Many people with chronic HBV die from something totally unrelated to hepatitis B. Many live very full, long lives with family, friends, and a career. However, HBV can lead to liver damage, which can of course impact your life, and HBV does put people at greater risk for liver cancer. Continue regular monitoring with your liver specialist to determine whether or not your stage of the virus changes and you become a candidate for treatment. You also want to be tested for liver cancer.Those that do not benefit from treatment will benefit from living a healthy lifestyle. Be sure to avoid alcohol and smoking and maintain a healthy weight by eating a well-balanced diet. Don’t forget that exercise is also good for your liver. Please take care.

  21. Joseph my liver function tests are okay only s-Albumin which is 34g/L its low normal rate is 35-48. But my question is How many years am i going to live.

    • THere is no one – not the best doctor in the world, who can predict how long anyone with or without HBV will live. Please try to focus on the positive things you can do for yourself and the healthy lifestyle changes you can make to improve your life!

  22. Thank you so much for the information and for your quick reply. The information you provided makes it easier not to panic. One more question, while awaiting answers from my doctor, what signs or symptoms should alarm me to seek medical attention urgently. I have been sick for a few weeks and it seems to be progressively getting worse most days.

  23. Amy, If you continue to feel worse, I would check in with your doctor. At most you’ll likely need only supportive care, if you need anything at all. Your doctor will run some blood work to make sure everything is okay. The liver is basically a non-complaining organ, but if you notice jaundice (yellowing of skin or eyes), bloating or swelling of the abdomen, or you experience severe nausea or vomiting, you really want to get to the doctor straight away.

  24. I am 32 yrs old.
    Hbsag+
    Hbe-
    HBV DNA-54550
    SGPT-60 normal range-42
    Which antiviral medicine can I use?
    Thanks,

    • Talk to your doctor about the possibility of an antiviral with a good resistance profile such as tenofovir or entecavir. These are both excellent antivirals.

  25. my dna viral load one month before was 1115 UI/ml after one week it became 4865 ui/ml my Alt is elevated does it mean mu virus is active??

    • Please try not to worry too much. It sounds like you may be in an active phase of the virus. Please be sure to talk to your liver specialist about your questions. He has a better understanding of what is going on with you particular situation. Call and make an appointment and write down any questions you may have for him.

  26. im very tense my omam visa depends on iy plz relly soon

    • Please check to see what the requirements are for a work visa in Oman. Some countries like UAE may not permit you to get a visa if you are HBsAg+. I do not know the requirements for Jordan.

  27. the dna shows that my friend has about 7,000copies/ml and liver function result shows normal,can he start treatment.

    • Your friend will want to discuss his situation with his liver specialist. Determining whether or not treatment is recommended is not based solely on the viral load, and may be determined after monitoring over a period of time. Remember that treatment is a big commitment. Please have him discuss with his specialist.

  28. I am Hbsag +ve with HBeag -ve with undetectable viral load,currently iam in inactive phase of infection.I delivered a baby 5 months back and he got vaccinated for hepatitis b immuneglobin(HBIG) and hep B vaccine after 15 hours of his birth,but in many sites i have seen that the vaccines should be given with in 12 hours of birth.Is my baby at risk of having hepatitis b.

    • Your baby should be just fine! Please try not to worry. However, it is suggested that you have your baby tested at 1 year, or 18 months to be sure there is adequate immunity to hepatitis B as a result of the birth dose of the vaccine and the shot of HBIG.

  29. I am in inactive phase of hepatitis b(hbsag +ve,hbeag -ve and undetectable viral load,LFT is normal),Can I cure this hepatitis b with any vaccine and get it negative

    • The HBV vaccine does not help those that are currently infected with HBV. You are in a good place with your HBV, but monitoring of your HBV and continued surveillance for liver cancer remain important. At this time there are no treatments for those in the inactive phase of the virus.

  30. I know there is no cure for HBV, but can a chronic carrier go into remission or something, or will I be contagious forever?

  31. HBsAg positive
    HBcAb positive
    HBsAb negative
    DNA load less than 20
    above condition is after taking tenfoveer (cipla) medicine from more than two year ..now my familiy want mariage ..what precaution should be taken after mairage ..should i do mairage or not..Hepetais will be negative or not..how many time we have to take medicine.thanks

    • You are having an excellent response to tenofovir. It is great to see that your HBV DNA viral load is not detectable. There is no reason your HBV should stop you from getting married. I would encourage you to have your spouse vaccinated with the 3-shot series before marriage to ensure protection against infection. More and more studies show the benefit of taking antivirals for years or even for life. EASL guidelines from 2012 discussed the consideration of stopping antivirals after the patient loses HBeAg+ and gains the antibody at LEAST 1 YEAR following seroconversion and loss of HBe and complete suppression of the virus. If it has been at least a year, then have this discussion with your doctor to see what he thinks. If you had been diagnosed with HBe negative hepatitis B, then doctors would likely keep you on tenofovir indefinitely. Please have this conversation with your doctor. Do not go off of your antiviral without his input. You would require very close monitoring of your viral load and other tests to be sure your viral load does not elevate and to prevent a potentially dangerous flare. Once again, you are having a great response to tenofovir and there is no reason your HBV infection should keep you from getting married and having a family.

  32. hello I have hepatitis b .my test value are
    hbsag + hbeag +
    sgot/spot-80/88 and viral load is to high my age is 27. pl ease tell me what I am good candidate for taking madicine

    • I would encourage you to discuss the possibility of treatment with your doctor. You are HBeAg positive, your ALT is elevated (ULN men, 30 IU/mL, ULN women, 19 IU/mL) and you have a high viral load. There are other reasons a person may have elevated ALTs, and your doctor will be able to determine whether or not your elevation is a result of your HBV or something else. Please discuss your details with your doctor.

  33. I was diagnosed with chronic Hep B infection with virals as follows;
    HbsAg – positive
    HbeAg – negetive
    Anti Hcv – negetive
    Hiv screen – negetive
    HbsAb – negetive
    HbeAb – negetive
    HbcAb – positive
    Hbc Igm – negetive
    Abdominal Ultrasand scan shows liver spans 117mm, gall bladder-normal in content and wall thickness. both kidneys are normal in size scan result shows liver.
    please what does this imply? how severe is it plus what steps should i take?
    Thank

    • Since you have been diagnosed with chronic HBV, you may be in the process of seroconverting losing HBeAg and gaining the antibody. You will need to repeat your HBeAg and HBeAb tests in a couple of months to confirm if the seroconversion occurred. You might want to talk to your doctor about having an HBV DNA viral load test run at the same time. Talk to your doctor about your results after the next round of testing.

  34. hello
    could you explain me please:
    hepatitis b surface antigen DETECTED
    hepatitis b core antibody DETECTED
    hepatitis b e antiboddy DETECTED
    HBV viral load: 4938 IU/mL
    log (10) viral load: 3.70
    Is my imunne system working against it or not?
    Thank you.

    • Please talk to your doctor about your results. Can you tell me if you have an acute or new infection or a chronic infection? This is often diagnosed when a person tests HBsAg+ for more than 6 months. You’ll get a better indication of whether or not your immune system is fighting the virus based on your ALT/SGPT. An elevated ALT for women is greater than 19 IU/mL.

  35. Thats the problem i dont know which HBV i have got…and im pregnent…

  36. I have tested negative (.82) on the surface antibody, negative on the antigen and positive on core antibody. I read this is unusual. I did it through labcorp. I have a doc appt next week. I read that a possibility with those results is that the positive could be false. I was immunized 10 years ago. If the antigen is negative, does that mean I am or am not contagious? And is a booster recommend? Thank you!

    • It’s possible it’s a false positive. It is a bit unusual because HBcAb would indicate that you had a current or previous infection. If you had a current infection, you would be HBsAg +. If you had a past infection that you resolved, you would most likely be HBsAb positive. it’s good that you’re going for additional testing. A liver specialist will clarify the situation. Most likely he will recommend a booster to see if you can generate immunity, Check anti-HBs titres one month after booster shot.

  37. Hi Every one,

    Please Help me to Understand my health condition. I am 32 year old, Never Married

    I had test vital load 1 year back, it showing “less than detection value”
    But now it is showing 1943 IU/Ml and HBs Ag Reactive,

    What is this mean ..? did i required any treatment ??
    How bad my health condition ?? Any way to reduce my vital load.
    My parents are forcing for marriage .. can i marry the girl who has effected HBV ??

    Thanks in advance
    ravikumarpallavali at gmail.com

    • it is not uncommon for the viral load to fluctuate, but your doctor will want to monitor you to see if you have moved out the inactive phase and into an active phase. I am assuming that you are HBeAg negative, so if your viral load continues to elevate, you will want to talk to your doctor about the possibility of going on an antiviral. Tenofovir and entecavir are excellent antivirals. Your doctor will give you a better idea of your healthy condition by reviewing your blood work, ultrasound, physical health and family history. Please be sure future partners receive the HBV vaccine to protect them against HBV. Until your future partner is vaccinated, please be sure to practice safe sex since HBV is transmitted with direct contact with infected blood and body fluids.

  38. please,tell me,if some how some one can help me,it looks like i cant never get rid of this virus…how its gonna be with the baby…what about my husband?he said he is vactinated but he never been testes for this HBV…so im really worrie…

    • It is true that at this time there is no complete cure for HBV. Fortunately there is very effective prophylaxis in order to prevent the transmission of HBV from an infected mother to her baby during delivery. You will want to talk to your doctor to be sure that the first shot of the HBV vaccine and a shot of HBIG is available at the hospital when you give birth. The baby needs to receive these two shots within 12 hours of birth in order to prevent transmission. This is effective 90-95% of the time. If you are HBeAg+ and have a very elevated HBV DNA viral load, please talk to a liver specialist since HBV transmission can be prevented through the use of antivirals during pregnancy. As for your husband, if you are not sure he is vaccinated, please be sure he gets a hepatitis B panel so he can determine if he has a current or past HBV infection, or immunity to HBV. Please try not to worry too much. There are some great options for you and your baby!

  39. I have a test result of HBV DNA of 1557 IU/ mL. What does it mean and does it require treatment?

    • I would encourage you to be evaluated by a liver specialist so you can learn more about your HBV and your liver health. Regular monitoring is very important. Your viral load is not too high, but there is more to the diagnosis than just your viral load. Please make an appointment with a liver specialist for further evaluation.

  40. Please help me to understand my result about the hbv DNA, I’ve been diagnose hep b but my hbvdna test now is 48iu/ml 278 copiesml… Tncs

    • Assuming you have chronic hepatitis B where you have tested HBsAg+ for more than 6 months, then I would say that you are in the inactive phases of the virus. Your viral load is very low, which is good. Be sure to continue regular monitoring to be sure there are no changes to your HBV and liver health. You also need to be sure to be monitored regularly for liver cancer.

  41. Ii undergo some test and my result is 40iu/ml 233 copies/ml. What does this mean?do i have a chance to be cured? How?pls help me….thank you so much..

    • If you have a chronic HBV infection (one where you have tested HBsAg+ for more than 6 months) then there is no complete cure. Though I don’t know any of your other data, I suspect you are in the inactive phase of the virus and likely HBeAg negative with a very low viral load. This is a good place to be since you have a very low viral load, but unfortunately most of those with chronic will not seroconvert losing HBsAg and gaining the antibody with an undetectable viral load. Be sure to continue seeing your liver specialist regularly to be sure HBV and liver health remain good.

  42. My current Hep B results are:
    HBsAg Positive
    HBe Antigent Not detected
    Anti-HBe Positive
    HepB DNA not detected
    What is the indication of these results?
    And how infectious am I?
    Please help

    • It sounds like you are in an inactive phase since you are currently HBeAg neg, HBeAb pos, HBsAg pos and you have an undetectable viral load. This is a good place to be. Please be sure you continue to be monitored to be sure your HBV and liver health remain good. Like everyone else with chronic HBV, you should be screened for liver cancer

  43. I hav HBV and my viral load test result is 225202 iu/ml,
    low positive is 100-1000 iu/ml
    high pos is 320000-3200000iu/ml what should i do and what is my condition with d result displayed above?

    • I would encourage you to speak with a liver specialist about your elevated viral load. Please note that treatment is not decided by viral load alone. Young people tend to have very elevated viral loads, but they may remain in the immune tolerant stage for decades. This might be the case for you if your ALT is perfectly normal and you have no evidence of past flares. At some point, many specialists will put a patient on an antiviral, even if they are in the immune tolerant stage, but you will want to sit down with your doctor to have this conversation. Most likely an antiviral would be your best option – preferably one with a good resistance profile such as tenofovir or entecavir.

  44. My liver functions test were all fine .
    I did gastroscopy three months ago and everything looks great
    And i did ultrasound last month and it all looked good plus the above results
    Ghanks

    • Glad to hear your liver function tests are within normal ranges and your ultrasound and endoscopy is good. You do not mention any of your hepatitis B lab results such as HBeAg, HBeAb, and HBV DNA viral load.

  45. Hi,

    I have been diagnosed with HBV and my Viral Load was detected to 30 IU/ml i just started treatment, i was giving weekly injection for 8 weeks now and the result viral lad test result received today shows <2.06 copies/ml
    (The detectable viral load was less than 116 copies/ml)

    What does this result show?

    • I don’t know what injectable you would have been prescribed for 8 weeks. Patients with an ALT at least 1.5 times greater than the upper limits of normal (ULN) and a lower viral load might be prescribed PEG, but that would be for 6 months or likely a year. It would also be very, very unlikely that you would be prescribed an antiviral with such a low viral load of 30 IU/mL. So your result shows that your viral load went down, but it is already, very low.

  46. justify myself!

    here are my results;
    hbsag 10493.0 reactive
    anti-hbs <2.0 non-reactive
    hbeag 0.066 non-reactive
    antihbe 0.007 reactive

    hbv load – 64copis/ml
    11 ui/ml
    am i a good candidate for tenefovir?

    • Please talk to your doctor, but since you are HBeAg negative and have a very low viral load, it seems very unlikely treatment would benefit you at this time. You appear to be in the inactive phase. Antivirals work by lowering the viral load to very low or undetectable levels and you are already there. Please continue monitoring through your liver specialist to ensure your situation does not change.

  47. I have a chronic hep b
    Before starting my treatment with enticavir
    My results are Hbsag +ve, Hbeag -ve, Anti Hbe +ve and sgpt 80 sgot 79
    Hbv Dna viral load is 157000 IU/ml. Now after taking 6 month of m
    medicine enticavir 0.5. My results are Hbsag +ve, Hbsab -ve, Hbeag-ve, anti hbe -ve, HBV DNA viral load is <20IU/ml, sgpt 27 sgot 32.
    I kindly request you to give me complete information about my hep b status is right now i am in inactive phase of hep hep b kindly help me.

  48. Hello, I am being treated with adefovir and telbivudine. I contracted this whilst working in a nursing home cleaning toilets! My viral load has been completely undetectable for 2 and a half years after the telbivudine was added. I phoned the hep b foundation and was told that unprotected oral sex is fine if the viral load is undetectable. Could you re-confirm this or should I be telling everyone I have oral sex with?! I never have unprotected penetrative sex with anyone. Would appreciate some advice

    • Oral sex should be safe unless the parties involved have a very high viral load or mouth sore, bleeding gums, etc. Your viral load is undetectable so you are good. Be sure to continue monitoring of your HBV with your liver specialist

  49. I posted a comment on 1st june 2013 at 4:42 am
    It was mistakenly typed anti hbe -ve by me. Kindly read it anti hbe +ve.

  50. Those are the tests results:
    HBs Ag: reactive
    HBs Ab: non reactive
    HBe Ag: non reactive
    HBe Ab: reactive
    HBc Ab (IgG): reactive
    HBc Ab (IgM): non reactive
    HBV-DNA quantitative: 94406 lU/ML
    HBs Ag quantitative: 581.7 IU/ML
    Liver function test: All normal
    X-ray: everything is normal

    I didn’t start any treatment.

    What is the indication of the result?
    And how infectious am I? Should I take medication or not?

    • Your tests tell you that you have a chronic HBV infection. HBeAg is negative and your viral load is 94,406 IU/mL. This most likely indicates that you have HBeAg negative hepatitis B. Talk to your doctor about your viral load and see what your ALT levels are. Tenofovir and entecavir have the best resistance profiles of the available antivirals. I would encourage you to talk to your doctor and see if he is considering treatment for you at this time.

  51. I am HbsAg positive.. Discouvered 10 years ago .. Normal liver function.. HBV DNA count is 1.7 X 10^3 ( 1700 ) IU/mL
    I did a CBC with absolute neutropenia and lymphocytes is 65
    Should i start tenofovir medication or not?

    • I would encourage you to get a thorough evaluation from a liver specialist and talk to him about whether or not treatment would benefit you at this time. Your viral load is not very high, so unless there are other factors in play (family history, HBeAg negative HBV, elevated ALT/AST or other liver function tests, evidence of liver damage with ultrasound or other means) it would seem you would not need treatment at this time. Please talk to your doctor since he has all of your labs and health history available to him.

  52. How often should i do a viral load Measurement?

  53. Hi,
    I was given a Hep B test result as follow:

    Hep B surface antigen— Reactive
    Hep B surface antibody— Non-reactive (.12 mIU/mL
    core total (IgG+IgM) antibody— Reactive
    core IgM antibody— non-reactive
    Hep B “e” antigen— non-reactive
    Hep B “e” antibody— Reactive
    Hep B DNA Viral Load— detected: 8.29E+4 IU/mL
    *1IU/mL=5.28 copies per mL

    My question is what does the viral load number 8.29E+4 IU/mL mean? Is it (8.29*10^4 = 82 900 IU/mL)?? And what does this represent. Does that make me infectious to other people and to what degree? What I be a good candidate for drug therapy? I have had ultrasound done and it came back clean with no sign of damage. I am seeing a specialist in a couple or weeks.

    • Based on your results it appears that you have a chronic HBe negative hepatitis B infection. Your viral load is 82,900 IU/mL – you calculated it correctly. I don’t know what your ALT or SGPT looks like, but often when the viral load elevates to a level like you see with someone HBeAg negative/HBeAb positive, you would want to talk to your doctor about the possibility of treatment with an antiviral. This is a once daily medication with something like tenofovir or entecavir. Please take precautions by practicing safe sex with all partners unless they are vaccinated to protect against HBV and take care to avoid direct contact of infected blood with others. Be sure blood spills are carefully cleaned with a diluted bleach solution. Take care and do not share personal items such as razors, toothbrushes or nail clippers. They can have trace amounts of blood on them and HBV lives on surfaces for as long as a week. Be sure those you are in close contact with are screened for HBV and vaccinated if they do not have HBV.

  54. Hellow sir,

    My viral Load was 406 IU/ml on Feb-13 and I had the same test on 14th june It was 32IU/ml. It was reduced a lot.
    My wife and 2 years daughter have negitive and done vaccinated successfully.
    1.Can I go for 2nd kid as my wife have vaccinated.. ?
    2.Can I cure completely because my viral load has reduced a lot.
    3.As on 17.12.12 SGPT-79 SGOT-48
    As on 6.1.13 SGPT-86.3 SGOT-37.7
    As on 22.4.13- SGPT- 59 SGOT-45

    Kindly Guide me sir

    • You may be surprised, but a person’s viral load can fluctuate quite a bit and changes less than 1 or 2 orders of magnitude mean very little. However, lower is always better, and your viral load is very low and your HBV would likely be considered inactive. I am very glad to hear that your wife and child have been vaccinated to protect them against HBV. Was your wife ever screened for HBV? Assuming your wife was never infected with HBV, she would then be protected with the vaccine and you can certainly have unprotected sex at that time. You just want to be sure she was not infected previously. Regardless, there is no reason you cannot have another child. I would still encourage you to have any additional children receive the first shot of the vaccine before the leaving the hospital. They would then complete the vaccine series according to schedule.
      At this time there is no complete cure for HBV, even though your viral load is very low. 1-2% of those chronically infected will spontaneously clear their HBV infection annually (serconverting losing HBsAg and gaining the antibody), but of course this is a small percentage. I do see that your ALT (SGPT) is or has been elevated. I don’t know the timing and if it relates to losing HBe or if it is related to something else, so I would suggest that you speak with your doctor. A normal ALT for men is 30 IU/mL.

  55. I used Punarnava from Ramdev BABA Ayurvedic….
    there agter I got the difference that viral come down from 406 to 32 IU/ml

    HBeAg- Non Reactive-.29
    Anti HBc-Reactive-12.25
    Anti HBe-Reactive-.01

    • As I mentioned previously, it is normal for the virus levels to fluctuate. It’s impossible to know if it has anything to do with any ayuredic treatment you may have taken. I do not have study data on these treatments.

  56. Dear Dr Protzer,

    I have hepetieites B positive with almost of 16 years now and was considering my case as career and last 12 years i have done plenty of test with reuglare follow up each 6 months for LFT and yearly for HBV DNA by PCR including

    HBEAG negative
    HBEAB positive

    PCR for HVB DNA WAS 330 IU/ml IN 2006 ,751 IU/ml 2008 ,750 IU/ml 2009 , 850 IU/ml this was in july 2011 and i finally was 320 IU/ml .
    what is reasn of varition of HVB DNA
    LFT was normal sgot was 18 u/L 26TH MAY 2013
    AFP WAS 9.52 IU/ml 26TH MAY 2013

    Is there any treatment form my case as i have told that no need for tretment for timebeing

    Reagrds

    • It is good that you are being carefully monitored for your HBV by a liver specialist. It is completely normal for the viral level to fluctuate over time. Please don’t worry. They are still considered low and that treatment would not likely be recommended with such a virus level. When your doctor sees it creep up and continue to stay up then your doctor may be more concerned. Your SGPT is perfect with normal being <30 IU/mL for men and <19 IU/mL. Your AFP is below 10, so you should be good. Continue monitoring your AFP along with your other levels. The only time there is additional concern is if there is a family history of severe liver disease or liver cancer. I agree with your doctor, based on these results, that you do not need treatment at this time. As always, continue monitoring.

  57. hello,

    I have been reported with Gamma GT at 69 U/l
    HBV viral load – 1060 IU/ml or 3600 copies/ml by PCR test

    are these alarming levels? should i start a treatment or should i look for additional test to double check the existance of the virus.

  58. i am also HBe positive 0,08
    HBc IGM – negative

    • I am having trouble responding with the application but see you added your HBeAg status. I would encourage you to speak with your doctor, but a viral load of 1,060 Iu/mL is not alarming for someone with HBeAg positive HBV. However, see if you are HBeAb positive or negative and talk to your doctor about your ALT/AST

  59. Hellow sir,

    My viral Load was 406 IU/ml on Feb-13 and I had the same test on 14th june It was 32IU/ml. It was reduced a lot.
    My wife and 2 years daughter have negitive and done vaccinated successfully.
    1.Can I go for 2nd kid as my wife have vaccinated.. ?
    2.Can I cure completely because my viral load has reduced a lot.
    3.As on 17.12.12 SGPT-79 SGOT-48
    As on 6.1.13 SGPT-86.3 SGOT-37.7
    As on 22.4.13- SGPT- 59 SGOT-45
    I used Punarnava from Ramdev BABA Ayurvedic….
    there agter I got the difference that viral come down from 406 to 32 IU/ml

    HBeAg- Non Reactive-.29
    Anti HBc-Reactive-12.25
    Anti HBe-Reactive-.01
    Kindly Guide me sir

  60. Dear Sir,
    I have hepatitis B positive. I first notice that on 17/02/2013. I went to see Dr. then he ordered the hepatitise B panel blood test to know if i am Chronically infected. So i have done plenty of test: 01) ANTI HBC(IGM) – NEGATIVE
    02) ANTI HBC(TOTAL) – POSITIVE S/CUT OFF RATE:0.10
    03) ANTI HBE – POSITIVE
    04) HBE AG – NEGATIVE
    05) ANTI HBS(HBSAB) – 0.00 IU/L
    06) SGPT (ALT) 41 U/L

    My Dr. said that i am a chronic carrier and he started treatment with ”visud” twice a day for two month. After this medication my Dr. ordered more test to see how i am gettin on.

    Test: 01) HBSAG -( ELISA) – POSITIVE 02) HBEAG – NEGATIVE 03)ANTI HBE – POSITIVE 04)HBV-DNA (DETECTED) 1260 IU/ML 05) ALT(SGPT) – 60 UL ON 19/05/2013. MY ALT WAS 41 UL ON 20/02/2013.

    So after all the test my Dr. adviced me i could go for treatment with PEGINTERFERON ALFA-2A 180 mg for the 52 weeks. My query is to know that if i am a good candidate for this treatment if so then will i recover the virus?

    Tnank you for you help….

    • You have HBe negative HBV, though your viral load is not very high and not at the threshold normally considered for treatment with someone that is HBeAg neg. A normal ALT is 30 IU/mL for men and 19 IU/mL for women. Your level of 60 is double, which is certainly elevated, but it is also possible it is elevated for other reasons – food, drink and other medical conditions impact ALT. I think i would have a conversation with your doctor. He knows best about your overall health, family history, etc. , but it is good to have the conversation to see if the timing is right. You might like to track your ALT for a bit longer – while at the same time, be sure to avoid alcohol, eat a well balanced diet and get plenty of exercise. Do you have evidence of liver damage based on an ultrasound or biopsy? These are other things to consider. Please speak with your doctor.

  61. Hi, I’m HepB positive diagnosed 2 yrs ago. I had HBV DNA test this week and this is my result, 3,029,165 copies/ml. What does it mean? Please enlighten me. Thanks.

    • It’s important to evaluate your HBV DNA levels against other hepatitis B markers and liver function tests. For example, it makes a difference if you are HBeAg positive or negative and how your ALT (SGPT) and other liver function tests look. I would encourage you to speak with your liver specialist so he can lend insight into your HBV status and liver health.

  62. Mr Ganapati,

    Can the drud be got in NIgeria? Can I order it online…Please I need your respose. Besides, did u get yourself involved in any diet change while using the drug

  63. SIGNOROUS ANYIMAH

    I have been diagnosed to be chronic hepatitis B patient a year ago. Today 10th June, 2013, I took a profile and the results are as follows:
    HbsAg Positive
    HbsAb Negative
    HbeAg Negative
    HbeAb Positive
    HbcAb Negative

    Kindly advice me on my state. Never mind to be realistic with me in telling me the true state. I am psychological prepared for it.

    • No one wants to be diagnosed with a chronic illness, but think positively. Many with HBV live long, full lives with family, love, friends, work etc. I can’t tell you too much about your HBV. You are currently HBeAg negative, which is often good, but you will want to talk to your doctor to see if you can get a HBV DNA test done so you can learn your viral load. It is also important to have liver function tests run – especially ALT/AST. I encourage to get further evaluation from a liver specialist so he can sit down and discuss your results with you. Be sure those you love (sexual partners and close, household contacts ) are screened and vaccinated to protect against HBV . Make positive changes in your life and avoid the use of alcohol, smoking and eat a well balance diet and be sure to exercise. it’s important for your liver and your overall health.

  64. My wife is 23 years, we discovered that she is infected with virus B. She did the following test on January 2013:
    Hepatitis Marker Report
    1. HBC Igm ———— Negative
    2. HBC Ab ———– Positive
    3. HBE Ag ———— Negative
    4. HBE AB ————- Positive
    5. HBS AG ————- Positive – 2918
    Tumor Markers Report:
    AFP (Alfa – Fetoprotein) ——– 2.7 IU/ML
    Clinical Chemistry Report:
    ALT (SGPT), serum ———– 23 U/L
    AST (SGOT), serum ———– 18 U/L
    PCR Report:
    HBV – DNA by PCR Quantitative ——- Result below detection limit.

    The specialist recommend to repeat the last three tests every 6 or 12 months.
    She repeated them on July 15, 2013 and showed the following results:
    *S.G.O.T ( A.S.T ): 20 U/L
    *S.G.P.T ( A.L.T ): 18 U/L
    HBV DNA by Real Time PCR(Quantitative)
    Qualitative: Positive
    Quantitative:630 IU/ml

    Do these results refer to bad revolution of her status? Dose she need treatment? Can she transfer the virus to others?
    What is your opinion and recommendations?
    By the way, i have received 3 doses of the vaccination, and i did a test for the antibodies after the 2nd dose and showed > 1000 iu/ml.

    Thanks & regards

    • It looks like your wife has a chronic HBV infection and is in the inactive phase of the virus. This is a great place to be with her HBV. (She is HBeAg negative with the antibody and she has an undetectable viral load and normal liver function tests) I would agree with your doctor to repeat the liver function tests and the HBV DNA annually or semiannually. Your wife would not benefit from treatment at this time, so try not to worry. Monitoring and living a healthy lifestyle is very important. Be sure your wife avoid alcohol and smoking and maintains a healthy weight by maintaing a healthy diet.

      At this time your wife has no viral load so she will not transmit to others. However, a person’s HBV status can change which is why it is so important to continue with regular monitoring. That is why it is good for you or other close, household contacts to be vaccinated. Based on your titres, you generated adequate immunity so you are protected. You do not need to worry about getting HBV from your wife or any other situation with infected blood of body fluids. When you and your wife decide to have children, please be sure that your baby receives the first shot of the HBV vaccine series and a shot of HBIG within 12 hours of birth. This prophylaxis is effective 90-95% of the time. Your wife can discuss this with her doctor.

  65. Dear Doctor,
    Many thanks for you quick reply,really appreciated.
    If you don not mind, I have additional 3 inquiries:
    1-why the HBV DNA increased from below detection limit to 630 IU/ML? And does it mean it will increase continuously? Is this increase a bad sign for anything?
    2-what do u mean by viral load? And when can we say she has viral load?
    3-when can she transmit the virus to others? Does her ability to transfer it is a function in the HBV DNA?

    Many thanks in advance….

    • In general, viral loads will fluctuate, but often those with undetectable viral loads will remain that way for years. This does not necessarily represent a trend, but your doctor is carefully monitoring her. Should her viral load (HBV DNA) continue to climb, he will likely want to treat her. Treatment is considered at around 2,000 IU/mL or higher for those who are HBeAg negative, but there are other factors. When the viral load continues to elevate for those that are HBeAg negative, it indicates a mutation, which should then be treated. She might also see an elevation in her ALT should her viral load continue to elevate. Normal levels for women are 19 IU/mL. The viral load is the concentration of the virus in the blood. And you are correct, the higher the viral load, the more likely your wife is able to transmit the virus. Your vaccination will protect you regardless. It sounds like your wife has a excellent liver specialist who is carefully monitoring her.

  66. Dear doctor,
    Many thanks for ur reply.
    You mentioned in you first answer that my wife is in the inactive phase of the virus, is this becuase the HBE AG negative? If the answer yes, will the first 5 test that i mentioned in my first question change with time? If the answer is yes, should i repeat it to continously monitor them?

    Thanks & regards

  67. Hello Doctor,
    Can you please answer may last questions?

    Thank you in advance….

    • I didn’t number the answers, but did answer them:
      2. The viral load is the concentration of the virus in the blood. (amount of virus circulating)
      3. And you are correct, the higher the viral load, the more likely your wife is able to transmit the virus. (Transmission is via direct contact with infected blood and body fluids. once again, increase the viral load and the you increase the infectivity of the person)

  68. Doctor,
    My question is will the following test change with time?
    1. HBC Igm ———— Negative
    2. HBC Ab ———– Positive
    3. HBE Ag ———— Negative
    4. HBE AB ————- Positive
    5. HBS AG ————- Positive – 2918
    If the answer is yes, should I repeat them continuously?
    Also, which indicator will reflect that the status is changed from inactive to active phase?

    Thanks,
    Lee

    • The IgM and HBcAb do not need to be repeated. HBeAg/HBeAb tend to not change either, but occasionally they do. Unfortunately, HBsAg typically does not change, but 1-2% of those chronically infected will spontaneously seroconvert. Follow the recommendations of your liver specialist. By watching ALT/AST and other liver function tests, and HBV DNA, he may choose to re-run some of the HBV markers, and some of them are just part of a panel he may be interested in running. Obvious change is noted with ALT elevation and an order of magnitude or more change in HBV DNA.

  69. hello sir my hbv viral dna load test is shown :245,720 copies/ml
    is it dangerous what do you think at which phase i am am i carrier? plz rsvp

    • Being a carrier does not tell you anything about the infection. It merely indicates that you are HBsAg+, which means you have a current HBV infection. Your viral load is high, so you are likely HBeAg positive. You will want to talk to your doctor about having additional tests run. Are you acutely or chronically infected? Are your ALT or other liver function tests out of range? Are you HBeAg positive or negative? These are the sorts of tests you will want to have run and discuss with your doctor to learn more about your HBV and your liver health.

  70. Hi
    hbeag is 0.512
    hbv dna is 1041 iu/ml
    hbcab igm ab is23.82
    hev igm ab negative-0.24
    ast is 89
    alt is 79

    what is my condition on above based result

    • it’s important that you discuss any results with liver specialist. It appears that you are likely chronically infected. Do your know your viral load? You may want to talk to your doctor about getting this test if it is available to you. Your ALT/AST are elevated, but of course it can be elevated for reasons other than your HBV, but it does indicate your immune system may be responding to the infection. Talk to your doctor.

  71. Hi…
    Unable to understand ur views.
    Pls reply to my queries starts with sandy….
    Test dn on 14-6-13.
    HBsAg – possitive
    HBeAg – non reactive- 0.02
    HBcAb-IgM – reactive – 23.82
    HEV-IgM Ab – negative – 0.24
    LFT test dn on 05.07.13
    Total Bilubirin – 5.1mg/dl
    AST – 104 IU/L
    ALT – 101 IU/L
    Alubumin – 4.5 g/dl
    Globulin – 2.7 g/dl

    test dn on 08/7/13
    HBV DNA Quantification-1041 IU/ml
    HBeAg – non reactive – 0.512
    LFT results as on 11/7/13
    Total bilubirin -2.1
    AST – 80.2
    ALT – 97.2
    Albumin – 3.7
    Globulin – 2.9
    what is my condition now as per above test ?…
    Do test be repeated ?
    Do the viral load is very high ?
    Is is chronic or acute hepB ?

    • I’m not sure what you mean about “understanding ur views”. It appears that you have an acute hepatitis B infection since you are HBsAg positive and your HBcAb IgM is positive. You were also tested for hepatitis E and the result appears negative. You appear to be clearing your acute HBV infection. (90% of healthy adults who are infected with HBV will clear the infection within 6 months, on their own, without any need for medication). Your HBeAg is negative and your ALT/AST levels are elevated, though they are going down with time, another indication that you appear to be seroconverting and clearing the infection. Your viral load is not very high. You will want to run a hepatitis B panel at 4-6 months following your first test. Your goal is to clear the virus and your test results should be HBsAg negative, HBcAb positive, and HBsAb positive. If your results show that you are HBsAg positive after 6 months, then you will need to get additional testing. Right now it looks like your infection is new or acute. Please be sure you take precautions during this time. Be sure recent sexual partners have been screened for HBV. There is a 4-6 week window before a newly infected person will test positive.

  72. Hi sir….
    Thanks for your reply.
    I will go as advised by you.
    Few thing i want to ask …
    Do i need to take special meditation and exercise?
    What about my diet that will be best at present?

  73. My Hbv quantitative test result shows Viral Load: 1,092 IU/ml, what does it mean, weather i am suffering from hepatitis b or not ?

    • You have viral load, so you do have hepatitis B. You first need to determine if you have an acute, new infection or a chronic infection. A person is considered chronically infected if they test HBsAg positive for longer than 6 months. Please talk to your doctor to learn more about your HBV and your liver health.

  74. THere is no HBV specific diet. Be sure to avoid eating fast foods and processed foods. Focus on eating vegetables, fruits, whole grains and lean meats. Exercise is also good, just be sure not to over-do.

  75. Hi sir,
    I was diagnose with HBV when I was pregnant and I did all necessary test after the test my viral load was 162 IU/ml, Haemoglobin parameters was-12.9-13.7g/dl, Haematocrit-33.3-37 percent andWBCT total was 6500-7,500/cm. My twins were given heamoglobin and they have being vasinated and my husband. Pls what does this mean?

    • The prophylaxis to prevent transmission of HBV from an infected mother to her baby is the first shot of the HBV vaccine given within 12 hours of birth. If possible a shot of HBIG is also given to the baby. Your viral load is quite low so that is good. Please be sure you continue to have the babies vaccinated according to schedule so they are protected against getting HBV. You should test them at a year or 18 months to be sure they did not get HBV.

  76. Hi Sir,

    I have tested positive to hep B about 8 months ago..
    Detail results was as at 9 jan 2013 are as follows
    hep B surface antibody- positive-0.6mlU/ml
    hep B e Antigen— negative
    hep B e Antibody—positive
    hep B core IgM– negative
    hep B Core IgG– positive

    AST–42
    ALT–36
    Viral log=0
    hep B DNA– No detection of hep B DNA Virus…

    Please I need some clarification on this result…

    • It looks like you are trying to seroconvert and clear the infection. Your liver function tests are still elevated, but they may normalize after time. You did not show the lab result for HBsAg. Are you still HBsAg positive? if so then you are still infected. However, you have generated some anti-HBs antibody, but not above 10 IU/mL. Give yourself another month or 2 and retest and have a hepatitis B panel run that gives you HBsAg, HBcAb (total) and HBsAb to see if you are HBsAg positive or negative, and the other results in relation to each other. Be sure to talk to your liver specialist at that time about results

  77. Hi,
    Could you please help me understand my test results. Am I still in a carrier stage, and should there be any medication/precaution used in this stage.

    Age: 32
    Hepatitis B Envelope Antigen: Negative
    Hepatitis B Envelope Antibody: Positive
    ALT SGPT: 49 (July-2013), 35 (Jan-2012),
    AST SGOP: 22 (July-2013)
    Hepatitis B Viral Load Quantitative: 743 IU/ML (July-2013), 375 IU/ML (Jan-2012)

    • A carrier is merely someone that tests HBsAg positive, so this term is not helpful to for those trying to describe their HBV. Your viral load is not undetectable, but under the range that is typically treated for a person that is HBeAg negative. Your ALT is elevated. Normal ALT for men is 30 IU/mL and 19 IU/mL for women. ALT can be elevated for reasons other than HBV, so discuss with your doctor. Often diet and exercise changes will help, but once again speak with your doctor. Treatment algorithms are very helpful, but ultimately your liver specialist can better evaluate your HBV and liver health since he has all of your information.

  78. JHONANZ
    Unable to understand ur views..
    Can you help me my test result..i have tested reactive hepa b..
    My test result last July 10 2013..
    1.SPGT/ALT- h 133.0U/L
    2.Anti Hbe (CMIA) – 18.30 non- reactive
    3.HbeAg (CMIA) – 514.71-reactive
    4. Alphafetoprotien (ECLIA)-1.66 U/ml
    5Liver UTZ- normal level sonogram..
    6.HBV DNA- 14,308,208 copies/ml
    PLEASE SiR what does this mean.?

    • It looks as though you have HBeAg positive HBV. Those that are HBeAg positive tend have higher viral loads and are more infectious to others. Your ALT is elevated and it appears as though you may be in the clearance phase where your body is trying to fight the virus. The problem is how long does it take to seroconvert losing HBeAg and gaining the HBeAb antibody? During this process when your immune system recognizes the virus, and is trying to fight it, damage is occurring which is evidenced by the elevated ALT levels (normal for men 30 IU/mL and 19 IU/mL for women) When serconversion eventually happens, a person’s viral load tends to go down. This is the good, but how long it takes to get there is the problem because liver damage is occurring along the way. I would encourage you to see a liver specialist. During this time you also need to take precautions because your viral load is higher making you infectious to others. Be sure to avoid direct contact of infected blood and body fluids with others and be sure to practice safe sex. keep personal items such as razors, clippers and toothbrushes separate to you do not accidentally transmit HBV to close household contacts. Partners and close household members should be screened and if they do not have HBV, they should be protected by getting the HBV vaccine series.

  79. Alley SOlomon

    Dear Dr.
    I have a test for further blood test. Can u explain to me if i will go for medication and if my test are what level i have. Thank you very much heres my result Hbsag positive, hbv dnA is 2.00logIU/ml have indetermine viral load below the linear range of assay. My alpha fetoprotein is 3.0 ug/L. What is mean by alpha fetoprotien. My GGT is 183U/L what mean by GGT and ALT. ALT test is 51U/L

    • The AFP is a test used to screen for liver cancer. Everyone with chronic HBV should be screened for liver cancer. Your test is normal, and keep in mind it is just a marker and by itself does not diagnose liver cancer. It’s always best to post the upper limits of normal for your tests. However, your ALT is elevated. A normal ALT is 30 IU/mL for men and 19 IU/mL for woman. So your ALT is elevated, but it can be elevated both due to HBV and other causes. You do not mention if you are HBeAg positive or negative. The viral load is looked at based on your HBeAg status. I would encourage you to speak with your liver specialist about your elevated ALT and whether or not you would benefit from treatment at this time.

  80. HELLO DOCTOR, WIFE AND I DIAGNSOSED OF HBV POSITIVE,WORRIED OF REINFECTION, NEED YOUR HELP

    • Hello, if both you and your wife are HBV+ then you do not need to worry about infecting each other. You only need to worry about infecting close household contacts. Be sure to avoid direct contact and infected blood and body fluids with others. Be sure to avoid sharing personal items such as razors, toothbrushes, nail clippers, – anything that may have trace blood on them, with other members. Be sure to have close household contacts or immediate family tested for HBV. If they are not infected, encourage them to be vaccinated.

  81. Hi Doctor,

    Cigarette smoking can contribute to elevate the amount of the HBV viral load..?

    Thank you

    • I do not know if smoking will cause an elevation in the viral load. However, smoking is an independent risk factor for liver cancer. Those with chronic HBV are already at increased risk for liver cancer, so it would make sense to not smoke.

  82. Hi doctor. As per previous test result…
    Total bilubirin -2.1mg/dl
    indirest bilubirin -0.5
    direct bilubirin -1.6
    ast -80.2IU/l
    alt -97.2IU/l
    Viral load -1024 IU/ML
    Hbsag -possitive
    hbeag – no reactive

    Last lft test dn on 26 july2013
    total bilubrin – 1.2mg/dl
    direct bilubirin -0.30
    indirect bilubirin -0.80
    ast -25IU/L
    alt -20IU/L

    what is my present condition as per above lft test dn?
    What is d reason for increase in indirect bilubirin?
    Do i need to go for hbsag and other test now?

    • It’s good to see that your ALT levels have come down. Previously they were elevated (normal 30 IU/mL men, 19 IU/mL-women). Your bilirubin was also elevated, though it is best to show units and upper limits of normal ranges of the lab. I have no idea why they were previously elevated or and why they have normalized. I don’t know when or why your liver function tests were elevated. Even when your LFTs were elevated, your viral load was not particularly high. Continue monitoring with your liver specialist and hopefully you will not see additional elevation in your liver function tests. Talk to your doctor and continue monitoring of your liver functions, have an AFP test run and talk to your doctor about getting an ultrasound.

  83. First of all , great effort by the administrator. really we should appreciate ..
    sir/madam,
    My father is a Hepatities B Patient.From Last one year and six months he had taken HBV DNA Quantative test thrice through PCR it reports as follows
    HBV DNA Quantification—–150000 IU/ML in FEB-2012
    HBV DNA Quantification—-7500 IU/Ml in AUG-2012
    HBV DNA Quantification—–Below 20 IU/Ml in JAN-2013
    HBV DNA Quantification—–Below 20 IU/Ml in JUL-2013

    we regularly consulting our gastroentologist,she suggested prohep ,tenohep,indral 10 mg .he is also a diabetic., is there any wrong ? what is the normal value of HBV DNA Quantification for men? please answer…
    Thanq in advance.

    • Thank you for your kind words. It seems that your father is getting very good care from his hepatologist. He is currently on tenohep which is an antiviral with tenofovir as the active compound. That is why he currently has an undetectable viral load. This is very good. There is no “normal” with a viral load, but the goal is to have an undetectable viral load if you have HBV. Prohep is a supplement for the liver. HBF does not endorse supplements, but it shouldn’t hurt him, and your doctor wishes for him to take it.. I’m not sure if you meant inderal? Your father is a little more complicated because of his diabetes. Please encourage him to take care with his diet and try to get regular exercise. Be sure your father is being screened for liver cancer biannually – AFP testing and ultrasound. Take care

  84. jay prakash verma

    Hi Sir can posible
    HBsAg Positive
    HbeAg Negative
    HBsAb Positive
    HBc Total Positive

    • I would encourage you to see a liver specialist for additional testing. At this time you have both HBsAg and HBsAb positive, Wait a couple of months and repeat the test with your liver specialist. You will also want to have an HBV DNA test run to see if you have a viral load, along with having the doctor check your liver function tests such as ALT, etc.

  85. Hi I just want to know about hep b test.in every laboratory it dose right way or not my blood test name :HBV viral load,HBeAg andAnti-HBe .thx a lot

    • The HBV DNA or viral load test is a PCR test. This test will take longer than your other labs though the time will vary with different labs.

  86. Hi,

    Just one question.

    If HBs Ag positive alone, negative for others, does it need to be treated or what is the management plan for this patient?

    Thank you.

    • Not sure what “the others” include. If you learn you have chronic HBV, (if you test HBsAg+ for more than 6 months then you are considered chronically infected), then you will want to be evaluated by a liver specialist to determine if you would be a good candidate for treatment.

  87. Hi sir/ madam,

    My question is… I am HBeAg (5.70) positive, and i want to know if what stage now?
    what would i do to cure?
    Thank you……

    • You are HBeAg positive, but without additional information I cannot tell you what stage you are in. It could be immune tolerant or immune clearance. I just published a blog on the different stages of HBV. Take a look, but I encourage you to speak with your liver specialist to learn more about your HBV and liver health.

  88. Hi,

    Today i collected my PCR report with 173 IU/ml Viral Load.
    My HbsAg screening was +.

    Please reply what should i do?

    Thanks

    Addam

    • Talk to your doctor to learn more about your HBV and liver health. At this time your viral load is very low so it is very unlikely you would be treated at this time, but you want to be sure to have your doctor look at the entire picture – personal and family health history, liver function tests, ultrasound, HBeAg/HBeAb and once they are reviewed, ask your liver specialist how often you should be monitored. Be sure to make healthy lifestyle choices. – Avoid alcohol, avoid smoking and maintain a healthy weight by eating a well balanced diet and getting regular exercise

  89. Sridharamoorthy

    Sir, My wife ANNAPOORANI is a two time KIDNEY TRANSPLANT patient. II transplant was done on29th Dec 1999. My wife was tested for HBV DNA Quantitative test and the result was 8093775 copies/ml. Dated 23/07/2013. what is this mean. I am living in the southern part of India. Kindly Guideme

    • Hello. I responded to your email. I would have her nephrologist (kidney specialist) consult with her liver specialist. Her viral load is quite high and I believe she will need to go on antivirals since the medication she takes for her kidneys is causing the viral load to elevate. Most likely she would be put on an antiviral. Please discuss with both of her specialists.

  90. Umar Mutakabbir

    HBV Test result
    HBsAg Reactive
    HBsAb Non-Reactive
    HBeAb Non-Reactive
    HBeAb Non-Reactive
    HBcAb Reactive
    Liver Function Test
    SGOT (AST) 37
    SGPT (ALT) 67
    ALKALINE PHOSPHATASE 261
    GAMMA GT 63
    BILIRUBIN TOTAL 0.23
    BULIRUBIN DIRECT 0.14
    BILIRUBIN INDIRECT 0.09
    TOTAL PROTEIN 58
    ALBUMIN 46
    GLOBULIN 12
    1. After six months of observation my Doctor says i should live normal devoid of alchol and smoking which i do not even do.
    i. Please can marry without any problem.
    ii. What is my future implication of situation.
    iii. Please educate me more of the results above and the way forward.

    • I believe I responded to your profile through an email you sent to info@hepb.org. You may be in the process of seroconverting since your HBeAg is negative but your HBeAb is also negative and your ALT is elevated. You will need to go back to your liver doctor in a few months to repeat tests. If you find you are in the immune clearance phase with your ALT still elevated and your HBeAb not changed to positive, then you may benefit from treatment. You might want to talk to your doctor about also having an HBV DNA test run.

  91. Please here is my first test result;
    HBsAg:positive
    HBsAb:negative
    HBeAg:negative
    HBeAb:positive
    HBcAb:positive

    After being on treatment for some months, my result has changed to become;
    HBsAg:reactive,
    HBsAb:Non-Reactive,
    HBeAg:negative,
    HBeAb:Negative,
    HBcAb:Negative.

    Please what can you tell me about this new result?

    • Originally you were HBeAg negative and HBeAb positive, but it looks like that was not a durable response since you are no longer HBeAb positive. (positive and reactive are the same, and negative and non-reactive are the same). Talk to your doctor about having your HBV DNA viral load checked. A good indicator of liver health are the liver function tests – particularly ALT (SGPT). You note that you were on treatment for some months. What are you being prescribed? I would encourage yo to speak with your liver specialist to learn more about your HBV and liver health.

  92. HI SIR,
    My test result are as follows,
    Hbe Ag. Non reactive
    Anti HBE. Reactive
    Liver Function Test. Normal
    ALT/SGPT. 43
    AST/SGOT. 20
    HBV DNA quantitative test. < 29 IU/ml
    that means good or not?Do I need treatment?

    • You appear to be in the inactive phase of the virus since you are HBeAg negative, anti-HBe positive and you have a very low/undetectable HBV DNA level. However, your ALT is a bit high according to standards noting normal as being 30 IU/mL for men and 19 IU/mL for women. Talk to your doctor about your liver and general health. It may be that you would benefit from simple lifestyle changes including exercise and ensuring that you eat a healthy, well balanced diet. Please be sure you avoid alcohol and smoking.

  93. Please my husband have the following report; HBV DNA copies
    4886449 cp/ml
    hepatitis b virus DNA : 839596 IU/ml , s- alpa fetoprotein: 10.3 KU /l , HbcAb : positive , HbcIgM : negative, HbsAg : positive, HbsAg core value : 614.82 IU/ml , HbsAb:negative and its value 0.00 miu/ml , HbeAg : negative, HbeAb : positive. Please what is the interpretation of this report

    • I would encourage your husband to talk to his liver specialist about his results. He is currently HBeAg negative and anti-HBe positive, but his viral load is quite elevated. It appears that he has HBe negative HBV caused by a mutation. This is not uncommon, but should be addressed. Be sure he has his ALT and other liver function tests checked. Normal for men is 30 IU/mL. Have him talk to his doctor about what is best at this time.

  94. I am hepatitis B patient.
    At 2007 -> ALT-N, HBeAG- Negative, DNA Negative, USG& EGD- Normal
    At 2010 -> HBV DNA-107 IU, S. ALT-48, HBeAg- Negative,,eAB Positive,
    TP with AGR-Normal
    At 2011 -> HBV DNA – 1251 IU, ALT -37
    At 2013 -> HBV DNA – 86764 copies/ml, ALT 63, FIBRO SCAN- FSS-4.3/ NO VX/NEG
    Above my health condition, My doctor told me my liver is fine but hbv
    dna increasing now he give a tablet Entecavir(.5) at night time.
    Please tell me what is my condition.. Why my hbv dna increase day by
    day

    • It appears that you have HBe negative hepatitis B. This is not uncommon and may happen after along inactive period. It is good that your doctor has put you on entecacvir. This is a very good antiviral, and your viral load should start going down. However, please be sure you continue to take entecavir as directed and do not stop without the advice of your doctor. Abruptly stopping an antiviral can result in flares that can damage your liver.

  95. Hi! I am really glad i found this page. I just had my hbv dna result. I had 25 IU/mL last 2011 but now the result is:

    485 IU/mL
    HBeAG non reactive
    SGPT/ALT 41 U/L
    Liver ultrasound : mild fatty liver

    Am i a candidate for treatment?

    • Welcome to the blog At this time, it is unlikely you would be treated because you are HBeAg non reactive and your HBV DNA level is below 2,000 IU/mL. I would encourage you to continue bi-annual monitoring of your viral load and liver enzymes by your liver specialist. Your ALT is a bit elevated at 41 IU/mL. A normal ALT for men is 30IU/mL or less. However, since you have mild fatty liver, it is very possible your elevation may be due to the NAFLD. You might consider looking at your lifestyle to see if you can make any dietary changes or add regular exercise to your routine. It would be nice to see the ALT go down after making these changes. Your doctor might choose to look at your ALT more regularly to see if the diet and exercise changes help lower the ALT. Talk to your liver specialist.

  96. Thank your for replying. Actually, I had a test before this ALT test. it was at 80. I did a change of diet and it went down to 41. I am still on a diet. And I don’t plan to go back on the kind of diet I had before. Fatty and tasty foods. Thank you again. I am lucky to find your blog.

  97. Hi All. I am a 27 years old Indian male. I live in Glasgow, U.K. and like most of us present in this community, I am praying and hoping for a cure for Chronic Hep B in near future.

    I am new to this community. So please bear with my naivety.
    I was diagnosed with Chronic Hep-B 3 years ago. Following are few details from the subsequent tests done 3 years ago:

    Chronic HBV Infection genotype D
    Hep B Surface antigen – Positive
    Hep B e Antigen – Positive
    Hep B e Antibody – Negative
    Hep B Core IgM Antibody – Negative
    Hep B core Antibody – Equivocal
    Hep B core Antibody – Positive
    Chronic Liver Screen – Negative

    HBV DNA: 3179743794 copies/ml; HBV log(ref): 9.5
    Fibroscan: 5.6kpa (Doctor’s comment – No evidence of fibrosis)
    Abdominal Ultrasound: Normal.

    At that time, the liver specialist informed me that I am in immune tolerant phase and treatment is not required. However, as advised, I have been carrying out LFTs pretty much every 3-4 months. The ALT/AST levels have been normal except for two borderline flares in last 3 years. The most recent flare (2 months ago) was ALT: 65 with normal AST level. As I have recently moved to a new place, my new G.P. has referred me to a Liver Specialist. I have an appointment with Liver specialist in a month’s time.

    After reading few posts on this community, I understand that it’s normal to have such a high HBV DNA in immune tolerant phase with normal LFTs. As you would expect, stress and anxiety have overwhelmed me for last couple of years. I often wonder about future prognosis of my condition and it’s affect on my young family.

    I also understand that treatment is not recommended in immune tolerant phase under current medical guidelines for various reasons. Please advise about the questions I should be asking during my visit to the liver specialist. Any comments or few words of support and encouragement are welcome. Many thanks.

    S.

    • Hello, this is not actually a forum, but rather a blog where the questions are answered by one person. Please feel free to read through the blogs. I hope it will help bring you up to speed about your HBV. Be sure to visit the HBF’s very comprehensive website at http://www.hepb.org/index.html .If you are looking for an information and support group, I would highly recommend the HB list, which is a private list serve. You can join this group at http://hblist.net They are a wonderful group – very experienced and very supportive. Please consider joining.

      I don’t know if I would consider you in the immune tolerant phase. I would disagree that your ALT is normal since the normal range for men is 30 IU/mL and 19 IU/mL for women. I agree that you really need to be evaluated by a liver specialist. There isn’t one formula for treatment recommendations and of course ALT may be elevated for other reasons. Please consider your lifestyle and see if a change in diet and exercise affects your ALT. Definitely get the evaluation by a liver specialist.

  98. Sawayfa Muhammed

    Hello,

    16.10.2012: 3.14E+02 copies/mL

    30.07.2013: 2.27E+03 copies/mL 6.67E+02 method: **real time pcr -abbott(0.2ml)

    what does that indicate?

    • You did have a one fold increase in the HBV DNA viral load in a year, so you want to be sure you continue monitoring with the liver specialist. However the viral load does fluctuate over time and may cycle up and down. Your results are in copies per mil liter and not IU/mL, so you may wish to ask your doctor about the exact conversion used by the lab. Talk to your doctor to learn if you are HBeAg positive or negative and whether or not your ALT or SGPT is within normal limits (30 IU/mL for men, 19 IU/mL for women). Once again continue monitoring and be sure you are taking care of your liver health by making healthy lifestyle choices.

  99. Hi!

    I’ve been into medical examination just last week and that was my first time having that one. It was resulted that my HBsAg is reactive and the rest are negative what will be the possible outcome with that? Am I infected with the virus?

    • Since you are HBsAg positive, it means that you currently have a hepatitis B infection. When you say all of the rest are negative, I’m not sure which tests you mean. It’s not clear if you have a chronic or an acute infection, but if you continue to test HBsAg+ after 6 months, then you are considered chronically infected. If that is the case, it would be best if you go to a liver specialist so you can learn more about your hepatitis B infection and your liver health. Please take precautions while you wait and learn more about your HBV and take good care of your liver health by avoiding alcohol and smoking, and eating a well balanced diet.

  100. sir,
    my sgpt is 51, hbe antibody is -reactive, hepbe antigen is non reactive, viral load is 3670. plz suggest me what step should be taken by me at this stage.

    • I would encourage you to speak with a liver specialist about your HBV and liver health. You are currently HBeAg negative, HBeAb positive, which is often a less active or even inactive stage of the virus, but at this time your viral load is elevated above 2,000 IU/mL (though you do not give units, I am assuming it is IU/mL?? Please discuss this with your doctor), so it is possible you have developed a mutation and that the virus is once again active. Normal levels for SGPT are 30 IU/mL for men and 19 IU/mL for women, so it appears yours is elevated. SGPT may be elevated for reasons other than HBV (weight, diet, exercise, etc.), but this should be looked at with your liver specialist. He will likely repeat labs once or twice over the next 6 months and decide if you are a good candidate for treatment.

  101. Sir 2 months ago… I had hbsag positive .. and my hbv dna tests were non reactive. .. but recently I perform ed the hbsag tests again from 3 different pathological centres and it turned out non reactive every time… wat does it mean…??? am I still having the virus inside me… can it be transmitted to my wife from me…. please help..

    • This sounds like very good news! Most likely you had an acute or new HBV infection and your body was able to get rid of it. 90% of healthy adults that are newly infected with HBV will clear the virus on their own. I would encourage you to have one more test, but this time get a hepatitis B panel. This is one blood test that tests for HBsAg, HBcAb and HBsAb. This is helpful because it will tell you if you generated immunity to HBV (positive HBsAb). Anyway, it sounds like you have cleared the virus and would no longer be infectious to your wife or others. However, I would encourage you to have your wife tested so she can see if she got HBV while you were infected and infectious.

  102. i got these results, what do they mean? and what is the next step to take? am i a candidate for treatment? am i a possible threat to the community around me?

    hep b surface antigen- positive
    hep b virus dna-13,049 copies/mL
    antibody to hep b surface antigen- non reactive
    hep b virus e antigen- non reactive.

    • I would encourage you to talk to a liver specialist about your HBV. Your HBV DNA levels are elevated at 13,049 cp/ml, though at this time you may be in clearance mode with your body trying to seroconvert and lose HBeAg and gain the antibody. Your liver specialist will want to repeat labs in a few months to see what happens. If you do seroconvert and lose HBeAg and gain the antibody, your HBV DNA will likely go down. You don’t say anything about your SGPT or ALT. Normal levels for men are 30 IU/mL and 19 IU/mL for women.

  103. un vuaj nga nje hepatiti B HbSAg kam dy muaj me kete semundje, dhe kam nje temperatur 37.5% qe nuk me ulet akoma ,,kam dhe dhimbje trupi duke filluar nga kembet pastaj me kalon ne krahe e me radh,, nuk kam filluar kurimin per shkak te analizave qe me jan kerkuar qe duan koh ,,ju lutem a ka sherim kjo semundje ???

    • Unë jam duke përdorur google translate. A e dini se në qoftë se ju keni një akute ose kronike hepatitit B infeksionit? Ju do të duan për të konfirmuar këtë me mjekun tuaj. Në qoftë se kjo është një e re, infeksion akut, 90% e të rriturve të shëndoshë do të pastrojë virusin të tyre pa nevojë për mjekim. Në qoftë se kjo është një infeksion kronik (Nëse ju test HBsAg për më shumë se 6 muaj, atëherë ju keni një infeksion kronik), atëherë nuk ka asnjë kurë të plotë, por ju mund të bisedoni me një specialst mëlçisë rreth tretmaneve në dispozicion dhe nëse ju do të jetë një kandidat i mirë për trajtim. Ju lutemi të jetë i sigurt për të marrë kujdesin e mëlçisë tuaj gjatë kësaj kohe. Mos pini duhan dhe të përpiqemi për të ngrënë një të shëndetshëm, dietë të mirë-ekuilibruar. Pini shumë ujë të pastër. Ju lutemi të marrin masa paraprake për të shmangur transmetimin HBV për të tjerët. HBV është përhapur përmes kontaktit të drejtpërdrejtë me gjak të infektuar dhe lëngjeve dhe kjo është gjithashtu një sëmundje seksualisht të transmetueshme.

  104. HBV-DNA(Quantitative)PCR – 5500 IU/ml
    Hep B core antibody Reactive
    Hep B envelope antibody Reactive
    Hep B core antibody -IgM Non-reactive
    Hep B surface antibody Non-reactive
    Hep B surface antigen Reactive
    Hep B envelope antigen Non-Reactive

    LFT – Normal

    Do I need to go on a treatment ?……If yes then how successful is the treatment?..And once treated will it relapse

    Thanks in advance

    • I would encourage you to speak with your liver specialist about your HBV and liver health. You say your LFTs are normal, but please note that normal ALTs (SGPT) are 30 IU/mL for men and 19 IU/mL for women. You are HBeAg negative, and your HBV DNA is in a range where treatment would be considered. Talk to your doctor about your treatment options. At this time, there is no complete cure for HBV. If you decide to take an antiviral, you will most likely take them for years or even for life. The antivirals control the virus by stopping replication, so if you stop taking them, there is a good chance the virus will rebound and cause a liver flare resulting in liver damage. This is a discussion you want to have with your liver doctor. The antivirals with the best resistance profiles at this time are tenofovir and entecavir.

  105. heloo realy apreciate ur work….i have my pcr report for hbv its 1456 copies/ml…..anti hbeag positive with ALT2 times above normal…..am i a candidate of antiviral treatment??my age is 25

    • It is important that you discuss your results with your liver specialist. your HBV DNA viral load would not necessarily indicate you need treatment at this time, though your ALT are elevated. Normal levels for men are 30 IU/mL for men and 19 IU/mL for women. There can be other reasons for ALT elevations – many of these reasons are lifestyle dependent. Consider your lifestyle. If you drink alcohol – stop. If you smoke – stop. Consider your weight and the amount of exercise you get regularly. Discuss this with your doctor. Your doctor may wish to repeat testing over the next 6 months or so. The guidelines for treatment are merely that – guidelines and recommendations. Only your doctor has the complete picture. Talk to him

  106. HBsplease here is my first test
    HBsAg-positive
    HBsAb-negative
    HBeAg-negative
    HBeAb-positive
    HBcAb-positive
    l also had the liver function test as follows
    Total protein-57.2
    Albumin-34.0
    Total bilirubin-35.1
    Direct bilirubin0.3
    Indirect bilirubin35.4
    GT 26.7
    Alkaline phos 150.6
    AST 55.2
    AlT 44.4
    please what should l do?
    Am 25years old can l procreate without bringingforfh infected babies?
    what treatment do l need?
    PLEASE HELP ME OUT.THANK YOU.

    • I suggest you talk to your liver specialist about your HBV. You do not mention your HBV viral load, which is another important factor in determining if treatment is needed. AT this time your ALTs are elevated since the normal is 30 IU/mL for men and 19 IU/mL for women. However, ALTs can be elevated for other reasons too. you want to have this discussion with your doctor. You are young and it is good you are being carefully evaluated. There is no reason you should not be able to procreate because of your HBV. Please be sure your sexual partners have been vaccinated to protect them from getting hepatitis B. If not you must have protected sex. When you have found someone you wish to have a child with, please be sure she is vaccinated. HBV is very effectively passed from an HBV infected woman to her baby so it is very important that the future mother of your children has been vaccinated. when your children are born, they should also be vaccinated to protect them. In general, HBV is transmitted through direct contact with infected blood and body fluids. Vaccination is best, but avoiding direct blood-to-blood contact is another way to protect against HBV transmission. Please talk to your liver specialist.

  107. Sir I am hapatius b carrier my alt is 78. HBA Quantitative pcr shows 674,898 IU/Ml viral load. I am diabetic type 2 patient also and taking diabetic medicine. i m 37 year old. what treatment i have to take.

    • It is very important you speak with your liver specialist about treatment for your HBV. At this time your HBV DNA is high and your ALT is also elevated. A normal ALT is 30 IU/mL for men and 19 IU/mL for women. You have the added complication of diabetes so it is important that you address both your HBV and diabetes. At this time, the antivirals with the best resistance profiles are tenofovir and entecavir. I would discuss taking one of these antivirals with your liver specialist. Please be sure to consider lifestyle changes that will benefit both your diabetes and your liver health. Strictly following a diet for your diabetes will be very helpful. Be sure to avoid alcohol and smoking. Add regular exercise to your routine.

  108. Hey could you please tell me what this means
    HBSAG positive
    HBSAG value 797.30IU/ML
    Hbsab negative
    Hbsab value 0.0mIU/mL
    Hbeag negative
    Hbeab positive
    Hcv negative

    • You have hepatitis B, and you do not have hepatitis C. First you will want to learn if you have an acute or chronic case of HBV. If you test HBsAg+ for longer than 6 months then you are considered chronic. If you learn you are chronic, please see a liver specialist for a thorough evaluation. While you wait to learn about your HBV, be good to your liver by avoiding alcohol, smoking and be sure to eat a healthy, well balanced diet. Be sure to prevent transmission to others. HBV is spread through direct blood to blood contact and sexually. Be sure partners are vaccinated, or you are practicing safe sex.

  109. Sir I am a man of 47 years old ,
    I didn’t do any hapatius b test before, my first test (days ago) shows that : HBs Ag + , sgot=24 , sgpt = 24
    HBA Quantitative pcr shows 76 IU/Ml viral load.
    do I need treatement or I have to wait maybe my body will get rid of the virus since the viral load is low , and what treatement is needed ?

    • Please be sure you are seen regularly by your liver specialist so your HBV and liver health and can be evaluated over time. Right now your liver function tests you note above are normal and your HBV DNA viral load is very low. It is very unlikely treatment would be considered at this time, but you really want to have this conversation with your doctor. Since you are a man and over 40, you will want to talk to your liver specialist about biannual or at least annual liver cancer surveillance with an AFP blood test and an ultrasound.

  110. Dearest sir,iam a carrier of hepititas b virus ,unfortunately due to maltreatment of fever by doctors i got jaundicein feb 2013 ,although i have recovered but i have alot of trouble with my stomach .My ALt is 62 whereas ideally it should be 7 to 42 . some three days back i had my elisa test of Hbsag,which showed cut of value 1 and patient value 35920.5 please help me in this regards about the patient value .It should be noted My Pcr for Dna was negative some 2 years back .

    • I am sorry to hear that you have not been well. You will want to work with your liver specialist to learn if you are experiencing flares which make you sick or if you are jaundiced or experiencing symptoms due to something else. Your ALT is elevated. A normal ALT for men is 30 IU/mL or less. Now this elevation can also be caused by other problems unrelated to HBV, but it certainly may be a result of something you are experiencing because of your HBV. you will really need to work closely with your liver specialist to determine the cause. So it looks like you had a quantitative HBsAg test rather than a HBV DNA viral test? Do you know what your PCR is at this time? The quantitative HBsAg test is not particularly helpful at this time, but may be helpful to measure the response to treatment. Perhaps you are undergoing treatment…? I would encourage you to get another viral load test run (PCR) and see if it is still undetectable. it is possible that it is not and may be causing you some problems. Please speak with your doctor.

  111. Aditya Kumar Behera

    I’m 28 years old man.
    During my medical tests at GAMCA, I was reported HBsAG+.
    The tests from a reputed laboratory has the following results.
    SGOT : 24
    SGPT : 32
    HBeAG : 0.46 (NON-REACTIVE)
    HBcAG : 16.290 (REACTIVE)
    HBV DNA Quantitative : 281 IU/ML
    What does these results signify? I need to pass the medical test i.e. have negative HBsAG to go to middle east for job appointment. Please reply.

    • It appears that you are likely in the inactive phase of hepatitis B since you are HBsAg+, HBeAg negative, and have a low, but detectable HBV DNA and very slightly elevated ALT (SGPT – normal is 30 IU/mL for men). Unfortunately there is no treatment or way to change your HBsAg positive lab to an HBsAg negative value. That is one reason we say there is no complete cure for chronic hepatitis B. Occasionally someone chronically infected wiil spontaneously seroconvert and lose HBsAg and gain the antibody, but it is not common – only 1-2 % per year of those chronically infected. I am sorry to tell you this and I am very sorry that your chronic HBV might keep you from employment opportunities. It is very unfair.

  112. Hello, what does the cut off and patient value means my HbsAg is + cut of value 1 and patient value 3295.2 ? please make a clear idea of patient value does it tell the virus load?

    • A quantitative HBsAg does not tell you the amount of virus in your blood. You need to have an HBV DNA test,(AKA viral load test, PCR) THis is also a quantitative test that will give you results in IU/mL or cp/mLt. A quantitative HBsAg test is not usually run in the US for diagnostic purposes, but rather may be used to track treatment response.

  113. Thanks for your kind response as per your advise i went to medical specialist i have been to medical specialist and he asked me to have series of Tests including HBV pcr for DNA quantitative ,Hbsab ,utlra sound and LFT again, complete reports are yet to come in few days ,surprisingly my ALT has gone down to 25 ul/ml from 62 Ul/ml with in one week ( as i mentioned you before my Alt is 62 ul/ml) .My ultra sound reports are normal as well,and liver has been seen perfectly alright in shape. My question is that is it good or bad that Alt has been reduced to 37 values with in one week? I am sorry i will only visit the doctor again when my complete reports will be coming which will take few days that is why iam bothering you.

  114. LTF report week before
    ALT 62
    BILIRUBIN 18
    ALKALINE PHOSPATE 267

    LFT REPORT ON 30-9-2013
    ALT 25
    BILIRUBIN 14
    ALKALINE PHOSPATE 180

    THESE ARE MY LFT REPORTS While the the other tests like PCR quantitative for HBV DNA and HBsab or HbeAB are yet to come in few days

  115. hi,

    I have taken the following tests and their resuls
    1. Virology

    HBsag – positive

    2. Biochemistry

    Test name Result Unit Ref range
    SGOT
    Ast
    24 UL less than 38

    SGPT
    Alt
    24 UL less than 41

    Gamma GT 22 UL 8 – 61
    Albumin 4.7 UL 3.4 – 4.8

    Hepatitis B virus DNAQuantitative PCR 418 IU/ML

    3. Ultra sound scan of Liver is shows normal homogenous parenchymal echopattern
    no intra hepatic biliary duct dilatation. portal vein and cbd are normal in course and caliber.

    4.hepatitis Be antibody:anti HBe(cmia)
    index value 0.02 (>1.00)

    5. Hepatitis Be ANTIGEN HBeag CMIA
    index value .25

    can i be completely be cured and would this virus ever go out from my system?
    await your feedback.
    regards

    • If you have a chronic HBV infection (if you have tested HBsAg+ for more than 6 months), then it is unlikely you will spontaneously seroconvert, though it does happen in 1-2% of those chronically infected per year. Confirm with your liver specialist, but you appear to be in pretty good shape with normal ALTs and a low HBV DNA level. Be sure to continue with regular monitoring and follow the advice of your liver specialist. Don’t forget to take good care of your liver health by avoiding alcohol and smoking, and be sure to maintain a healthy weight by eating a well balanced diet.

  116. hello i was diagnosed with hbv chronic in 2009, i was hbeg negative and still my hbeag antibody is positive. Every yr i have taken hbv quantitative pcr whose results are as follow:
    2009 : 5 iu/ml
    2010: 948 iu/ml
    2011: 100 iu/ml
    2012: 1496 iu/ml
    2013: 0 undetecable viral load, ! Alt: 95
    Can u tell me how is my condition and what do you suggest on basis of above results?

    • Interesting. I’m not sure. Your HBV DNA appeared to be trending up every year, so it’s a bit surprising to see it at an undetectable level at this time. Your ALT is quite high, though I’m not sure if that is all due to your HBV or some of it is a result of your lifestyle. I would wait a few months and retest to see if you ALT comes down a bit. If it starts to normalize I would consider re-testing your viral load. Did they check HBsAg/HBsAb, too? I would encourage you to speak to your liver specialist about additional testing. You might not wish to wait a year to see what is going on. If your ALT is not normalizing, you want to talk to your doctor to see what is the cause of the elevation.

  117. hello, just want to ask wheter i am reactive to hbv these are my lab results:
    hbsag: .023
    anti hcv: .030

    • The test will have a range. Please check the lab results. I’m not sure why they expressed them quantitatively rather than qualitatively – such as reactive/non-reactive or positive/negative.

  118. good day,my lab test last 2010 are this:

    SGPT/ALT——————- 14.54 U/L
    HEPATOBILIARY—————– normal ultrasound of the liver, gallbladder & pancreas.

    HBsAG w/Titer (ECLIA) 1796.000 REACTIVE

    Anti HBs (ECLIA) <2.00 IU/L NONREACTIVE
    HBeAg (ECLIA) 0.118 NONREACTIVE
    Anti HBe (ECLIA) 0.005 REACTIVE
    Anti HBc IgM (ECLIA) 0.072 NONREACTIVE
    Anti HBC IgG (ECLIA) 0.004 REACTIVE

    any possibilities of my system to get rid the virus??
    the doctors' remark or recommendation was, NO TREATMENT REQUIRED….

    thanks more power………

    • It appears that you have a chronic hepatitis B infection (Anti-HBc IgM negative, anti-HBc IgG positive). Since it is a chronic infection, I would encourage you to see a liver specialist. It would be helpful to learn what your HBV DNA levels are. A liver specialist may wish to repeat this series of test and monitor you a little longer before making a decision about treatment. Other variables such as age, family history, other liver function tests. etc are also important. Since you have a chronic infection, it is unlikely that it will be “cured” – meaning you will become HBsAg negative, HBsAb positive with an undetectable HBV DNA level. Please know that regular monitoring of HBV is very important.

  119. I am taking Viread and my HBV DNA is now undetectable. Does that mean the virus is now not active if my liver panel is normal ? Does the drug work to block the active replication process in the liver?

    • Yes. the antiviral works by suppressing replication of the virus in the liver cells. This is why it is so important to take the medication as prescribed. If you stop taking the medication, the virus will once again begin replicating, and there is the danger of a flare causing damage to your liver. Talk to your liver specialist if you have additional questions.

  120. I am 27 and a female; my test shows
    HBsAg Reactive
    HBsAB Non Reactive
    HBeAg Non Reactive
    HBeAb Reactive
    HBcAb Reactive
    ALT 41
    DNA virus is 234 IU/mL
    DNA copies 1362 cp/mL
    my question is am I at the acute or chronic stage?
    what does my DNA tell me?

    • I can’t really say for sure if you have an acute or chronic infection. If you have tested HBsAg positive for more than 6 months, or if you are anti-HBc IgM positive, then you are likely acutely infected, negative and you would likely be chronically infected. Your HBV DNA levels are quite low. Your ALT of 47 is elevated. A normal ALT for a woman is 19 IU/mL. However, ALT can also be elevated for other reasons – diet, cholesterol etc. Anyway, consider whether or not you have previously been screened for HBV and if it has been 6 months or greater. I encourage you to talk to your doctor and repeat testing. If you learn you are chronically infected be sure you are seen by a liver specialist to evaluate and monitor you HBV and liver health

  121. Hi, I just received the result of my test which confirmed that O am still hbv carier. Could you pls explain this result to me and sugest the kind of food to eat to keep my liver health.
    Serology indicate I have seroconverted and is now HBeAg negative, HbeAb positive with low titre HBV DNA 285 iu/ml. AFP is negative, LFTs normal and cryoglobulin negative (tested for the indication ofurticaria).

    • It looks like you are in an inactive phase of the virus where you are HBeAg negative, HBeAb positive and have a low HBV DNA level, along with normal LFTs (remember normal ALT for men is 30 IU/mL for men and 19 IU/mL for women). This is a very good place to be and does not require treatment. However regular followup monitoring with your liver specialist is important to be sure there are no changes with your HBV or liver health.

      Although there is no HBV specific diet, a healthy, well balanced diet is very important, along with regular exercise. Eat a diet full of vegetables, fruits, whole grains and limited lean meats. Be sure to avoid fast food (McDonalds, KFC etc), processed foods and pre-prepared foods. It is also best to avoid refined sugars. Drink plenty of good, clean water and always avoid alcohol.

  122. Greetings to you doctor iam here again with with my PCR Quantitative Report it says Hepititas B PCR for DNA( Quantitative ) Not Detected .. By real time PCR.

    All liver tests are fine but again the problem is my HBsAg comes to be positive :(

  123. am 27 and a male; my test shows
    HBsAg positive
    HBeAb positive
    anti hbe negative
    SGOT/SGPT -60/90
    HBVDNA DNA 170000000
    normal ultrasound and fibroscan of the liver,
    DOCTOR have gave me 6 month time but my report is same so my question is does my medicine start now ?
    what does my DNA tell me?

    • It is not uncommon for your liver specialist to repeat testing to see if anything changes with a few month’s time. Your SGOT/SGPT is elevated and you do have a high viral load so it would certainly be reasonable that treatment would be the next likely step – especially if your labs continue to present like above. Be sure to talk to your doctor about your options.

  124. Hello am 34yrs old lady.my last hbv test was done in 2011 with these results:
    HBV Viral Load-61 IU/ml
    GGTP-21.09 IU/L
    Bilirubin (tota)-0.43mg/dl
    Bilirubin (direct)-0.10mg/dl
    Bilirubin (indirect)-0.33 mg/dl
    SGOT-25.84 U/L
    SGPT-23.42 U/L
    Alkaline Phosphatase-69.59 IU/L
    Total proteins-6.69gm%
    Albumin-2.92gm%
    Globulin-3.77gm%
    A/G Ratio-0.8
    Albumin-2.92gm%
    Please help interpret the results and advise.was first diagnosed in 2008.hv 3 children within the period and all tested negative plus husband. Awaiting ur response.tnx

    • You have a chronic HBV infection, though your LFTs appear to be within normal limits – though you did not provide the lab provided ranges which vary. Your ALT (SGPT) is slightly elevated, (normal for women is 19 IU/mL), but this is likely due to lifestyle choices. (Ensure you maintain a healthy weight by eating a well balanced diet and getting moderate exercise, no alcohol and no smoking is advised)

      All those with a chronic HBV infection benefit from regular monitoring by a liver specialist to be sure your HBV status or liver health do not change over time. At this time you have a low viral load, which is good and makes you much less infectious. It indicates you are likely in what is considered an inactive phase of the virus. However, this can change with time.

      Should you decide to have more children, please be sure that all children receive the first shot of the HBV vaccine and a shot of HBIG within 12 hours of birth to prevent HBV transmission. Pregnancy can cause the viral load to elevate, which increases the risk of transmission to baby. Hopefully your children are were vaccinated at birth and completed the series. They should have been tested for HBV at their 1 year well visit and not at birth. A young baby may not initially test positive, so please check the dates of the test. Babies and young children are so vulnerable to HBV. 50-90% of babies and young children that are infected with HBV will have HBV for life.The younger the child, the more likely they will have a chronic infection if infected. I would also encourage you to be sure your husband is vaccinated too.

      Please learn more about chronic hepatitis B, and HBV transmission and be sure to discuss your results with your doctor and followup with regular monitoring. visit HBF’s website at http://www.hepb.org

  125. i am 27 and a male; my test shows…

    Bilirubin (total)-1.43mg/dl
    SGPT- 41 U/L
    hbv quantitative pcr – 800 iu/ml….
    Please help interpret the results and advise

    • You didn’t include the reference ranges noted by the lab for your bilirubin, though it appears a bit elevated. At this time your ALT is also elevated, though ALT can be elevated for different reasons. A normal level for men is 30 IU/mL and below and below 19 IU/mL for women. You do not say if you are HBeAg positive or negative. Regardless, your HBV DNA levels would not likely warrant treatment, but you should really discuss your results with a liver specialist. Are you certain you have chronic case of HBV or is is possible you have an acute case of HBV? A person is considered chronically infected if they test HBsAg+ for more than 6 months. Please discuss further with your liver specialist.

  126. Hi Sir,
    I am 29 years old and was diagnosed HB positive in 2009 and I have not been taking any medication till 2013 when my doctor prescribed Livoline to me. Below are the result of the tests i conducted recently in October, 2013. What is my HbV status and what advice do you have for me.
    1-Virology
    PCR=370 IU/mL
    2-Chemistry
    Bicarbonate=20mmol/L
    Chloride=107mmol/L
    Sodium=142mmol/L
    Potassium=4mmol/L
    SGPT=27u/l
    SGOT=24u/l
    Alkaline Phophatase=43
    Uric Acid=375
    Albumin=43gm/L
    Protein=80gm/L
    Bilirubin Total=15um/L
    Urea=3.9mmol/L
    Creatinine=83umol/L
    3-Haematology
    PCV=33.6%
    HB=10.1g/dl
    TLC=3.5mm3
    Neutrophils=29%
    Lymphocytes=64%
    ESR=3mm/hr

    Thank you

    • Livolin Forte is a supplement for the liver and is not medication used to treat chronic HBV. Your liver function tests appear normal – ALT or SGPT is often used as an indicator or liver activity and damage. Yours is within the normal range of 30 IU/mL for men. Remember that all labs should be noted with units and reference ranges since they may vary. Consider talking to your doctor about getting HBV specific testing to learn more about your HBV such as HBeAg, HBeAb and HBV DNA. This evaluated and monitored over time will give you a better idea of your HBV. Be sure to maintain a healthy lifestyle by eating a healthy diet, get regular exercise and be sure to avoid alcohol and smoking.

  127. Hello,
    Jamila is a female of 43 years old. She has undergone the HBV PCR (quantitative) with the following results:
    HBV DNA: Detected
    Viral Load: <35 copies/ml
    Please kingly guide on her condition and what should be done. Also, is it important to do HBsAg and HBsAb test for her as well?
    Thank you,

    • your viral load is very low at 35 cp/mL. You are likely in an inactive phase at this time. Please continue with regular monitoring and have your doctor look at your liver function tests – especially ALT and AST. your ALT should be 19 IU/mL or lower. If is elevated, talk to your doctor about diet and lifestyle changes, and see if a healthy diet and regular exercise make a difference in your ALT.

  128. Im 19 years old male.
    HBsAg Positive
    Anti HCV Negative
    HBeAg Negative
    SGPT 18
    SGOT 24
    HBV DNA QUANTITATIVE REPORT
    3304 IU/ml
    Exponential value : 2.E+04
    Log value: 4.28 copies/ml
    What is my condition ?
    Am i contagious ?

    • THere is no specific quantitative number that makes a person infectious or non-infectious. However you are not contagious since HBV is not transmitted casually. Your viral load is not extremely high, but it is certainly possible that you might be able to transmit to others through direct contact with infected blood and body fluids. It is best to take simple precautions by avoiding direct contact of your blood or infected body fluids with direct contact of others (open sores, mucous membranes, etc.). Keep open cuts, sores, bug bites etc. covered, practice safe sex and do not share personal items with others such as razors, toothbrushes, nail clippers, etc – anything that may have trace amounts of blood on them. Fortunately there is an effective vaccine to protect others from HBV infection. We always encourage vaccination when possible. Don’t worry about hugging, general kissing, cooking and sharing meals with others, going to school, working etc. At this time you seem to have HBe negative HBV. You will want to continue with regular monitoring by a liver specialist to keep track of your HBV and your liver health.

  129. hello sir,
    my HbeAg is 0.27 AI and
    Anti-Hbe, serum @ CMIA is 0.01 index and
    HBV DNA QUANTITATIVE is 63 IU/ml
    my doctor suggest me not to be worried. but i found no suggestion for whether i should take normal vaccination for this or not.

    • You appear to be infected with hepatitis B and have a low viral load of 63 IU/mL. I believe you are HBeAg negative, though your units and reference ranges are a bit confusing. Many of the treatments used to treat HBV are antivirals that work by lowering the virus level. If a person has a low or undetectable viral load, they are not typically recommended for treatment. However, since you do have HBV, there is no reason to get a hepatitis B vaccine. It will not do anything since you already have the infection.

  130. am 27 and a male; my test shows
    HBsAg positive
    HBeAG positive
    anti hbe negative
    SGOT/SGPT -60/90
    HBVDNA DNA 170000000
    normal ultrasound and fibroscan of the liver
    NOW DOCTOR START MY MEDICINE WHAT IS SIDE EFFECT .AND WHAT WILL HAPPEN IF I FORGET TO TAKE MEDICINE A DAY.

    • I would agree with your doctor’s decision to treat you for your chronic HBV. You do not say what kind of medicine you are taking, but I am assuming you are taking an antiviral such as tenofovir or entecavir. It is very important that you take your medication as prescribed, on a daily basis. Occasionally forgetting your medicine for one day will probably not be an issue, but you need to be sure you work hard to take the medicine daily. Stopping and starting an antiviral can cause a rise in your virus level which can result in a possible dangerous liver flare. your ALT (SGPT) is quite high at this time. Over time on the antiviral, your SGPT should normalize and your viral load should decrease to very low or undetectable levels. Even when this occurs, you must continue to take the medication as prescribed. Once again, if you stop – even after things seem to normalize, you will cause a problem if you stop the medication. The antiviral is controlling the virus so if you stop, it will go up and your liver enzymes will elevate. Please talk to your doctor if you have additional questions.

  131. Hi sir Sgpt(alt)71 , sgot(ast)30 , hbv DNA (quantitative viral load)255iu/ml , i take telbivudine tablets 600mg daily since 1year ,1year earilar my hbv DNA is 10million , I like to ask u sir my hbeag+and hbsag+ Are clear forever ? Or ?

    • You are having an excellent response to telbivudine since your viral load went from 10M to 255 IU/mL. Please talk to your doctor. It is very important that you stay on the telbivudine. Telbivudine is an antiviral that works by lowering the virus level by stopping it from reproducing. If you stop taking the medicine the virus will start replicating again very quickly. This could result in a dangerous flare and damage to your liver. You do not mention your HBeAg and your HBsAg? Has your doctor tested these hepatitis markers? Sometimes a person will seroconvert and lose HBeAg while on an antiviral, though it is not that common and it is very unusual to lose the surface antigen (HBsAg) and gain the antibody while on an antiviral. At this time, your ALT continues to be high, so you may wish to talk to your doctor about lifestyle changes that might have a positive impact on your liver. Avoid alcohol, avoid smoking and consider healthy changes to your diet and be sure to add exercise.

  132. i am 33years old woman. Not yet married.
    Hbasg positive.
    In scan report there is enlarged liver.enlarged spleen.ascitis occur.
    I am having hbasg positive and also cirrosis liver.
    In lft test sgot is 25, sgpt 27 , total protein is 6.0,albumin is1.7, globulin is 4.3total bilirubin 0.38, bilirubin direct 0.10, alkaline phosphatase 252 range.
    AFP range is 2.07
    HBV viral load >100000000.

    Before i have been operated for inguinal and incisional hernia.
    Before one year i taked tenofovir tablets.
    Now what can i do,Is anything serious in my body ? Now what can i do. Give me a suggestion.

    • Are you still taking tenofovir to control your HBV infection? You have advanced liver disease and should continue to take tenofovir to control the virus. If your doctor suggested that you stop taking tenofovir then I would consider a 2nd opinion with another liver specialist. Antivirals are typically taken for many years and even for life for those with chronic HBV – especially for those with advanced liver disease. Please talk to a liver specialist about your condition so you can be properly treated. At this time your viral load is very high and you are quite infectious, so you want to be sure to take precautions so you do not transmit the virus to others. Please seek the advice of a liver specialist.

  133. helo sir my hbv dna 355 iu/ml 2066copies/ml exponential value 5.e+06 log value “(copies/ml)3.32 what is my condition plz tell me sir

    • At this time you have a low HBV DNA viral load, and this is good. However, your HBV status and liver health is not defined by your HBV DNA level alone. Talk to your doctor to learn if you are HBeAg negative or positive and about the health of your liver. Discuss your health and family history with your doctor. Look at your lifestyle and consider changes you might make to improve you liver and general health. Be sure to see a liver specialist regularly to evaluate your HBV and liver health over time.

  134. please I was tested (because I am going to study abroad) and the result shows as follows
    HBsAg = Reactive
    HBeAg = Non Reactive
    HCV = Non Reactive
    please what does that imply?

    • You currently have a hepatitis B infection. I do not know if it is acute or chronic, so you will want to followup with additional testing. If you do not clear the virus (become HBsAg negative) in 6 months, then you are considered chronically infected. If that is the case, it is unlikely you will clear HBsAg. You can also ask your doctor to run an anti-HBc test IgM, and if this is positive, it is most likely an acute infection, and if it is positive then it is likely a chronic infection. Being HBV positive can be a problem depending on where you wish to study or work. You will need to look into the individual countries for specifics.

  135. Im 25yrs male. My tests show as follows,
    HBS ag +
    HBC IgM AB -
    HBC (Total) AB +
    HEP B E Antibody +
    HEP B E Antigen -
    HBV DNA – Not Detected
    All the liver function tests and scans were normal.

    Im anticipating to work in a middle-east country. But with HBS AG + they wont allow. My doctor said that it will be negative (HBS AG) within two or three months due to less viral load in the blood.
    Please advice on this.

    • You will need to follow up with testing with a hepatitis B panel (HBsAg, HBcAb Total, HBsAb). If you do not clear the HBV infection within 6 months, then your infection is considered a chronic infection. If you learn you have a chronic infection, it is very unlikely you would clear HBsAg, and this is a real problem if you wish to work in some of the middle eastern countries. At this time you are currently anti-HBc IgM negative, which indicates this is likely not an acute HBV case, but once again, you will need to follow up with repeat testing. If you learn you have a chronic HBV case, then you will want to be evaluated by a liver specialist.

  136. Im 19 years old male
    HbsAG POSITIVE
    HbeAG Negative
    Dna quantitative :
    21000 IU/ML
    LFT Is normal.
    Am i infectious now.
    Can i spread it.
    Please reply. Thanks in advance.

    • You need to take precautions to be sure you do not transmit HBV to others. This includes practicing safe sex or having sex with partners that are vaccinated to protect against HBV, and being sure to avoid direct contact of infected blood and body fluids. Be sure cuts, etc. are covered and be sure to clean up all blood spills with a diluted bleach solution. Please avoid sharing personal items that may have trace amounts of blood on them such as razors, toothbrushes, nail clippers, body jewelry etc. Please be sure to see a liver specialist for a thorough evaluation to determine if you would benefit from treatment at this time, or not.

  137. I have this results

    HBcAb … positive
    HBcIgm …negative
    HBsAg ….. positive
    HBSAG VALUE .. 576.78 IU/ML
    HBsAb … negative
    SURFACE Ab VALUE ..0.00 mIU/mL REF. 0.0 – 10.0
    HBeAg .. negative
    HBeAb ..positive

    I have some pains in the right top corner of my abdomen

    Any interpretation?

  138. rajesh srivastava

    HBsAg positive
    HBcAb positive
    HBsAb negative
    DNA load less than 20
    above condition is after taking tenfoveer (cipla) medicine …
    this was my condition before one year now am going again chek for HBsAg positive
    HBcAb positive
    can you suggest what will possibilities now ….

    • Tenofovir is an excellent antiviral that controls the virus and keeps it from replicating. You are having an excellent response. The medication is suppressing the virus, which is exactly what it should be doing. I would expect your viral load will continue to be undetectable. However, it is unlikely that you will serconvert and lose HBsAg and gain the surface antibody. Unfortunately, taking antivirals does not usually have that result, though it is possible. Please be sure to continue taking tenofovir as directed by your liver specialist. Abruptly stopping the use of this antiviral could result in a dangerous flare that could cause liver damage. Please discuss any concerns with your liver specialist.

  139. I am HBsAg Reactive (120.25) , HBeAg Non Reactive (0.302) , HBeAb Reactive (0.02) and Hepatitis B Viral Load is 3500 IU/ml Log Value 3.54 SGPT 20 and SGOT 24
    Any Trreatement is available and Can I use any Antiviral Tab Please Suggest

    • Talk to your liver specialist. You are at a point where you may have HBeAg negative hepatitis that may benefit from treatment, but maybe not. Your viral load is elevating, but not too high and your SGPT is 20. Normal SGPT is 30 IU/mL for men and 19 IU/mL for women. Your liver specialist may wish to continue monitoring before moving forward with treatment. It depends on your previous results, other LFTs and a judgment call by your liver specialist Making the decision and the commitment to treat is big, so please discuss this with your liver specialist. The best antivirals for use at this time are tenofovir and entecavir.

  140. HBSAG reactive
    Anti HBs n0n reactive
    HBeAg reactive
    Anti HBe n0n reactive
    Anti HBcIgm n0n reactive
    Anti HBcIgG reactive

    my d0ctor didn’t explain anything yet, instead he askme t0 undergo test the HBV DNA and SMPT SHOT, what d0es it mean? thank y0u

    • Sounds like your doctor is doing the right thing learning more about your HBV infection and your liver health. However I am not familiar with an SMPT shot?? Anyway, according to your results, it appears that you have a chronic HBV infection. This is indicated due to your positive anti-Hbs IgG reactive/ anti-HBs IgM negative results.

  141. Antigens Hbs indice : 5317 (ECLIA)
    Anti HBs 0 UI/L,
    Anti HbC 0

    From another laboratory,
    Antigens HBs > 250 Ul/ml

    Hello hepbtalk,
    Kindly help in the interpretation of these results. It is confirmed that I am a chronic carrier of HBV, however what are the threshold before one starts taking drugs for prevention of viral multiplication. My liver according to my doctor functions well. As it is usually the case with humans, I am a bit worried. Thanks in anticipation do your response.

    • These tests show that you are currently infected with hepatitis B since you are HBsAg positive. You say you are chronically infected so I assume that you have tested HBsAg positive for more than 6 months. I would encourage you to talk to your liver specialist about getting additional testing to learn more about your HBV and your liver health. You will want to know your HBV DNA (viral load), whether or not you are HBeAg/HBeAb positive or negative and how your ALT/AST and other liver enzymes look. Keep in mind that a normal ALT is now 30 IU/mL for men and 19 IU/mL for women, which differs a bit from the normal range for some labs. Your doctor will want to repeat these labs over time to determine if you are a good candidate for treatment. Remember that not everyone with chronic HBV is a good candidate for today’s treatments. Try not to worry too much. Move forward with more testing and learn if you are a good candidate. Since your doctor says your liver functions well there is no need to rush ahead and push for treatment that may not be needed. (However, keep moving forward…) You and your doctor want to make the best decision on what is best for you. It’s not quite as simple as having a cut-off value for a viral load.

  142. my husband latest result for hbv dna viral load is not detected.last time before he took tenvir 2 or three years ago it shows million.what is that mean.tq

    • So your husband had an HBV DNA viral load in the millions 2-3 years ago, but now he is on tenofovir and his viral load is undetectable? This is very good and would mean that your husband is responding well to his treatment. Please be sure your husband continues to take tenofovir as prescribed. Abruptly stopping an antiviral often results in replication of the virus which can lead to a liver flare and damage. Please have your husband talk to his liver specialist to be sure he understands his current situation with his HBV and liver health.

  143. Hi my hbsag is positive but my pcr is negative is there any treatment to remove hbsag virus from body? My hbseAg is also negative and antibodies are positive. My specialist told me that I dont need any treatment. Its the matter of clearing the virus frim body.plz help me

    • Sounds like you are in the inactive phase of the virus. This is a very good place to be with a person being HBeAg negative, with a low or undetectable HBV DNA and normal ALT and liver function tests. There are no treatments that will permit a person in the inactive phase to seroconvert and lose HBsAg and gain the antibody. I would agree that you do not need treatment at this time, but be sure to continue with regular monitoring.

  144. I just got the following report
    HBsAg(screening),serumby CMIA -non reactive (0.01)

    HBeAg Hep B envelope Antigen,serum by CMIA-non reactive(0.444)

    Anti Hbe-Ab to hep b envelope Ag,serum -non reactive (1.82)

    am I infected with the virus?

    my LFT parameters are all normal

    am I affected by the virus?

    • According to the results that you note, you are not infected with hepatitis B. If a person is HBsAg positive, then they have HBV. Perhaps you are HBsAb positive? This would indicate that you have immunity to HBV. If you have had a recent exposure be sure that you wait 4-6 weeks before testing since a person will not test positive for 4-6 weeks even if they have been exposed to HBV.

  145. My HBV DNA by Real Time PCR was negative some years ago. My ALT remains normal in every test. My Antibody test were also non-reactive . But my recent PCR qualitative test showed results as “detected”. What does it means . Am I in dangerous situation now.

    • If you are HBeAg negative/HBeAb positive, have normal ALT and LFTs, and have a low or undetectable viral load then you are considered to be in an inactive phase of the virus with little or no replication. It is possible that things are changing with your HBV status, but perhaps not. It depends on how much HBV DNA is now detected (over 2,000 IU/mL or under 2,000 IU/mL??) and how your ALT and other liver function tests look. Please talk to your liver specialist. You will likely require closer monitoring until you determine if things are changing with your HBV or if this is just a cycling of the HBV DNA, which is also not unusual. Please talk to your doctor.

  146. sir
    i am 28 year old & hep B carrier and my wife was infected by me but she self eradicated by-self and became HBSAG -negative .does she still need vaccination .and does i plan for baby .

    • I am sorry to hear that your wife got an acute infection, but glad to hear that she was able to clear it on her own. 90% of healthy adults will clear an acute (new) HBV infection. Your wife does NOT need to be vaccinated since she has already generated immunity on her own. Be sure that baby receives the first shot of the HBV vaccine before leaving the hospital and followup with shots in the series according to schedule. All will be good.

  147. Muhammad Farooq

    recently i have got my report of Hepatitus B DNA PCR quntitiative test… it was report that “no hepatitus DNA not detected and less than 60 iu/ml viral load”

    what do you suggest to me now?

    • This good news. You are likely in the inactive phase of the virus assuming you have a chronic HBV infection. If you are currently taking antiviral medication to control the viral load, then be sure to continue taking the medication. Abruptly stopping an antiviral can result in a flare that can cause liver damage. If you are not currently taking an antiviral, then you likely do not require any medication since you are in this inactive phase.

  148. I am being diagnosed with Hepatitis B showing HBsAg screen-Positive
    The following tests followed
    HBeAg-Negative
    Hep B Viral Load PCR 1,810 IU/ml
    Can I be treated and if so, which drug could be recommended for me. Is Truvada the right choice for me

    • I would encourage you to have this conversation with your liver specialist. A few things to consider: Are your ALT/AST levels elevated? Have you been tested over a period of time to be sure your viral load is consistently elevated? Is there a family history of HBV? How is your liver and general health? Is there any apparent liver damage with evidence of an ultrasound, Fibroscan or a liver biopsy? The level where you are at this time is sort of a gray area and the decision to treat or not varies with the liver specialist. 2,000 IU/mL and up for those with HBeAg negative HBV may be treated though they may not be. Should you and your doctor decide to move forward with treatment, discuss the resistance profiles of available antivirals.

  149. Hi.
    My wife has got HBsAg positive. He is 29 years old. Height is 5 feet 2 inch and weight 63 kg.
    There is no family history of HBV.
    The below are my wife’s detail diagnosis results:
    *HBsAg: Positive (Screening & Confirmatory)
    *HBeAg: Negative
    *SGPT: 224 (Initially it was 3005. 18 days ago)
    *BILIRUBIN: 1.1 (At first it was 1.8. 18 days ago)
    *DNA test not done yet.
    Pls answer my below questions:
    1) What % is the chance that body will create antibodies & make HBsAg latent/Neg after 4/6months?
    2) What if body couldn’t create antibodies?
    3) I’ve taken Hepatitis B vaccine 15 years ago. Now if I do sex with my wife without condom or oral contacts, will the virus transmit or any risk?
    4) My 5 months old boy already taken HBV vaccine. Now is there any risk of vertical transmit of visus?
    It’ll be a great help if you can help me by answering the above questions.
    Regards
    Md. Habib

    • 1. If this is an acute (new) infection then there is a 90% chance your wife will clear the virus. You can ask your doctor to run an anti-HBc IgM test, though you will still need to wait the 4-6 months to confirm if she has cleared an acute infection or if she has a chronic infection. 2. If she has a chronic infection then your wife will need to get further testing to determine if she is a good candidate for treatment. She will need to be regularly monitored by a liver specialist and she may need to make some lifestyle changes. 3. You are likely good, but if you wish to confirm your immunity, you can have your anti-HBs titers checked. It is possible they have waned over the last 15 years. if that is the case, get a booster shot and re-test your titers a month later. Until you are sure you should practice safe sex using a condom. The vaccine protects you from all exposures so you should be good. 4. Your 5 month old son should have received 2 of the 3 shots of the vaccine series if he is following the schedule. With 2 out of 3 shots of the series, he will have up to 80% protection. You might wish to have his anti-HBs titers checked at this time to check his immunity.

    • If this is a new infection, called an acute HBV infection, then there is a 90% chance that your wife will clear the infection. This is a assuming that in general your wife is healthy. Please continue with regular monitoring of your wife by a liver specialist since her ALT (SGPT) was so high. Since she is being carefully monitored, your wife will be re-checked and hopefully she will clear the virus and lose HBsAg and gain the antibody. Be sure to followup.
      YOu should be protected if you received all 3 shots of the HBV vaccine series. However, if you wish you can have an anti-HBs titer run to confirm. If it is below 10 IU/mL then you can get a booster shot. If you are protected then you do not need to worry about getting infected due to unprotected sex.
      The biggest concern is with the timing of your wife’s HBV infection and the birth of your child. A 5 month old child would have received 2 out of 3 shots of the HBV vaccine. Do you know if your wife was infected with HBV when she gave birth to your son? If she was infected at the time, did he also receive a shot of HBIG?
      Transmission of HBV is through direct contact with blood and infected body fluids. Be sure your wife takes care to cover all cuts, sores etc. Avoid chapped skin by using lotions and be sure to keep personal hygiene items personal to avoid sharing razor blades, toothbrushes, nail clippers, etc. All feminine hygiene products should be carefully disposed of. Please be sure to repeat testing to be sure your wife clears her infection. If you learn this is not an acute infection, then you will want to have your son tested since HBV is very effectively and inadvertently transmitted from an HBV+ mother to baby during delivery.

  150. Hi,
    On June 2010, i was diagnosed with immunotolrant phase of chronic hepatitis B, based on the below results:

    HbsAg: reactive
    HbeAg: reactive
    Anti-hbe: reactive
    HbvDNA: 5,740 IU/ml
    No treatment was recommended by my doctor.

    Just yesterday, my doctor advised me to have my sgpt and HbeAg checked, and i got these results:

    Sgpt: 11.0
    HbeAg: non reactive

    What does that mean? Can i still work in california, given my situation? Thank you very much?

    • Looks like you may have serconverted losing HBeAg and gaining the antibody. When this happens your viral load typically goes down significantly. I don’t know what your viral load was previously. Your ALT has completely normalized. Normal for men is less than 30 IU/mL and 19 IU/mL for women. Your doctor will likely want to re-evaluate your ALT (SGPT) and your HBV DNA in the next few months. There is no reason these results should interfere with any work you are doing in California. Please try not to worry.

    • It looks like you are moving into an inactive phase of the virus. You recently seroconverted and lost HBeAg. If you have gained the HBe antibody and have a very low or undetectable viral load and normal ALT then you are considered in an inactive phase. There is no reason you cannot continue to work in CA.

  151. I tested positive for hepb 8 yrs ago when I was going to get my vaccine. Everyone else in my family was negetive. It was a very traumatic experience for me because I hadn’t had any prior sexual contact, never shared needles or done drugs and I haven’t had any blood transfusion. Still baffled as to how I got infected.
    I’m now 29 and have never been symptomatic. . I recently did my tests after ignoring it for almost 6 yrs. Results are as follows
    Alt and Ast are within normal
    Hbsag -positive
    Hbsag _ negetive
    Hbeag- negetive
    Hbeab- positive
    Hbv Dna copies -250 cp/ml
    Hbv Dna – 43 Iu/ml
    Is it possible that I would achieve seroclearance any time soon?

    • I am sorry to hear of your chronic HBV infection. You are not alone. Many have no idea how they were infected. It can be unsettling, but know that many in the world are living with chronic HBV and most were infected when they were very young. YOu are in a good place with your HBV. It would be considered an inactive phase. However, it is unlikely you will serconvert and lose HBsAg and gain the antibody. There is a small percentage – 1 to 2% per year who will serconvert spontaneously and lose HBsAg. Please continue with monitoring by your liver specialist to be sure there are no changes to your HBV over time.

  152. Im 25yrs male. My tests show as follows,
    S. Bilirubin 5.4 mg/dl
    HBs Ag (Elisa) Positive = Cut off value 0.255
    HBS ag +
    HBeAg = Reactive
    Anti-HBe = Negative
    Anti-HBC IgM = Reactive
    USG W/A+HBS = Normal sonographic findings
    SGPT = 1000 U/L
    HBV DNA = Detected Viral Load: 50000000 IU/mL OR 250000000 Copies/mL
    All the liver function tests and scans were normal.

    Please advice on this.

    • It looks like you have an acute (new) HBV infection. YOu will want to be sure to continue monitoring with your doctor and return for repeat testing. A person is considered chronically infected if a person continues to test HBsAg+ after 6 months. The good news is 90% of health adults newly infected with HBV will clear the acute HBV infection. However, its essential you re-test to be sure. While you wait, please take precautions since you are very infectious at this time. HBV is transmitted through direct contact with blood and infected body fluids. HBV is also sexually transmitted so please practice safe sex and be sure partners are screened for HBV. There is a safe and effective HBV vaccine to protect others from getting HBV. Be sure to take care of your liver health. Do NOT drink alcohol and take prescription or over the counter drugs only as recommended. If you have questions, ask your doctor. In general, eat a healthy well balanced diet.

  153. lft sgot 35, sgpt 40units/L pcr dna viralload 731 iu/ml (3.8iu/ml:iu/ml=6) six months prior hbe -negative.
    when i should start medicine . pl tell what is the present copies of 731iu/ml means my age is 40 and mother is advise me to get married what do pl help

    with regards
    hemanth

    • There is no reason you should not get married. There is a safe and effective vaccine to prevent the transmission of HBV, so there is no reason you cannot marry and be sure your future spouse is vaccinated to prevent transmission of HBV. I would encourage you to consult with a liver specialist about your HBV. Your viral load is not too high and would normally not require medication, but you want to talk to your doctor. your ALT is elevated, but it is very possible it is related to diet and exercise. Once again, this something you want to discuss with your doctor.

  154. Hi,
    My 16 year old friend was diagnosed with chronic HepB last April. Her blood tests are as follows: HBeAg pos.. Anti Hbe neg. , Anti HBC pos. Viral Load 88247 copp/ml. AST 104 u/l , ALT : 134 u/l , ALP 153. The Dr. suggested to wait for further test before treatment. Now her latest test shown a huge increase of Viral Load 5,936,400 copp/ml
    Or 1,020,000 iu/ml. HBeAg remains positive. ALT 81, AST 78, ALP 148. U/S shown a mildly fatty liver. The Dr. Is still reluctant to start treatment. Is it wise ? Will the HBV damage the liver further ? Which is the best treatment for her age ? Please advise. Thanks.

  155. My 16 year old friend was diagnosed with chronic HepB last April. Blood tests results as follow: HBeAg Pos. Anti Hbe Neg. , anti HBC Pos., viral load 88247 copp./ml. Alt 134u/l, AST 104u/l. The Dr. suggested to wait for further tests before treatment. Now, the latest test still show Pos. To HBeAg and a massive increase of viral load to 5,936,400 copp/ml. Or 1,020,000 iu/l. AST 79, ALT 81. U/S shown a fatty liver. The Dr. Is still reluctant to start treatment. Is it wise ? Will the HBV cause more damage ?
    What is the best treatment for her age ? Thank you.

  156. Hi. I was diagnosed for chronic hepatitis B, and went for DNA viral load test, and it read 170000000 DNA IU/ml. Kindly help me with this interpretation and what to do next. Thanks.

    • You want to take to your liver specialist to learn more about your HBV and liver health. I am assuming you are HBeAg positive since your viral load is so high. I don’t know your age, but most likely you are younger and you are in the immune tolerant stage. You’ll want to confirm this with your liver specialist. If this is the case and you are young, then it is possible that your liver specialist will choose not to treat you. This would not be at all uncommon, but varies with the patient, their family history and other factors. Please do keep in mind that you are quite infectious at this time, so please take care to be sure you do not transmit the virus to others. Be sure to avoid direct contact with blood and infected body fluids. Be sure all sexual partners are vaccinated or be sure to practice safe sex with a condom. Once again, please speak with your liver specialist.

  157. Need information about combination of normal Liver function, HBsAg+ Igm- HbeAg- Anti Hbe-
    First of all it is good to see some helping hands in this forum.I thanks enough you all because of great advice you have been giving to all over the world. You already answered many question for many years to may people now i am really seeking a help from you.

    Liver Function Test : Everything is normal

    Liver Function Test Value Cut of Value
    Total Bilirubin(DPD) 0.71 mg/dl 0.3 – 1.2 mg/dl
    Direct Bilirubin(DPD) 0.16 mg/dl < 0.2 mg/dl
    Indirect Bilirubin(Calculated) 0.55 mg/dl NA
    Total Protrien(Biuret) 7.9 g/dl 6.6 – 8.3 g/dl
    Albumin(BCG) 4.9 g/dl 6.6 – 8.3 g/dl
    Globulin(Calculated) 3.0 g/dl 6.6 – 8.3 g/dl
    AG Ratio(Calculated) 1.6 6.6 – 8.3 g/dl
    S.G.O.T[A.S.T](IFCC) 34.0 U/L < 35.0 U/L
    S.G.P.T[A.L.T](IFCC) 43.0 U/L < 45.0 U/L
    GAMMA GT(IFCC) 17.0 U/L 3.500 0.423 Positive (HBsAg +)
    Hepatitis B ‘e Antigen 0.01 <0.1 -ve Negative (HBeAg -)
    Hepatitis B Core Antibody 4.0 <5.0 -ve Negative (Igm,
    Anti HBc Igm) Hepatitis B 'e Antibody 0.01 <0.4 -ve Negative (Anti HBe -)

    1)Is he acute or chronic.Is there any danger to his life?
    2)What does HBeAg Negative and Anti HBe Negative say?
    3)Should we start any medicine to control the virus?
    4)Is value of A.S.T. and A.L.T alright?
    5)Is there any hidden danger with HBeAg – ?

    Thanks a lot again for all your support!!!!!

  158. I was diagonised with HBSAG +ve when I went to donate blood in 2011 .Since then I am doing routine checkup every 6-8 months with LFT , HBV DNA & Ultrasound . Below is my latest report

    LFT :
    ALT : 39
    AST : 69

    Ultarsound : Fatty liver with fat sparing

    HBV DNA : undetectable

    HBEAG -VE

    HBSAG : 66.6 IU/ML

    HEPATITIS B SURFACE ANTIBODIES, : 2.6
    QUANTITATIVE

    BMI: 22

    Based on this report my doctor told me its still inactive & I dont need any treatment . Please suggest

    1) me whether I am very contagious ??
    2) Whats my current health of my liver
    3) What chances are there that I’ll get liver complications later in my life ??

    Thanks in advance .

    • Pratap, You are smart to regularly monitor your HBV and liver health. At this time you are in good shape with your HBV. Your HBV DNA is undetectable and you appear to be in an inactive phase of the virus and would not benefit from the treatments available at this time. However, your ALT is a bit elevated. Normal ALT levels for men are 30 IU/mL or lower for men. Your elevated ALT is likely as a result of you fatty liver disease. If you haven’t already, speak to your liver specialist about healthy lifestyle choices you can make to help reduce your fatty liver disease. Your repeat ultrasound and ALT results will help your doctor monitor your fatty liver, which can also result in damage to the liver. At this time you are not contagious since you have no viral load, but keep in mind it is still best to take very basic precautions in case your HBV changes with time. With vaccination it is easy to keep family and partners safe from any risk of hepatitis B. It’s impossible to know your specific risk for liver complications over time, including liver cancer. Be sure you are also getting regular liver cancer surveillance along with your HBV monitoring. This is important because sometimes liver cancer can present even in those that do not have extensive liver disease or cirrhosis. Fatty liver disease can also lead to damage to the liver so be sure to do what you can to make health lifestyle choices and continue as you are doing with the regular monitoring.

  159. Good day!

    I just had my Hepatitis B profile last month and found out that I am a Chronic Hepatitis B carrier. Most likely, I probably have it since I was young and just found out after the test. I haven’t experienced any symptoms related to this disease. I had my liver ultrasound and the result is perfectly fine,nothing is wrong, and it is normal. I went to a gastroenterology doctor and she suggested me to undergo medication because my viral load is quite high. She suggested to take Entecavir ( Entegard) .5mg for a daily basis. Is it fine to take this medicine base on the lab results below? I really need to get my HBsAg reactive to become non-reactive. Please I need your pieces of advice. Thanks!

    RECENT LAB RESULTS:

    Test Cut-off Values Patient Value/Result

    HBsAG 1.0 4108.23 Reactive

    Anti-HBs 10.0 0.84 Non-Reactive

    HBeAG 1.0 0.375 Non-Reactive

    *************************************************************************************************
    Test Result Normal Value

    ALT/SGPT 47.0 21.00 – 72.00 u/l

    **************************************************************************************************

    HBV DNA VIRAL LOAD (Real Time PCR)

    Result : 8,101,945 IU/ml

    Remarks: 1.) HBV DNA Viral Load (Real Time PCR) detection limit:
    8 – 110,000,000 IU/ml (35-840,200,000 copies/ml)

    2.) Specimen with less than 6 Iu/ml (640,200,000 copies/ml) is above the defined range of the test.

    ************************************************************************************************************************************
    LIVER ULTRASOUND RESULT

    The liver is normal in size. Parenchymal echogenicity is homogeneous. No solid mass or cystic lesion is noted. No parenchymal calcifications are seen. The intrahepatic ducts and vessels are not dilated. Negative for ascites.

    IMPRESSION:
    SONOGRAPHICALLY NORMAL LIVER

    ***********************************************************************************************************************************

    Questions:

    1. Is it required for me to take Entecavir (entegard) .5mg based on the lab results above?
    2. If so, is it safe to take it without any scary side effects like renal or kidney problems?
    3. I’m planning to take it only for a month and have my HBV DNA again it the medicine works, is that even possible?

    Please, I really need your pieces of advice. Thank you!

    • You are currently HBeAg negative, but your HBV DNA is high indicating you are not in the inactive phase of the virus and likely have an HBe mutation. Your ALT is actually a bit elevated. The upper limits of normal for men is <30 IU/mL and yours is 47. Has your liver specialist suggested that you go on antiviral treatment? This would likely be recommended by most liver specialists, so you may wish to discuss this with your liver specialist. When you start antiviral treatment it is a commitment. It is not recommended that you abruptly start and stop taking an antiviral. You will likely be on entecavir for years or possibly for life because antivirals like entecavir or tenofovir work by controlling the virus, but when you stop taking them, the virus starts replicating again and can result in a dangerous flare that can cause liver damage as your ALTs elevate. Please be sure you understand this and discuss following the treatment protocol directly as advised by your liver specialist. Most people do not experience side effects with entecavir, but talk to your doctor if you are having problems. Ask your doctor about getting baseline kidney function tests. Hope this helps.

      • My anti-hbe is reactive, is it good or bad? What if after taking the entevir for several months and have my DNA test again and the result I hope is undetectable, do I still need to continue taking the entevir? I am probably living with it since I was a kid and didn’t complete the vaccination for Hepatitis B because I am asymptomatic. I used to drink a lot of alcohol also but thank goodness my liver was perfectly fine when I had it ultrasound.

        • Being anti-HBe reactive fits with being HBeAg negative. When the antigen is positive, the antibody is typically negative and vice-versa. You will need to stay on entecavir until you serconvert and lose HBsAg and gain the antibody. This means most likely you will be on entecavir for life. The entecavir will bring down your viral load, but as soon as you stop taking it, your viral load will begin to rise and you will likely have a liver flare that can be dangerous resulting in damage done to your liver. Please talk to your liver specialist about your situation. You need to understand the importance of taking your medication exactly as prescribed. Please do not drink any alcohol at all. Please talk to your doctor about your treatment with entecavir and the importance of taking the medication as directed.

          • Thanks a lot for your pieces of advice! The thing is, we will be moving to the USA next month and when we asked the price of entecavir, it is crazy expensive. The 30 pills cost $1300.00 and there’s no way I can afford it because I will still look for work when I get there. The other option is, I might just buy the entecavir from the Philippines and let my sister send it for me to the states. I just hope it will work that way.

          • Not sure what to advise. If you will soon be moving to the US then you will want to be sure you are able to continue taking the medication. You don’t want to stop taking entecavir because it can result in a flare that can cause damage to the liver. It does take time to look into programs that you may or may not be eligible for in the US, so you will want to be sure you are able to get your medication – perhaps from your sister, though there may be problems shipping prescription drugs from an individual. I can’t really say. You will also want to look into seeing a hepatologist in the US to who will continue with the monitoring of your HBV and liver Health.

      • Yes, my gastroenterologist suggested to undergo medication by taking Entecavir (entegrad) .5mg which I am taking it nowadays. I just hope this won’t diminish my appetite for exercise like running 5 miles for 35 minutes every session at the gym. :-)

        • Taking entecavir should not interfere at all with your workouts. Exercise is actually good for those living with chronic HBV – whether they are being treated or not. Keep up your exercise routine.

  160. I have just tested HBD DNA copies of 90,967 IU/ML and I am 38years.
    what is my condition please, I am scared, I need advice even though I am fine.

    • I would encourage you to see a liver specialist to learn more about your HBV and liver health. Your HBV DNA is elevated, but there is other important information to consider, and your doctor may wish to follow you over a period of time. Knowing whether or not you are HBeAg positive or negative, and liver function tests such as ALT/AST (normal ALT is <30 IU/mL for men and 19 IU/mL for women) and other tests are important. Current health and family history are also very important. Please speak with a liver specialist to learn more about your situation.

  161. Hi,
    i have HBV viral load count is 92,200 IU/L when tested 8 months back. My test results are as follows.
    Total bilirubin – 0.70 mg/dL
    Bc (Conjugated) – 0.20 mg/dL
    Bu (unConjugated) – 0.50 mg/dL
    Alkaline Phosphatase – 62.00 IU/L
    SGOT – 22.00 IU/L
    SGPT – 40.00 IU/L
    Total Proteins – 7.50 gms/dL
    Albumin – 4.00 gms/dL
    Globulin – 3.50 gms/dL
    A/G Ratio -1.14

    HBeAB – 0.010, Reactive, CMIA method
    HBeAG – 0.39, NonRecative

    Please suggest me.

    • I would start by talking to your liver specialist and repeating your tests. It is possible that you were in the process of seroconverting at the time of these tests, but there is also the possibility that have HBe negative hepatitis B. Please repeat testing and discuss your new results with your liver specialist.

  162. Hi my test results are as follows : HBV DNA 42100 UI/ml, AST 23 u/I , ALT 37 u/l , hbeag reactive 5.13 , my doctor has advised me to take telbivudine 600 mg , is it ok to take this drug or should i wait

    • Take a look at management guide that compares AASLD, EASL and APASL guidelines http://www.natap.org/2014/HBV/011614_01.htm and discuss them with your doctor. Your HBV DNA is elevated within the treatable range for a person that is HBeAg positive, and your ALT is elevated (normal is < 30 IU/mL), but not too high. Consider your general health, liver health, family history, and how long your have been monitored by your liver specialist.

  163. aprilyn adorable

    Hi I would like to ask if its safe for me to undergo liposuction/tummy tuck if i have this results of my hbv dna viral load: 855.54 copies /ml alt sgpt 10-35U/L? Thanks

    • I wouldn’t think it would be a problem, but be sure to let your surgeon know of your HBV infection prior to the date of surgery.

  164. hi my test results r
    hbe ag non reactive( 0.367)
    hbc ab lgm non reactive (0.07)
    hbs ab non reactive (0.41)
    hbv viral load is 2.8 or 628 il/ml
    hbs ag reactive
    sgot (ast) is 23 u/l
    sgpt (alt) is 30 u/l
    what does my test results show

    • You seem to have a chronic infection (negative HBcAb IgM), but you appear to be in the inactive phase based solely on these results. You are HBeAg negative, your viral load is low 628 IU/mL and your ALT/SGPT is within range (at or below 30 IU/mL for men, 19 IU/mL for women). Regular monitoring of your HBV and liver health is very important so be sure you continue with monitoring to ensure there are no changes over time. Be sure to also ask about regular liver cancer surveillance. And lastly be sure you take care of your liver by adopting a healthy lifestyle including maintaining a healthy weight through a well balanced diet and regular exercise and no alcohol and avoiding smoking.

  165. Hi,

    My mum is a renal patient and has to undergo dialysis every few days. Now her condition has been further complicated by the detection of HBV. We conducted a DNA test recently that showed substantial viral load. We wanted to begin therapy for her virus and went to a doctor who asked us to do an ELISA test. Is it is required after the DNA test?

    Also, could you please tell me the difference between the DNA and ELISA tests and what are they used for?

    Thank you.

    Kazu

    • I am sorry to hear of your mother’s additional complication of HBV along with her dialysis. The ELISA test are merely hepatitis B serologies. (HBsAg, HBeAg, HBeAb, HBsAb, HBcAb IgM etc.) This will give the doctor more information about her HBV infection. (Acute, chronic, stage of the virus etc.). The DNA basically tells you your mother’s viral load or how much of the virus is found in the blood. The higher the viral load, the more infectious. I would encourage you to get a consult with a liver specialist to be sure your mother is carefully evaluated.

  166. Hbsag….positive
    hbsab…..negative
    hbeag……negative
    hbeab…….positive
    hbcab…….positive
    hbcabigm…..negative

    comments. Chronic hbv infection with a non replicating virus.

    Viral load=44581.2 copies/ml

    can I start medication?

    • Actually your virus is replicating and is not non-replicating. Your viral load is 44,581 cp/mL or roughly 9,000 Iu/mL and 14,000 or 9,000 IU/mL and you are HBeAg negative. I would encourage you to speak to your liver specialist about your results. He will be able to look at your results over time and results etc from your ultrasound that will help determine if you are a good candidate for treatment at this time. You did not mention your ALT/SGPT levels which are also important in determining if you are a candidate for treatment. Take a look at a comparison of guidelines and share it with your doctor. http://www.natap.org/2014/HBV/011614_01.htm

  167. Currently I am taking Viread 300 mg once a day for the past one year and half. I was diagnosed in 2010 with chronic hep B. I used to have viral load of 500 and HBeAg negative. my LFT remains elevated ALT – between 42-53, AST 20-30, viral load undetectable. Is this mean that the medication is working? Since I started the medication my liver ultrasound appears having about 1 cm lesson. Something I never had before treatment. My doctor said nothing to worry about. Is this normal. Is my liver suppose to get better after undetectable viral load.

    • Viread is controlling your HBV infection – you have an undetectable viral load. This would indicate that your ALT is a bit elevated for reasons other than HBV. Talk to your doctor about other reasons for an elevated ALT and consider making lifestyle changes that include diet and exercise changes. Do you know if your ultrasound shows evidence of fatty liver disease? Sometimes this can cause elevated ALT. It is certainly possible that you lesion is not of concern. If you remain concerned, you could consider a second opinion. Is your doctor doing regular liver cancer surveillance on you? Please talk to him about your results so you do not worry.

  168. Hi sir
    I have hepatitis b positive and antigen is 0.39. Antibody is 0.010
    And dna is 527
    Lft is normal

    Please suggest me sir how can I do positive to negative. Dr suggest me no treatment required but I have chronic hepatitis b.

    • An HBV DNA of 527 is very low regardless of whether or not you are HBeAg negative or positive, and your ALT is normal. Sounds like you are in the inactive phase of the virus and would not benefit from treatment at this time. Continue with regular monitoring of your HBV and liver health and continue discussing your results with your liver specialist. There is no treatment currently available, that can guarantee that a person will lose HBsAg and gain the antibody.

  169. My dna is 3952 sir can be positive to negative sir

    If you know about best place for treat this I always thankful to you boss.

    • You do not mention if you are HBeAg negative or positive. Continue with regular monitoring since your HBV DNA levels often fluctuate over time. If they continue to elevate and if your ALT begins to elevate, you can certainly discuss treatment with your liver specialist. If you have a liver specialist that you like, I would get treatment there assuming that you one day require treatment.

  170. HBeAg : 0.40 – NONREACTIVE
    HBSAg : >250 – REACTIVE
    ALPHA-FETOPROTEIN: 4.33
    HBV VIRAL LOAD : 73 IU/ML
    BILIRUBIN : 1.40
    SGPT : 38
    SGOT : 22
    Upper Abdomen ultra sound: All Ok
    HCV : Negative

    Dr. says its chronic, no treatment and monitoring every six month for rest of the life

    I am 42 years old, what is the risk to me & when this virus could have contacted me?

    Thank you.

    • You appear to currently be in an inactive phase of the virus. You are HBeAg negative and your viral load is very low at 73 IU/mL. There appears to be no benefit to treatment at this time. Please continue with regular monitoring of your HBV and liver health as your doctor suggests. Your ALT is a bit elevated with normal levels at or below 30 IU/mL for men and 19 IU/mL for women. Often this is diet and exercise related. Talk to your doctor about positive diet and exercise changes you can make. It’s impossible to say how or when you were infected with HBV, but most with chronic HBV were infected as babies or young children, who are most vulnerable to HBV as a result of their immature immune systems. Those with chronic HBV are at greater risk for chronic liver disease and the possibility of liver cancer which is why regular monitoring is so important.

  171. It’s tough to understand the situation for person like me who came to know all this one week back only. Do I have any chance to get rid of HBSAg? Does the following reading between 2 reports indicate anything?

    Reading 08/04/2014 22/06/2013
    ———————————————————————————
    PLATELET COUNT 252 204
    NEUTROPHILS 49 36
    EOSINOPHILS 3 25
    BILIRUBIN 1.40 1.10
    ALT 38 37
    AST 22 18

    • It is very difficult to learn of a chronic illness like HBV and wonder how you could have gotten it. It is an adjustment. I would encourage you to learn as much as you can about your HBV and liver health. Take a look a the information on HBF’s website and on this blog or keep up with current HBV news through our social media outlets. Normal ALT for men is 30 IU/mL or below or 19 IU/mL or below. I don’t know enough about your HBV to know what stage you’re in. However, most people who have a chronic infection will not clear HBsAg and gain the antibody (seroconversion), which if course is what most people wish to do. However, 1-2% of those chronically infected will clear HBsAg spontaneously every year and there are some that will respond on treatment, though most treatments control the viral load and do not clear HBsAg.

  172. SUDHIR PANIGRAHI

    i have checked my blood test and it’s found Hepatitis B positive
    now what can i do and how it will be removing this virus. pls suggest and advice
    i’m very worry about this

    Regards
    sudhir

    • First learn if you have an acute (new) infection or a chronic infection. A person is considered chronically infected if they test HBsAg positive for greater than 6 months. If you have an acute infection, there is a very good chance you will clear the virus on your own without any medication.If you have a chronic infection, then it may be a condition you live with for many years or lifelong. The problem is that many people have no idea if they have an acute infection or a chronic infection since there are often no symptoms for decades. You can ask your doctor to run an anti-HBc IgM test. If this test is positive, it usually indicates an acute infection. Regardless be sure to retest to learn if this is an acute or chronic infection. If it is chronic, see a liver specialist to learn more about your HBV and liver health. While you wait be sure you take care to not transmit HBV to others. Avoid direct contact with blood and have protected sex unless sexual partners have been vaccinated to protect against HBV. Be sure you avoid alcohol at this time and take care with prescription and OTC drugs.

  173. Just found one more old report of 25/04/2011 with few parameters tested …
    PLATELET COUNT 262
    NEUTROPHILS 57
    EOSINOPHILS 03
    BILIRUBIN 1.07
    ALT 46

    Please suggest if this indicates something.

    • The ALT is elevated in this report too. It might well be related to your HBV, but could also be due to other lifestyle choices (diet, exercise etc). Be sure to talk to your doctor and see if he can run more HBV specific tests such as HBeAg, HBeAb, and HBV DNA. Sometimes it is necessary to be monitored for a time to learn more.

  174. I am 32 years old, I was detected hbsag +ive 3 years back but the viral load was below 500 iu/ml, but recently there was an increase in viral load to 35000 iu/ml. My doctor prescribed antihep .05, i am taking the medicine from past 04 months, two days back i went for hbv dna and found that the viral load has decreased to below 90 iu / ml. Little increase in Alt and Sgt. Hbeaf -ive. Kindly suggest what does this mean.
    Thanks

    • It is not unusual for viral load to fluctuate. However, your viral load had increased by more than an order of magnitude, and then back down again so it’s possible that you have been having flares. That is why regular monitoring is so important so you can see what the trend is with your HBV and your viral load and liver function tests. You want to look at your viral load and your ALT labs and see how they relate. It is possible that you have moved into an inactive phase of the virus where you have normal ALT, HBeAg negative and low or undetectable viral load. Talk to your doctor and ask him to also check your HBeAb. Keep following this closely (HBeAg, HBeAb, HBV DNA, ALT) so you can determine if you continue to cycle up and down. It is best if you can avoid these flares that can result in liver damage. If this was part of moving into the inactive phase, that is fine, but if it continues, you might wish to discuss whether or not you are candidate for treatment.

  175. i went to do hepatitis viral load ant read:

    HBV DNA Copies:1245 cp/mL
    Hepatitis B virus DNA 214 IU/mL
    the linear reportable range of the Roche Taqman assay is 20 – 170,000,00 IU/mL
    Results below the limit of detection of 9 IU/mL will be reported as “Not Detected”.
    What is the meaning of all these?

    • They’re explaining the range of the test. The test is very sensitive, but some HBV DNA tests are more sensitive then others, so they give you the ranges so that you know where you fall. So this test cannot detect less than 20 IU/mL of HBV in the blood or more than 170M IU/mL. Your HBV DNA is 214 IU/mL which is low and would likely put you in the inactive phase of the virus. However, it is good to be sure you continue with regular monitoring of your HBV and liver health.

  176. I am 23 years old. male
    i have Hbsag +
    SGOT 30 u/i Normal value upto 42
    SGPT 25 u/i Normal Value Upto 40
    Bilirubin 0.7 mg/dl Normal upto 1 mg/dl
    my abdomnel ultrasound conclusion is = unremarkable study
    HBV DNA Viral load 9636 copies IU/ml

    Can i recover from this completely?
    can i reduce my viral load?
    i never had any symptom of hepatitis b….

    • You must first determine if you have an acute HBV or a chronic HBV infection. A person is considered chronically infected if they test HBsAg positive for greater than 6 months. I would encourage you to talk to a liver specialist about your results if you learn you have a chronic infection. You may also wish to see if you are HBeAg negative or positive. This will give you more information about your HBV. If you have a chronic infection, most likely you will not completely get rid of the infection. If you learn this is an acute infection, you will most likely clear it. That is why it is very important that you retest and get a hepatitis B panel run (HBsAg, HBcAB, HBsAb) 6 months from the time of your first test to confirm. Most people with chronic HBV have few or no symptoms for decades so they are surprised to learn of a chronic infection. Those with an acute infection may also have no symptoms. In fact approximately 70% of those acutely infected will have no notable symptoms.

  177. i was diagnosed last 9months
    hbs ag reactive 8451 IU/ml
    HBe ag non reactive
    anti hbs non reative
    anti hbe reactive
    anti hbc reactive
    sgot74
    sgpt 60

    so my doctor given meINTERFERON ,medicine
    after 3 months i went for hbv dna test and liver profile
    hbsag reactive 2831
    same result for the other profile
    sgpt 30
    sgot 34
    my HBV DNA result is < 6`iu/ml

    so i continue the interferon
    after 6 months i went again for my blood test
    hbs ag reactive 5400 iu/ml
    other profile same
    sgpt 28
    sgot 22
    HBV DNA undetectable

    so i continue again the interferon
    after 9months this month i went again for blood tes
    hbsag + 6600 iu/ml
    same other profile
    HBVdna undetected
    sgpt 38
    sgot 27

    so it is possible even if im taking interferon my hbsag is going up until my last test is going up.what is the meaning of all this result,do im improving for treatment.until now im taking interferon
    tnx god bless

    • I would discuss you results with your liver specialists. Serum levels of HBsAg can be a good marker used during PEG-IFN therapy. I would think you would prefer to see you HBsAg steadily declining while on PEG rather than cycling up and down. However it is good to see your HBV DNA at an undetectable level. Hopefully this response will be durable. I would encourage you to discuss your progress with your liver specialist.

  178. Hi,
    Recently i done one test. Test result is mentioned below( 0.41) , but none of them are saying weather i am having hepatitis B or not? Please help me.

    HEPATITIS B SURFACE @ |

    | ANTIBODY (Anti-HBs), |

    | SERUM 0.41 mIU/mL (< 10.00) |

    | (CMIA)

    • This test does not tell you if you have hepatitis B or not. It tells you that you do not have immunity to hepatitis B, which means you are not protected. Perhaps your doctor ran this test if you had received the HBV vaccine series and wanted to see if you had generated adequate immunity. You want to ask your doctor to run a hepatitis B panel or at a minimum, an HBsAg test. If you are HBsAg positive then you currently have an HBV infection. If you are HBsAg negative then you do not have HBV at this time. Keep in mind there is a 4-6 week window between a possible exposure to HBV and when you would test positive for HBV. Keep this in mind with the timing of your test.

  179. Hi I’m a lady of 29 yrs of age. In 2012 I was diagnosed with chronic hep B my viral load was 426 and now in 2014 my viral load is 105. What does this mean?

    • You seem to be in the inactive phase of the virus since your viral load is very low. I am assuming that you are HBeAg negative and that your ALT levels are below the upper limits of normal which is 19 IU/mL for women and 30 Iu/mL for men. If this is not the case then you should discuss your liver health with your liver specialist. It is unlikely you would benefit from any of today’s available treatments, but everyone benefits from regular monitoring of their HBV and liver health to be sure there are no changes over time. Also be sure to take good care of your liver by making healthy lifestyle choices such as: no alcohol, no smoking, avoid environmental toxins and be sure to maintain a healthy weight through a well balanced diet and regular exercise.

  180. I was diagnosed with HBV in January 2012.
    HbsAg positive
    Hbv Dna level were 13245829 IU/ml
    after two year of treatment witn entacavir HBv dna is now below detection limit in my blood.
    Now Hbeag is still reactive whereas Hbe-Ab are also present. what’s my stage how long i need the treatment.

    Thanks in Advance

    • This is an excellent response to entecavir! Unfortunately some people on antivirals do not seroconvert and lose HBeAg and gain the antibody. You will want to be sure to continue to take entecavir as directed by your doctor. It is very possible you will be on antiviral treatment for years. Please continue with regular monitoring of your HBV and liver health with your liver specialist.

      • My Alt level is slightly elevated I.e70
        I have been aske to perform the following test
        FBS. Cholesterol and Anti. HDV. And upper abdominal US

      • My reports are received today
        FBS is 94 mg/DL
        Cholesterol is 172 mg/DL
        Triglycerides 107 mg/dl
        Ultra sound is also normal .liver is normal in size with regular margins and subtle coarse texture. No focal mass is seen in the liver. Intra hepatic biliary ducts are not dilated. Portal vein appears normal measuring 0.9cm.
        Need Ur valuable comments

        • Your values appear to be in normal ranges, though there is evidence of liver disease noted as subtle coarse texture. Stopping use of entecavir would not be advised by any guidelines (AASLD, EASL, APSAL) at this time since you have not seroconverted and lost HBeAg and gained the antibody while remaining undetectable. Talk to your liver specialist, but I would continue to remain on entecavir and continue with regular monitoring. your ALT is elevated at 70 IU/mL (normal is under 30 IU/mL) as noted in a previous post, so I would make healthy lifestyle choices such as diet changes and adding regular exercise.

  181. hi.. my friend is hbsag positive is last year…his lft,usg abdomen is normal…his hbv dna is 730 …hbeag is negative….can u explain his exact condition…liver specialist said tht he is in inactive stage n need to have regular yearly check up..can he marry n have kids…

    • I would agree with your friend’s liver specialist. It sounds like your friend is in the inactive phase of the virus. He should continue with regular monitoring of his HBV and liver health. He should also be sure to take efforts to make healthy lifestyle choices that will positively impact his liver and general health. There is no reason your friend cannot get married and have children. There is a safe and effective vaccine to protect his future spouse from getting hepatitis B. It is a 3 shot series that take 6 months and prevents transmission. It is recommended that all babies get a birth dose of the HBV vaccine series followed by the other shots in the series according to schedule. Your friend should definitely have his children vaccinated and if he marries a woman with HBV, then the babies should also receive a birth dose of HBIG in order to prevent transmission. Don’t let HBV interfere with your friend living a full and happy life!

  182. I am 30 years male.I have come to know that iam hbsag recently when i have donated blood as i was not aware that iam hbsag +ve,the hospital people have called up and said that iam hbsag +ve and the report shown hbsag: 6123 COI….reference rane :reactive if >1.0COI and non reactive if <0.9 COI..I have no symptoms at all.

    Am i really a hbsag infected and what i should do further

    • It is not uncommon to learn of an HBV infection while donating blood since the blood is tested for HBV. Most with HBV have few or no notable symptoms. You want to see your doctor to learn more about your HBV. To start with you want to determine if you have an acute (new) HBV infection or a chronic infection. A person is considered chronically infected if they test HBsAg positive for greater than 6 months. If you have a chronic infection, you should try to see a liver specialist to learn more about your HBV and liver health.

  183. I’m a male aged 33 years old I’m a carrier of hepatitis B from birth I had a blood test and the result is:
    SGPT 56 IU/L
    SGOT 26 IU/L
    total Bilirubin 0.72 mg/dl
    Direct Bilirubin 0.36 mg/dl
    HBsAg 474.2 Negative
    HbeAg 0.4 Non-reactive
    Do I need medical help or any treatments?

    • I would encourage you to see a liver specialist to learn more about your HBV and liver health. You are currently HBeAg negative which typically indicates a less active phase of the virus, but you want to confirm by doing a HBV DNA test. Your ALT /SGPT is elevated with normal levels for men at or below 30 IU/mL, but without knowing more about your HBV, it is not clear if this is related to lifestyle changes or your HBV. Once again, i would encourage you to see a liver specialist just to learn more.

  184. Dear sir/madam
    what is reason for HBS Ag positive but HBV DNA viral load (Real time PCR) was not detected??

    • You are likely in an inactive phase of the virus. You are likely HBsAg +, HBsAb -, HBeAg -, HBeAb +, undetectable HBV DNA and normal liver function tests. Even though you are in the inactive phase of the virus, you still have chronic HBV and benefit from regular monitoring to be sure there are no changes. You also want to consider regular surveillance for liver cancer after the age of 40 years.

  185. Hi.. I just found out that I have chronic hepatits b..can you help me read my lab results please.
    HBsAG~reactive
    HBeAG~reactive
    ANTI HBe~non reactive
    ANTI HCV~non reactive
    SGPT~49 u/l
    DNA viral load test: Result: HBV DNA detected is greater than 110,000,000 IU/ml

    These are my results and it makes me loose hope. I hope somebody can enlighten me here. Thanks

    • I am sorry to hear of your chronic HBV diagnosis. You are currently HBeAg positive which indicates that you are in an active phase of the virus. Your HBV DNA is quite elevated and supports this and that you are very infectious at this time. Your SGPT/ALT is also elevated at 49 IU/mL. Men should be at or below 30 IU/mL and women at or below 19 IU/mL.

      I would encourage you to talk to your liver specialist about your results. It is likely that you might benefit from available treatments at this time such as an antiviral like tenofovir, but your doctor may wish to follow you a bit longer to track your HBV and liver health before making this decision. There are other things to consider such as age, family history and imaging results. Please don’t lose hope. There are good treatments to control your HBV if you and your doctor agree that you would benefit at this time.

      While you wait, please take care so you do not transmit HBV to others. HBV is transmitted through direct contact with blood and infected body fluids. This means you want to keep all open sores, bites, etc covered and be sure to practice safe sex or sex only with vaccinated partners. Take care to keep personal items, and keep them out of reach so items such as razors, toothbrushes, nail clippers, body jewelry etc. are not accidentally shared with others. HBV is not transmitted casually, but HBV does live outside the body for a week in trace amounts of dried blood etc. so be sure to clean up any accidental blood spills with a diluted bleach solution. Fortunately there is a safe and effective HBV vaccine. Sex partners, and close household members should be vaccinated to protect them from getting HBV.

      Be sure to also take care of you liver health. Please avoid alcohol. Alcohol and HBV are a dangerous mix. If you smoke, stop since smoking is an independent risk factor for liver cancer. Take care to be sure you maintain a healthy weight by eating a well balanced diet and getting regular exercise. Most importantly, get back to your doctor and discuss your results. Many with HBV live long full lives. Please do not lose hope.

  186. Hi,
    Recently a year back I came to know that I am hbsag positive,at that time doctor did some blood work dated 03/07/2013.
    HBV dna viral load -72 iu/ml
    SGPT 60.50 iu/ml normal should be 10-60 as per the reports
    Globulin 33.72 g/l normal should be 23-32 as per the reports
    Remaining LFT is normal in range
    HBEAG negitive
    Liver ultrasound scan is normal
    My liver specialist suggested me to do regular blood tests for every 6 months and HBV viral load for every 3 months once
    HBV dna viral load -162 iu/ml dated on 25th dec,2013
    Again I did my LFT dated 04/02/2014
    SGPT 62 u/l normal should be 0-50u/l as per the reports
    remaining came normal
    Liver ultrasound scan is normal
    Again I did my LFT dated 9/4/2014
    SGPT 52 iu/l normal should be upto 41 iu/l as per the reports
    Globulin 39.9 gm/l normal should be 23-35 gm/l as per the reports
    HBV Viral load 529 iu/l
    I checked with my liver specialist ,he suggested that I don’t need any treatment and I an a female 27yrs old.Can you please tell me your opinion in my case

    • Your viral load is low at 72 IU/mL and even 529 IU/mL so you would be considered in the inactive phase of the virus. I would agree that you would benefit from close monitoring of your HBV DNA and liver health, which is what your liver specialist is doing. If your HBV DNA continues to creep up with time then at some point you might benefit from today’s treatments, but likely not now. The concern would be your ALT/SGPT which is elevated. Normal levels are 19 IU/mL or lower for women and 30 IU/mL or less for men. Your globulins or proteins are also elevated. I would sit down and discuss these results with your liver specialist in order to try to determine what may be causing these elevated levels. On your own, you can take a look at your lifestyle and see if a change in diet and exercise can positively impact your liver function tests – particularly your ALT/SGPT. Perhaps you could make strict changes for 3 months and ask your doctor to repeat your ALT testing to see if there was a positive impact. Focus on eating a diet filled with fresh vegetables, fruits, whole grains and limited lean meats. Avoid processed foods and meats and fast foods. Avoid or cut back on refined sugars found in sodas and sweets. Always avoid alcohol, smoking and environmental toxins. Don’t forget to add regular exercise.

  187. hi! my sister(21 yrs old) is accidently diagnosed as inactive HBV carrier after blood donation three months back. HbsAg (+), HbeAg(-), AntiHbe(+), AntiHcv(-). viral load is 883 IU/ml. LFTs in normal range, USG of abdomen- normal. fibrosis scan normal. liver specialist says there is no need of treatment…only 6 month followup is required. we are really worried about her.is there anything that can be done to reduce it or manage it!.
    thankyou!

    • Your sister should continue with regular monitoring of her hepatitis B to be sure there are no changes to her HBV and liver health. At this time she would be considered to be in the inactive phase of the virus and likely not treated. However it is important to track her HBV DNA over time along with liver function tests, US and liver cancer screening with a simple AFP test. I would agree with your doctor about the time between monitoring.

      Please be sure that your sister avoids drinking alcohol. HBV and alcohol is a dangerous combination. Your sister should also take care with prescription and over the counter medications. For example, take care with acetaminophen (paracetamol), if she smokes, she should stop. Finally, it is important that you sister maintain a healthy weight by eating a well balanced diet and getting regular exercise. Fatty liver is becoming more common globally and no one wants to have 2 conditions impacting the liver, so it’s good to develop healthy eating habits.

      Also, I would encourage all family members to be screened for hepatitis B since it is more common among close, household contacts. Be sure close household contacts are vaccinated to protect against hepatitis B along with any sexual partners once they have been screened.

  188. Hi! I m Wangchuk and i was diagnosed as Heb B infected just three months before but i am not sure how long had been infected with the virus. I have carried out LFT and viral load test recently. And i am afraid that my result are all highly elevated. Followings are my test ALT level is 114 and viral load is 95488730 iu/ml. So, kindly help me or advise me what should i do. I met with the doctor but i am afraid that there is no expert liver specialist in our country. What kind of antiviral should i start and for how long the antiviral will not develop the rival resistance.

    • I would agree that you would benefit from seeing a liver specialist or a doctor with experience treating HBV. HBF has a directory of liver specialists, but it is not exhaustive and may not have experts from your country. You can look at http://www.hepb.org/resources/liver_specialist_directory.htm. If not I would consider looking to see if there is member organization that is part of the World Hepatitis Alliance that may have information about local resources. You can find membership and contact information at: http://www.worldhepatitisalliance.org/en/membership.html

      Not knowing all of your details I would still agree that you need to see a specialist and would likely benefit from treatment at this time. You are HBeAg positive with a high viral load and an elevated ALT which indicates you are in an active phase of the virus. You are likely in the immune clearance mode and hopefully will seroconvert and lose HBeAg and gain the HBeAb antibody. When a person moves into this inactive phase of the virus their viral load (HBV DNA) typically decreases significantly and their labs tend to normalize. The problem is whether or not your body will move into the inactive phase at this time or if it will cycle in and out resulting in liver damage. If you are looking at antivirals, I would encourage the use of a first line antiviral such as tenofovir or entecavir. These 2 drugs have excellent resistance profiles. Lamividine is much more affordable and available, but the resistance profile is poor. The problem with antivirals is that they need to be taken for years – some are on them for life. It is an important decision, so you want to discuss this with a doctor willing to work with you. Please note this link to guidelines used by Dr. Anna Lok. I like these guidelines since they combine guidelines from AASLD, EASL and APASAL. It’s a good place to start and you can read it and print it for your doctor Management of CHB – Lok Practice and How it relates to the guidelines http://www.natap.org/2014/HBV/011614_01.htm I also like the CME course (wonderful PDFs) that compare EASL and AASLD guidelines: CHB Treatment guideline navigator (no CME credit) based on both AASLD and EASL practice guidelines
      http://www.chbnavigator.com

      • Thank you so much for the guidelines. However, as my viral load is very high I am so afraid that my liver might fail at any time. But now a days I am seeing one gastrologist and he advised me to start taking tab entecavir but he is not sure about how much I have to take a day and he told me its about 0.5gm a day. So, I just want to seek your advise on how much I have to take per day with an ALT level of 111 and viral load 95488730 iu/ml

        I’m not understanding what is immune clearance mode. I would coud appreciate if you could kinldy explain me all these clrealy.

        • It is not the viral load that is usually as concerning, though it does become more of a concern if a person remains in the immune tolerant phase (high HBV DNA levels, normal ALT/AST) as the person ages – certainly 40 or above. the immune clearance mode is when the body is trying to clear the virus and move into a less active phase of the virus. During this phase, the viral load may go down, or cycle up and down, and while that is happening the ALT tends to go up and down. This up and down of the ALT referred to as flares when it is elevated is what results in damage to the liver. Your ALT is elevated at this time too (normal being 30 IU/mL or less), so I would agree with your liver specialist that you would likely benefit from treatment with an antiviral at this time. I am assuming this is a chronic infection, but you want to confirm this with your doctor. Entecavir is a very effective antiviral and is prescribed in .5mg tablets, 1 per day.

          • Thank you very much for info.

            Will there be any further treatment option if entecavir develops viral resistant. Actually doctor advised me to take one medicine called livosil and I dont know what does it do doctor also didnt tel me any about it. Over three weeks I m having some pain on right side exactly where liver is located and sometimes on my shoulder and backside also and the pain usually occurs in the evening. What is it?? is it due to liver damaging or what else please tel me …

            I also have a doubt that my abdomen is swollen, I talked regarding this with the Doctor also but he says that before the abdomen my leg will get swell. But I am pretty sure that my abdomen is looking different. So I just want to know that which part of the body abdomen or leg will first swell due to accumulation of ascetis or whatever. please help..

          • It looks like livosil is type of milk thistle supplement. It is not actual treatment for your HBV. There is no way for me to no the source of your abdominal and shoulder discomfort. You will need to talk to your liver specialist. Many people have no symptoms with their chronic HBV and others do. Since it may take decades for symptoms to occur and can reflect damage, you want to have your liver specialist address your concerns. If you have abdominal swelling you want to discuss this with your doctor as this is considered a more serious symptom. It is possible that you are worried and very sensitive to all symptoms you may be experiencing at this time, but it is certainly worth checking out with your doctor to confirm if your symptoms are related to your HBV or not.

  189. Hello am 35yrs old female diagnosed with chronic hbv with the following recent result:
    HBV Viral load: 4059 IU/ml
    GGPT: 24.0 IU/L (normal range 8.0 – 78.0)
    Bilirubin (Total): 0 48 mg/dl (normal range 0 – 1.0)
    Bilirubin (Direct): 0.10 mg/dl (normal range 0 -0.6)
    Bilirubin (Indirect): 0.38 mg/dl (normal range 0.10 – 1.00)
    SGOT : 20.4 U/L (normal range 0 – 40 )
    SGPT : 13.8 U/L (normal range 0 -40)
    Alkaline phosphatase: 58.0 IU/L (normal range 40 – 129)
    Total Proteins: 7.60 gm% (normal range 6.3 – 8.6)
    Albumin: 4.58 gm% (normal range 3.7 – 5.6)
    Globulin: 3.02 gm% (normal range 1.5 – 3.5)
    A/G Ratio: 1.5 (normal range 1.10 -2.20 )
    Kindly interpret and advise if I can commence treatment. Thank u.

    • Your liver enzymes are all within normal limits. Your ALT is within range which is particularly important. The normal range is 19 IU/mL or less for women. You do not mention if you are HBeAg positive or negative. I would discuss your results with your liver specialist. According to the guidelines it would not appear that you would benefit from treatment at this time, though you want to continue with regular monitoring to be sure your HBV DNA does not elevate or your ALT. Once again, whether or not you are HBeAg positive or negative makes a difference. Here are the guidelines I like to refer to from Dr. Lok since they compare AASLD, EASL and APASL. http://www.natap.org/2014/HBV/011614_01.htm

  190. Good day Sir,
    Sir I was infected with HBV about 4 years ago,I visited hepatalogist and after his advice I took adefovir about 1 year and entecair about 2 years and now my lab findings are as following HBV(DNA) by PCR non detected which was 9*104 (Now undetectable from previous 1.5 years and discontinuation of treatment), HBeab positive , all liver function tests are normal but HBsAg positive.

    • so your HBV DNA was at 90,000 – IU/mL or cp/ml? Now you have an undetectable viral load or is this your current viral load. If you seroconverted and lost HBeAg and gained the HBeAb antibody and you have had an undetectable viral load for a year or more, EASL suggests you can go off of the antiviral. However, you want to be sure your HBV DNA is tested regularly to be sure your viral load does not elevate, which can result in a rise in ALT (a flare) that can cause damage to the liver. You don’t want to wait to have symptoms. Just be sure you are monitored. I believe you are in a good place, but even where you are it is not too likely you will seroconvert and lose HBsAg and gain the antibody. This seroconversion process is what everyone wishes to achieve, but it does not happen to often spontaneously though does occur in 1-2% per year of those chronically infected.

  191. sir
    recently my blood is tested and its hbsag is positive iam really shocked why because iam not having any sexual contact with others and i didnt had any blood transactions also but still why it came i dont know i didnt get any symptoms also but still it is possitive

    • I am sorry to hear of your positive HBV test results. It is possible that you have a chronic infection and have had it since you were a baby or a child. HBV is very common in many parts of the world, and babies and young children are most vulnerable. That is why prevention through vaccination is so important. More often then not, most people have few or no obvious symptoms. Symptoms may not occur for decades, but it is best to learn as soon as possible so you can be sure to take care of your liver health. Be sure to talk to your doctor and retest to learn if you have a new or acute infection. A person is considered chronically infected if they test HBsAg positive for greater than 6 months. Until that time, please take care to not transmit HBV through direct contact with blood and body fluids. This includes taking care to cover open cuts, sore, bites etc. Be sure to practice safe sex with a condom or vaccinated sexual partners. Also take care with personal items such as razors, toothbrushes, nail clippers, body jewelry etc. that might have trace amounts of blood on them. Re-test, talk to your doctor about your results and if you learn you have a chronic infection then please consult with a liver specialist to learn more about your HBV and liver health. Take a deep breath and talk to your doctor.

  192. Anti HBc antibodies says Value=0.06 Unit is AI and Refrence Range is <10

    BHeAg Value is 0.42 Unit AI

    and the one which is scaring me is HBV DNA Quantitative PCR Value Detected abd lower limit of detection : 6IU/ml

    • I’m not sure of your units and your results. However if you have a viral load of 6 IU/mL you are certainly in the inactive phase of the virus, but if this is the range of the test then you may not even have it. Look at your test results to see if you are HBsAg positive or negative. If you are HBsAg positive then you currently have an HBV infection. If you are HBsAg negative, then most likely you do not have an HBV infection

  193. Sir
    I am HBsAG + since 2005. LFT are normal level. AST/ALT -23/18. HBeAg +, anti HBe – and HCV -. HBV DNA 12500 in Aug 2007, 0 in 2008 and now 41000, tested on 05 May 14. Can you suggest me what will possibilities now.

    Thank u.

    • Do you know if you are still HBeAg positive or negative? If you remain positive, it is just the fluctuation of the viral load. Hopefully your ALT continues to be 30 IU/mL or less. If you are currently HBeAg negative, it could be you have developed a mutation. I would talk to your liver specialist about your results so he can take a look at the whole picture to figure out what is going on with your HBV and if it is impacting your liver health.

  194. Hello Doctor
    I am 41 years old. I diagnosed hepatitis b last Sep in Korea. I am taking tenofovir 300mg every day now. But I blood work getting worse.
    Last Sep:
    AST-42 U/L
    ALT-41 U/L
    HBsAg Positive
    Ant HBs Negative
    HBeAg Negative
    AntiHBe negative
    HIV. Copies/ml-1230
    HIV IU/mL-360.7
    Apr 29,2014
    AST-99 U/L
    ALT-103 U/L
    Hepatitis B DNA copies/mL-<116
    Hepatitis B DNA IU/ L-<20
    Hepatitis B DNA log copies/mL-<2.06
    Hepatitis B DNA log IU/mL <1.30
    Reference range: Target Not Detected or <20 IU/mL
    Dynamic range 20-170.000.000IU/mL (116-989.400.000 copies/mL
    What is mean? Is my viral count is getting down? Should I still taking tenofovir?
    What also I should do for my liver, please? I do not have insurance. Help me…
    Thank you.

    • I am confused with your test results. Are you currently HIV positive too, or did you mis-type and you were telling me your previous viral load? Your viral load is very low at this time, but your ALT is elevated at 103 IU/mL. You did not mention if you are HBeAg positive or negative and it is imperative to know whether or not you are also coinfected with HIV, your HBe status etc. Perhaps it would be best if you email your situation to info@hepb.org. It’s difficult to review the comments if there is more than one set of comments

  195. viral load is 78 IU/mL
    DNA PCR LOG is 1.89
    what can I do?

    • You appear to be in an inactive phase of the virus. Your viral load is very low, which is very good. I would encourage you to continue with regular monitoring and talk to your liver specialist about regular liver cancer surveillance which is advised for everyone. Otherwise, be sure to take care with your liver health by ensuring you live a healthy lifestyle. Do not drink alcohol, avoid smoking and be sure to maintain a healthy weight by eating a well balanced diet and regular exercise. There are no currently available medications that would benefit you at this time, since most work by controlling the viral load. Once again, keep up with regular monitoring and take care with your liver health.

  196. Hi,
    Please I was diagnosed with hep b in feb 2012 and took a test later in may 2013. The results are as followes
    Anti Hbs 2.87 negative
    Anti HCV 0.098 negative
    Hbs Ag 0.545 negative.
    Please what does it mean? Does it mean I never fully recovered to become immune or does it mean I can still be chronically infected with the disease and may affect my liver later? Is this something I should worry abouut?
    I know the result is old and i would take another one tomorrow to see if the anti Hbs is still negative. Please let me know what these results mean. thanks.

    • It can take as long as 6 months to clear an acute (new infection). I would repeat testing to see if your surface antibodies increase. You do have some immune response, but most that recover from an acute infection tend to have a high anti-HBs titer following infection. It is possible you did not completely clear it and may have a smoldering, case. I would continue with monitoring to ensure there are no changes to your HBV serologies or your liver health. You can try to get a booster shot of the HBV vaccine, but that may not result in adequate titer generation. Please take care of your liver health and be sure to avoid alcohol which can be a dangerous combination with HBV. Be sure to maintain a healthy weight through diet and exercise. Definitely repeat testing.

  197. thank you for the info. I wanted to know how highly am I to infect some else with hep b what are the cautiousness?

    • It looks like your viral load is very low at 78 Iu/mL. You are not very infectious at this time at all though there is always some degree of risk. Also you need to be sure you are monitored regularly over time to be sure that your HBV and liver health do not change, because they can do that over time. At a future time you might be infectious. I would encourage you to have close household contacts and significant others and sexual partners vaccinated to be sure. One should always take precautions with blood – anyone’s blood. HBV is not the only disease out there. You want to be sure to avoid infection with other agents such as HIV or hepatitis C.

  198. Dear Sir
    My medical report is following…
    Anti HBe… negative
    HBeAg+ve
    SGPT 70 U/L (30-65 ul)
    DNA..52,90,000 IU/mL
    Please what does it mean? I am tottaly upset. I seem I will be gone away from this world. Pls explain asap.

    • It looks like you are currently in the active phase of the virus when your body is working hard to clear HBeAg and gain the antibody and move you into an inactive phase of the virus. At this time your ALT is elevated (normal ALT for men is 30 Iu/mL or less for men and 19 IU/mL or less for women) Your viral load is elevated. There is no need to panic, but you do want to talk to your liver specialist about your options at this time. You might well benefit from treatment at this time and will want to be carefully evaluated before this decision is made.

  199. Hi, my adopted son is diagnosed with chronic Hep.B last year. His latest blood tests are : HBeAg Positive. Viral load >1.7×10^8 IU/ML. Log equivalent of >8.23. OR
    9.89×10^8 copies/ml . >9.00 . AST 35U/L. ALT 26. U/L. ALP. 571 U/L. He is just 11 years old. Please can you advise me what can be done for him.

    • Has your son been evaluated by a pediatric liver specialist? It used to be that kids were typically not treated for their chronic HBV, the but thinking has changed over the years. There are some good clinical trial options for kids. I don’t know where you live, but they are worth looking into. Even if your son is not a good candidate for treatment there is a prospective cohort that is excellent and your child is very carefully monitored. Regular monitoring is so important. Here is a link to pediatric clinical trials. http://www.hepb.org/patients/hepatitis_b_clinical_trials.htm#pediatric The observational cohort is the HBRN. I would also advise you to consider joining the HBV Adoption and support list. It is a moderated list and parents share information about their kids, studies they may or may not be participating in, or are considering participation. Here is a link to join this group: https://groups.yahoo.com/neo/groups/hbv-adoption/info I think you will learn a lot from this group and it’s nice to talk to other parents that understand your concerns.

    • If you have additional questions about your son, please be sure to contact me at info@hepb.org

  200. i am 353yrs old,pls help me out my result are HBsAg positive HBeAg negative HBV DNA undetectable ultrasound result is normal LFT SGOT 17.7 SGPT 22.1 What is my life expectancy pls what is the next things to do.

    • You seem to be in the inactive phase of the virus since you are HBeAg negative and have an undetectable viral load. This is a good place to be. You have an ALT/SGPT of 22.1. Normal for men is 30 IU/mL or less, and for women 19 IU/mL or less. Once again this is certainly good -even if you are female and your ALT is 22 rather than 19 or under, and your ultrasound looks good. There is no way to predict how long a person will live. If you continue to monitor your HBV and take good care of your liver health then there is no reason to think you will not live a long, full life. It is not uncommon for someone with a chronic illness to die of something totally unrelated, so just do the best you can taking care of your liver and general health and enjoy your life!

  201. Dear Sir
    My Age.. 27 years
    Anti HBe… negative
    HBeAg+ve
    HbsAg+ve
    SGPT 70 U/L (30-65 ul)
    DNA..52,90,000 IU/mL 3,0787,800 copies/mL.
    Doctor priscribed me to eat a Tevinal 0.5 mg(entecavir) everyday. Aftet eating two days, I am gone so sick & have no energy in my body. Even I dont eat for vomitting. Always I fell vomitting & gas in my stomach. Please what does it mean? I am tottaly upset. Pls explain asap.

    • Looks like you are in the immune clearance phase of the virus. You are HBeAg positive, with a high viral load and elevated ALT (ALT should be below 30 IU/mL for men and 19 IU/mL for women). Entecavir is a good drug, but it is supposed to be taken on an empty stomach – 2 hours before and after a meal. There are not typically difficult side effects with entecavir, but you will want to check with your liver specialist or a GI doc with experience treating HBV. It’s possible it’s related to another GI problem. If it appears to be the entecavir, perhaps you can discuss the possibility of taking tenofovir?

  202. Now I have stopped antiviral Tedinol(0.5mg) & feelling same problem, espacially weakness, diziling & vomiting as well as gas problem. After sleeping time, I feel better mode & get energy.

    • Hopefully you discussed stopping the antiviral with your liver specialist. I think it’s important that you have your symptoms checked out with a GI doctor and/or your liver specialist. It may be totally unrelated to your HBV and something GI related, but you want to have it checked out. Try not to worry too much, but definitely get your symptoms checked out in case something has changed.

  203. Has the technology really improved that much? I was told that recent HBV DNA test can detect up to single digit IU/mL, meaning you can be reported 2 IU/mL on your HBV DNA.

    • It all depends on the sensitivity of the test being used. Many are very sensitive these days. Talk to your liver specialist and check the upper and lower limits of normal of the test for the lab being used.

  204. hlw doctor :)
    i m 22 years old and i am a chronic hepatitis b carrier …i have been taking medications since 2011…at first my viral load was 21023230 copies/ml. then i took my treatment with pegintron( injection) …one in every week for six months …after that my HBV DNA was around 100000 copies/ ml…then my doctor suggested me to take Entecavir .5 mg. i took it for 2 years and during this period i got undetectable (<176 IU/ml) three times. then my therapist told me to stop entecavir and check the virus load after 6 months. after 6 months when i checked, it was again detectable..HBV DNA was 1002 IU/mL. doctor told me to take medications again…but i didn't. then i checked for the HBV DNA viral load in the last month. it is high again…currently it is 18970 IU/mL.
    i am not taking any medications now.

    (December 2013)
    HBV DNA (quan. real time pcr) 1002 IU/mL
    HBeAg-Non reactive (.021)
    HBsag-Reactive (3.452)
    SGPT 22 U/L

    (April 2014)
    HBV DNA(quan. real time pcr) 18970 IU/mL
    HBeAg- Non reactive (.029)
    HBsAg-Reactive (3.886)
    SGPT 16 U/L

    so. can u please tell me what is my current physical condition? do i need to start medications right now?

    • I would follow the advise of your liver specialist. Your undetectable HBV DNA viral load was not durable or long lasting. You continue to need entecavir to control the virus, though at this time your ALT is not high, however you are now HBeAg negative and your viral load is quite high. I don’t think I would wait for an immune system flare despite your normal ALT. Please revisit with your liver specialist and restart your medication.

  205. Dear Sir
    I am 27 years old. I found hbsag+ve in 2005 first. Then after 3 months I checked, doctor advised me to not take any medicine that my viral was inactive. Recently my medical report is following:
    Anti HBe… negative, HBeAg+ve, HbsAg+ve
    SGPT 41 U/L ( normal upto 40 ul)
    SGOT 33U/L, ( normal upto 40 ul)
    Detected–DNA..53,80,000 IU/mL 3,0787,800 copies/mL.
    (Dynamic ragne: 6-1X10-8, Covesaion: 5.82)
    Will I take any medicine to remove virus? Is it possible to cure fully at this stage? Please advice me what can I do for live?

    • So I am not quite sure of your viral load because of the way you placed your commas in your viral load numbers. However you are currently HBeAg positive and you appear to have a high viral load. Your doctor likely considers you in the immune tolerant phase. However, your ALT is a bit elevated with a normal level for men at 30 IU/mL or less for men and 19 IU/mL or less for women. You want to consider if this is related to your HBV, or your liver health- which can be often be modified with diet and exercise and always avoiding alcohol. This is a discussion you really want to have with your liver specialist. As a person gets older and they remain in the immune tolerant stage, they reach a point where treatment with an antiviral might well be indicated. At this time there is no complete cure for HBV. The available medications work by controlling the replication of the virus. The problem is that a person many need to remain on these antivirals for years or even for life. It is a big decision, which is why you want to take a closer look with your liver specialist because it is a big treatment commitment at this time. Take a look at these guidelines and print and share them. The recommendations are not always crystal clear. if you are unsure you can always get a 2nd option, etc. http://www.natap.org/2014/HBV/011614_01.htm I like these because they compare AASLD, EASL and APASL. You might wish to talk to your specialist about shortening your monitoring schedule so you can get a better idea about your ALT and viral load, certainly your ALT since that is a less expensive test.

    • Please note that you are infectious at this time, so be sure to take precautions to prevent transmission to others. Please avoid direct contact of blood and infected body fluids with others. Be sure all sexual partners have been vaccinated or that you are practicing safe sex until they are protected through vaccination. Keep personal items such as razors, toothbrushes, body jewelry, nail clippers or anything that might have unseen traces of blood from others so they are not inadvertently shared. These are simple precautions that prevent transmission, though HBV is not casually transmitted hugging, sharing a meal, etc.

  206. sir, i am 23 year old..i had recently take my test report with hbsag reactiv >250iu/ml,aftr 1week my doctor order to test hbeag,anti hbe and hbv dna…the reports are hbeag non reactive,anti hbe reactiv 0.8516 and hbv dna quantve pcr 2901 viral copies/ml…can u tell me is there any chance to clear the virus?is it an acute or chronic infection?

    • A person is considered chronically infected if they test HBsAg positive for greater than 6 months. You can also ask your doctor to run an anti-HBc IgM test, which when positive typically indicates an acute infection. Determine first if you are acute or chronically infected. 90% of healthy adults newly infected with HBV will clear their infection while most that are chronically infected will not completely clear their infection. Regular monitoring will determine if they benefit from treatment. One step at a time – determine if you are acute or chronic and move on from there.

  207. Thank you for the sensible critique. Me &amp my neighbor were just preparing to do a little research about this. We got a grab a book from our local library but I think I learned more from this post. I am very glad to see such excellent info being shared freely out there. cekekddcdgff

  208. my mother age is 43.she is suffering from hepatitis b.her report show hepatitis b level 7.96.her test is done by elisa method.

    • I am assuming that your mother is chronically infected, which means that she has tested HBsAg positive for greater than 6 months. I would encourage you to have your mother evaluated by a liver specialist so you can learn more about her HBV and her liver health. There is no complete cure for chronic HBV at this time though there are good treatments to control and manage HBV if she learns she is a good candidate for treatment. That is why an evaluation by a liver specialist is so important.

  209. hi! i’m a seaman, chronic hep b patient,having treatment with entecavir for almost 2 yrs now.last two yrs ago,i was given by my physician with lamivudin but after being advice to stop for my HVB DNA viral load went down it viral load goes up again.after this, i was given by baraclud and respond quickly on my viral load to go down.being an ordinary seaman, i believe my work and food on board gives impact on my health,but this is the only ways and means of my medication.i also noticed that when i stop taking the meds, my viral load most likely will go up.i read your responses to others saying that it is unnecessary to take this meds since my viral loads are very low?before i join on this ship my doctor told me to continue my meds for 3 months,but since i have an idea from another doctor before that if you start to take this meds,it should be 3 yrs or so..? please give me some clarification and advice!THANK YOU!MAY GOD BLESS US ALL!

    • It is good that you are being carefully monitored and being treated with entecavir rather than lamivudine. Entecavir is much more potent than lamivudine and most patients soon develop resistance on lamivudine. It is true that most likely if you stop taking your antiviral, that your viral load will once again rebound possibly causing a flare. Your liver specialist may suggest going off of your antiviral if you have seroconverted and lost HBeAg and gained the antibody and have an undetectable viral load for some time. If this is suggested, you will need to be carefully monitored after you stop to see if your viral load rebounds, give it a few months and with the advice of your doctor, determine whether or not you need to remain on entecavir. However, perhaps the question you are asking is whether or not you should have ever started on an antiviral? That is not clear to me. If a person is in an inactive phase of the virus PRIOR to treatment, then they would likely not benefit from treatment. But if you were in an active phase and a good candidate for treatment at that time, then likely would need to remain on treatment unless your liver specialist feels it is safe to try stopping and carefully monitors you throughout the process to see if you can stop the antiviral. The idea of taking an antiviral for 3 months does not make sense and would likely result in viral rebound and possibly a flare noted with elevated ALT. I would plan on 3 years, but continue with regular monitoring. Hope that makes sense.

  210. I have tested positive for hbv last year! six month later when I rechecked the result is as follow!
    hbsag/negative
    hbsab/positive
    hbeag/negative
    hbeab/positive
    anti-hbc/positive
    LFT/normal
    total billirubin 0.7
    the doctor told me I recovered and get ride of the infection,
    I want to know am I still at risk of complication like cirohossi or liver cancer?
    will it reactivate in the future again?
    thank you for help

    • Congratulations. Sounds like you had an acute infection and that you resolved your infection. 90% of healthy adults newly infected with HBV will clear their infection without the need for medication or treatment. You do not need to worry about getting HBV again or transmitting it to others. In general there is no concern with reactivation in the future, but please be sure to inform your doctor if you are in need of long term immune suppressing drugs which can sometimes affect the immune system and reactivate the virus. In particular, drugs such as Rituximab for lymphoma and some drugs for the treatment of rheumatoid arthritis or psoriasis can result in reactivation, so you want to be sure to tell your doctor so you can be monitored, should you be in need of one of these drugs. Talk to your doctor and pharmacist. Otherwise, all is good! Take good care of your liver health!

  211. my dad hbeag is non reactive and anti hbeag is reactibve and hbv lade is 130000 lU/mL. so can his liver dises is cure?.

    • I am assuming that your Dad’s infection is a chronic infection? A person is considered chronically infected if they test HBsAg positive for greater than 6 months. For those that are chronically infected, there is no complete cure at this time, though there are good medications available that can manage and control the virus. For those that have an acute infection (newly infected) as a healthy adult, more than 90% will clear the infection on their own without the need for medication. Your dad needs to consult with a liver specials to learn more about his HBV and liver health. Most likely if he is chronically infected, he would be a good candidate for antiviral treatment.

  212. Hello
    I was diagnosed as having hepatitis B in 2002. Relative workup was done accordingly with hbeag negative and hbeab positive. PCR twicely done was negative with no copies/ml. Few days back I had pain in my right hypochondrium . I went for ultrasound who made me tense that I have fine coarse liver. So I started workup again . fibroscan was performed which showed no fibrosis. But PCR showed 7507 copies/ml . should I start medication? If then which one as I want to get rid of it completely plz kindly help and suggest something good for me thanks regards

    • sounds like you may be moving out of the inactive carrier state and progressing to the HBe negative hepatitis stage. This is not unusual, but should be closely monitored by your liver specialist. This is when the virus replicates in the absence of HBeAg. Normal ALT levels for men are 30 IU/mL or less, so yours appear to be elevated at this time. keep in mind that ALT may be elevated for reasons other than HBV, so you may wish to review previous results with your doctor to get a feel for whether or not this may be related to your HBV or other health issues. Looking at AASLD, APSAL, and EASL guidelines, you don’t necessarily require treatment at this time, though closer monitoring would be advised to see if elevated ALT and viral load is persistent. Should you and your liver specialist decide to treat, first line treatments such as tenofovir or entecavir may be suggested. They are both potent antivirals that control viral replication. Take a look and share this link with your doctor. http://www.natap.org/2014/HBV/011614_01.htm . I like it because it compares AASLD, APASL and EASL guidelines.

  213. My ALT is 57

    • took this into account with previous message. Normal ALT levels for men is 30 or less for men and 19 or less for women.

  214. Thanks really appreciated

  215. Hi, Iv been running series of test to start my in vitro fertilization, and in the last test for Hepatitis B, iv received the these results.
    HBsAg – negative
    HBsAg quantitive – <170.00 IU/ML , the normal range was not given
    Anti HBc Total – negative
    Anti HCV – negative
    Anti HBcll – nonreactive
    Anti HBe – nonreactive
    Anti HBs – nonreactive
    HAVAb IgG – reactive
    HAVAb IgM- nonreactive
    HbcAb IgM – nonreactive
    HBV DNA PRC – 4 626 copies/ml , used AMLICOR HBV monitor KIT, Roche
    Iv also received this blood results:
    ALT, AST, AP, LDH, AMY, GGI, OBI, IBIL, TBI , ALPI, TGL, LDI, CHOL, IRON, WBC, LYM, MID, GRAN, RBC, HGB, HCT, MCV, MCH, MCHC, RDW, PLT, MPV, PCT, PDW, LPCR, – normal range

    My doctor told me that I am contagious for other persons but I `m not ill and I don’t need any treatment. Can you please gave my some clarification of the results and some advice.
    Thanks, Ella.

    • Looks like you had a past HAV infection and you currently have a hepatitis B infection. I believe your HBV DNA is 4,626 cp/ml which is relatively low and would likely not be treated, though you don’t mention your ALT, though you say it is in range. Normal ALT levels for women are 19 IU/L or less which may differ from the upper limits of normal noted on your lab results. You appear to have a surface mutation since you are HBsAg negative, but still have a viral load. Certainly you should take simple precautions to prevent transmission and sexual partners should be vaccinated or you should practice safe sex. Keep open cuts etc. covered and avoid sharing personal items such as razors, toothbrushes, nail clippers, etc. HBV is transmitted as a result of direct contact with blood and body fluids. It may also be transmitted from an HBV positive mother to her baby. Please be sure you are carefully monitored – particularly when you are pregnant when fluctuations can occur. Please talk to your doctor about prophylaxis for your baby. Baby should get a birth dose of the HBV vaccine and a shot of HBIG within 12 hours of birth. The remainder of the vaccine series should be done according to schedule. I ask that you please be patient with responses.

  216. Hi, I’m from Malaysia. Currently waiting for my first appointment with liver specialist next month but cant help to feel worry about my condition based from the result I got, which I think is quite dangerous.

    Male
    ALT 132
    ALP 93
    HBV PCR – detected, 154889554 iu/ml (<– is this too high?)
    HbsAg Positive
    HbeAg positive
    HbeAb negative
    Autoimune antibody negative
    Ultrasound – no evidence of focal lesion within liver, gall bladder polyp

    what does this result tells me? I am really really worried now because lately I feel weird in my top right abdoment. is it because of hep B or gall bladder polyp? appreciate your reply

    • I would encourage you to take a deep breath and try to relax. I know it will feel like one month is a long wait, but HBV is rarely an emergency, even if it is a serious illness. I am assuming you have been diagnosed with a chronic HBV infection? A person is considered chronically infected when they test HBsAg positive for greater than 6 months. I will tell you that many people live long, full lives with chronic HBV. However, a good evaluation is very important, following your doctor’s advice and adopting a healthy lifestyle. Regular monitoring is also very important in case there are changes in your HBV status or liver health. Assuming you have a chronic infection, it looks like you are in the immune active phase since you have a high viral load and an elevated ALT. Normal ALTs are 30 IU/L or less for men and 19 IU/L or less for women. Your doctor may recommend treatment – likely with an antiviral such as tenofovir or entecavir. If you learn this is an acute infection, then it is unlikely that treatment will be needed. While you wait, be sure you do NOT drink alcohol. Alcohol and HBV are a dangerous combination. If you have a chronic infection you should not smoke. Eat a healthy diet and get regular exercise. Be sure to avoid transmission to others by avoiding direct contact with blood and body fluids. Fortunately HBV is vaccine preventable so be sure all partners and close, household contacts are screened for HBV and if they are negative, then they should be vaccinated to protect against HBV. HBV is quite prevalent in Malaysia. Take care not to share personal items such as razors, toothbrushes, nail clippers etc. and practice safe sex with unvaccinated partners. It’s possible there is a sensation of feeling at the top of your abdomen. The liver is surrounded by a sac with nerve endings that can become irritated if the liver is enlarged. Please confirm any results with your doctor.

      • thanks for your reply. i feel a bit relax now. yes, i was diagnosed with chronic hep b. i am worry because my late father died from liver chirossis (he never skipped taking specialist treatment and med too). And from my experience of taking care my father, all the symptoms he had are quite similar to what happened to me now. can you explain to me what is ‘immune active phase’? thanks so much

  217. hi im from philippines male 39, i need to know the status of my hbv profile, this are the result of my test.
    HBsAg – reactive 3530
    Anti-HBS – non reactive 2.0
    HBeAg – non reactive 0.098
    Anit-HBe – reactive 0.005
    Anti-Hbc – reactive 0.011

    do i need to take medication? im applying in KSA lately, upon my medical it appears that i have, hepa b reactive. it is curable? can i still work in the middle east with this condition? thank for the reply.

    • I am assuming you have a chronic infection ( you have tested HBsAg positive for greater than 6 months) At this time there is no treatment available that will completely cure HBV where the patient seroconverts losing HBsAg and gaining the antibody. There are good treatments to control or manage HBV, but you will need a more thorough evaluation to determine if you would benefit from treatment at this time. I would encourage you to consult with a liver specialist to learn more. He will want to run a viral load test, and liver function tests including ALT and AST and may also do an ultrasound of the liver to learn more. Unfortunately the Gulf Coast countries do not provide work permits and visas to those that test positive for HBsAg. It is unnecessary and unfair, but that is their policy.

      • is it already a chronic hep b, it was only tested last May 28, 2014. these few i feel joint pains, sleepy, slightly abdominal pain. how bad it is?

  218. Hep Be Antigen : Non Reactive (0.439)
    Hep Be Antibody : Reactive (0.185)
    HBV DNA : 69,705 IU/ml
    Hep E Virus IgM : Negative (S/CO 0.15)
    Hep A IgM : Negative (S/CO 0.64)
    HBs Ag : Positive
    Hep B Core Total Antibody : Positive (S/CO 7.57)
    LFT : i) Serum ALT : 550 U/I
    ii) Serum ALK Phosphatase : 330 U/I
    iii) Serum Bilirubin : 7.0 mg/dl

    Kindly guide keeping in view above mentioned detail that,
    i) Is it acute or chronic hep B ?
    ii) Is this shows i am a hep B carrier ? if no, how would i know about it ..
    iii) Should i start 6 months course of antibodies injections or not ?
    iv) Through which test would i know the percentage of damage done to my liver by hep B virus ?
    v) Will this affect my sexual power ?
    vi) Any other test you recommend ?
    An early response will be appreciated, please.

    • You might wish to run the anti-HBc IgM test, though this is not always definitive and may be positive if a chronically infected person is experiencing a significant flare rather than having an acute infection. You have a high viral load and your ALT is quite elevated at 550. A person is considered chronically infected if they test HBsAg positive for greater than 6 months. Hopefully you are being carefully monitored by a liver specialist or a physician with experience treating patients with hepatitis B. You would not benefit from HBIG or any type of HBV vaccine at this time. They do not benefit anyone already infected with the HBV virus. There is no way to tell at this time how much damage is being done to your liver without a liver biopsy or possibly a fibroscan. Even then you will not get specific percentages. If this is an acute infection, then hopefully it will clear. Your liver specialist will have a better idea since he has all of your information and has examined you directly. Hepatitis B will not affect your sexual power, but you are quite infectious at this time and need to take care with any sexual partners. Please be sure they are screened and if they are not HBV+ then they should be vaccinated to protect them. While they go through the 3 shot vaccination series, you need to be practicing safe sex. Please be sure to also take care by practicing simple precautions – covering open sores, cuts, etc, do not share personal items such as razors, toothbrushes, nail clippers, body jewelry or anything that may have trace amounts of blood on them. You should also practice safe sex unless your partners are vaccinated to protect against HBV. Please discuss your results with your liver specialist. If he feels it is a chronic HBV infection then you might well benefit from treatment at this time. Please discuss with an experienced liver specialist.

  219. Well, i have not done “anti-HBc IgM” and “anti-HBc IgG” tests yet, however, i was directly recommended to perform Anti HBc which resulted Positive (S/CO 7.57).
    Moreover, HBV viral load is 69,705 IU/ml as mentioned above.
    Kindly advise further..

    • anti-HBc total will be positive if you have a current or a resolved HBV infection. You want to run the anti-HBc Igm or IgG test to try to determine if you have an acute or chronic infection. However this test is not always definitive. sometimes a chronically infected person will show a positive anti-HBc IgM test when they are having a flare. Please discuss with your liver specialist.

  220. Hi, This is Paul. Would like to confirm about the test whether needed to be re-tested. My friend got tested 2 days ago and the result is <0.402 COI Unit and the result says Non- Reactive. My concern is should he test again just to confirm or it is safe to get vaccination. Your answer would be really helpful and appreciated. Thanks

    • Hi Paul. You mention the test result is non-reactive, but you did not say what test was run. I am assuming he had his surface antigen (HBsAg) tested? If your friend believes he may have had a recent exposure, he will want to consider that there is a 4-6 week window where a person will not test positive. Otherwise, in general, it is fine for him to get the vaccine.

  221. Yes, it is about HBV result. Result Shown below
    HBsAg – 0.402COI

    • oops… My answer still applies. Keep the 4-6 week window in mind if he believes he may have had a recent exposure. Otherwise proceed with vaccination

  222. test results 6 months before
    sgot 54U/L
    sgpt 53 U/L
    HBsAg 5560 reactive
    Anti-HCV 0.10 negative
    Anti-HBc 0.06 reactive
    Anti-HBs 21 mIU/mL antibody positive
    liver ultrasound normal
    current test results
    sgpt 95 U/L
    sgot 82 U/L
    liver ultrasound still normal
    HBE AG 0.112 (cutoff 1.000) nonreactive
    anti-Hbe 0.005 (cutoff 1.000) reactive
    HBV-DNA 266,833 IU/mL HBC DBA not detected
    What do my test results mean?

    • You have tested HBsAg positive for greater than 6 months so it appears that you have a chronic infection. Your ALT (SGPT) is elevated and on the rise. Normal ALT levels for women are 19 IU/mL or less for women and 30 IU/mL or less for men. Your AST levels are also elevated. It appears that your HBV is active and your immune system is responding at this time. Your HBV DNA is elevated at 266,833 Iu/mL, though I am not sure of your reference to HBC DBA? What I also find a bit unusual is that you are also HBsAb positive. I don’t know if you are seeing a liver specialist, but if not then you want a specialist to carefully evaluate your results. I would repeat testing in 3-4 months if possible, but definitely within 6 months. Ask your doctor to repeat the HBsAg, HBsAb (quantitative) and your HBV DNA along with your liver function tests (ALT/AST (SGPT/SGOT). Talk to your doctor about these previous results and your new results and ask if treatment is an option. Please take a look at and share this comparison of guidelines with your doctor. Management of CHB – Lok Practice and How it relates to the guidelines http://www.natap.org/2014/HBV/011614_01.htm

  223. I have been positive of Hepatitis B for about 13 years. before, I had over 200T copies of virus in my blood. ALT are high. since, I cannot afford the medication back then, against the advice of my doctor, I didn’t medicate. but I always see my doctor every 6 months for the past 12 years. Feb 2014, I went to have my checkup and blood work done. After a week, the nurse called and said that the lab results were good. I really didn’t mind, since the Dr. didn’t ask to see me for a follow up.
    4 weeks ago, I went to see my doctor gain for a check up and he discussed the previous lab results, In which he said, that he thinks my body is clearing the virus. but to be sure, he sent me for another blood work last 6/30/2014.

    Few weeks later, the nurse called and said that I’m HEP B negative. but the doctor wasn’t around to explain since he’s out on a vacation.

    I hope someone can explain to me about my latest lab result. I am very confused if my body really cleared the virus.
    here are the results:

    Hep Be Ag – negative
    Hep Be Ab – Positive
    HBsAg – Negative
    Hep B Surface Ab, Qual – Reactive

    AST 19 IU/L normal: 0-40
    ALT 26 IU/L normal: 0-44

    HBV IU/ml <20

    I wish someone can translate the test results for me.

    • Looks like you may be one of the lucky few that spontaneously seroconverts and loses HBsAg and gains the antibody. The only thing you want to confirm is the HBV DNA which you show as <20. This may be the lower limits of the test, which is what I am thinking. It would be nice to see “undetectable”. Please confirm with your doctor when he gets back from vacation. Don’t know if you’re male or female, but normal ALT levels for men are 30 IU/mL or less and for women 19 IU/mL or less.

  224. Hi,
    Im from India.My cousin sister was diagonsed with HBsAg positive.Now Current doctor had referred her to a liver specialist which will taken almost 2 week for appointment
    Test result shows like this(Elisa Method)
    HBsAg- value-2
    what does it mean

    • This result indicates that your cousin is currently infected with hepatitis B. It is very good that she is going to see a liver specials to learn more about her HBV and her liver health. Please do not worry that it will take her 2 weeks to get an appointment. HBV is rarely an emergency, so tell her not to panic. It is not unusual for HBV to be spread among close family members. Consider if others in the family may wish to be screened. If they do not have HBV, then they should be vaccinated. HBV is quite common in India so it’s good to be protected.

  225. Hi,

    I was diagnosed with Hepatitis B on a routine general medical checkup. The specialist told me that my liver function is normal and no medical treatment is required for this time bt i need to have a long term follow up check up to monitor my medical condition (liver).
    I would like to know if I have an active or passive virus, and if I am contagious? Based on my HBV DNA results:

    HBS Antigen -Positive
    HBc IgG Antibody – positive
    HBe Antigen – negative
    HBe Antibody – Positive

    alpha fetoprotein 1 ug/L
    SGPT/ALT 21 U/L
    SGOT/AST 34
    GT 13 U/L

    Hepatitis B Virus DNA Load : 13,465 IU/mL (4.13 log)
    Dynamic Linear Range : 20 (1.30 log) to 170,000,000 (8.23 log) IU/ML or
    116 (2.06 log) to 999,000,000 (9.00 log) copies/ml

    the essay detects all 8 hbv genotype a-h with equivalent efficiency.

    It would be much appreciated if you could explain me into details what does this result means especially my hbv dna result.

    thank you.

    • Looks like you have a HBeAg negative chronic HBV infection. Normal ALT for men is 30 IU/mL or less for men and 19 IU/mL or less for women. Yours looks pretty good which would indicate you are in a less active phase of the virus. The advice of your doctor to continue monitoring is good advice. He knows your other details and has likely done some imaging etc. Continue with regular monitoring as recommended and if something changes with your ALT, viral load etc. in the future than you can revisit with your doctor.

      I would encourage close household contacts/family members and sexual partners to be screened for hepatitis B. If they do not have HBV or have had a previous infection then they should be vaccinated to prevent transmission. Remember that HBV is not casually transmitted, but take care to avoid direct contact with blood, even trace amounts, and other infected body fluids. Just take care to not share personal items such as razors, toothbrushes, body jewelry, nail clippers or things that might have trace amounts of blood on them. Keep open cuts, sores etc. covered and practice safe sex if your partners are not protected through vaccination.

  226. hi!I Am Woman
    test results 6 months before
    HBE AG:negative
    sgot 33U/L
    sgpt 31U/L
    HBsAg 3183 reactive
    HBV Viral load : 5972 IU/m
    liver ultrasound normal
    current test results
    liver ultrasound normal
    liver Biopsy normal
    sgpt 18U/L
    sgot 17U/L
    HBV-DNA (Qunatitave) 180 IU/mL
    HBV DNA PCR :posetive
    What do my test results mean?what do you advise me on that case?Can i Pregnanant?
    Thanks really appreciated

    • Looks like you are HBeAg negative and in the inactive phase of the virus, which warrants continued monitoring, but likely not treatment at this time. As you can see, things do cycle up and down and change with time. You can certainly get pregnant, but be sure you talk to your doctor so that proper prophylaxis is available to baby within 12 hours of birth. Baby needs to receive a birth dose of the HBV vaccine and a shot of HBIG in order to prevent transmission. This is effective 90% of the time or more in preventing transmission from mother to baby. Be sure you are monitored during your pregnancy since it can affect your blood work. Be sure baby completes the HBV vaccine series according to schedule after the birth dose and shot of HBIG within 12 hours. Best of luck!

  227. Hi Hep
    Father is 74 years of age. Contracted hepb 10 years ago and is not on treatment
    Hbsag positive and Hbcab positive on blood test.
    Liver test is 100% normal
    Diagnosed asymptomatic carrier previous infection. Will you think he will ever need treatment as he is attempting to immigrate and one of the criteria is that HepB requiring virral treatment requires a medical waiver is he classed in this case

    • Monitoring of chronic HBV is very important because things can change with a person’s HBV and their liver health. So I cannot tell you if he will or will not ever require treatment. Many in the inactive phase never do. However, in the case of immigrating, I guess I would say that he is an asymptomatic carrier in the inactive phase. If he has to check the box for being HBsAg positive, then they may require additional information from his liver specialist, but I really do not know.

  228. Hi,

    I have been diagnosed HBSag Positive and HBEag Positive and got SGPT and SGOT levels as 35 and 28 respectively.
    HBV quantitative Viral load is 12,300 copies/ml.plasma (8200IU/ml).
    Should I be worried about Liver Cancer(Cirrhosis) or the condition is fine? Should I get married?

    • I am assuming you have a chronic infection and have tested HBsAg positive for greater than 6 months? If you have a chronic infection then you want to be sure you are carefully monitored by your liver specialist to determine if there are changes to your HBV or liver health that may warrant treatment. Those living with chronic HBV are at greater risk for liver damage (fibrosis or cirrhosis) and they are at greater risk for liver cancer which is another reason why regular monitoring is so important. That being said, many live very full lives with friends, love, family, careers and more. Follow your doctor’s advice, be sure all sexual partners are either vaccinated to protect against HBV or that you practice safe sex until they have completed the 3 shot series. Your ALT (SGPT) is a bit high. Normal levels for men are 30 Iu/mL or less for men and 19 IU/mL or less for women. Modify your diet to see if this makes a difference and of course never drink alcohol and don’t smoke. Repeat your SGPT after adhering to a very healthy diet and adding exercise after 3-4 months. Skip fast foods and processed foods, focus on eating plenty of vegetables, fruits, whole grains, limited lean meats, fish. Don’t eat too many foods with saturated fats. See if that brings your ALT into normal ranges. Discuss with your doctor.

  229. Hi Doctor,
    Below is my most recent lab result. Should I be worry and start on medication? Had liver biopsy done early this year before this lab, my liver specialist said result looks normal. Thanks.

    AST: 32
    ALT:31
    HBeAg: Negative
    HBsA: Positive
    HBeAb: Positive
    HBV DNA Real Time: 27630 IU
    HBV Log IU/mL: 4.44
    Bilirubin: 0.9
    Alkaline Phosphatase: 55
    Alpha-Fetoprotein: 12.3

    • It is good to discuss your test results with your liver specialist to learn more. You are HBeAg negative with an elevated HBV DNA for someone that is HBeAg negative. It appears that you have HBe negative hepatitis B, though your ALT is within normal ranges (less than 30 IU/mL) and your liver biopsy results look normal. Take a look and discuss this comparison of AASLD, EASL and APSAL guidelines http://www.natap.org/2014/HBV/011614_01.htm. It may help you as you monitor your results over time.

  230. Hi ,

    I am a 25 year old hepatitis b patient.i gave birth 4 months ago and my baby was only given shots after 24hrs because it was not in stock at birth.How effective is that.

    Worried mum

    • I’m afraid I don’t have statistics. Was your baby given a shot of HBIG? Hopefully your baby was able to get the first shot of the vaccine as soon as possible. Be sure baby continues with the series according to schedule. You will want to test your baby at the annual checkup.

  231. I’m a little confused!
    I was diagnosed with acute HBV (IgM Anti-HBc +) 3 months ago following the onset of typical symptoms. My Peak ALT was defined at 2607 following daily testing.

    In early August ALT started to increase again after subsiding to approx 600. This led to significant illness during the following weeks; jaundice and ultimately hospitalization. During this time (late August) ALT was recorded at near 5000 and HBV DNA 230 million IU/ml. Alt has decreased to 2500 after 10 days and jaundice has improved significantly. From latest round of tests Dr says that HBV is still in acute phase (IgM Anti-HBc +) and is not a co-infection of any sort.

    This bi-phasic pattern seems an unusual course for Acute HBV without co-infection? Can you shed any light on whats going on? Much appreciated!

    • I’m afraid I cannot shed any additional light on the subject. Occasionally, people are very seriously impacted by an acute HBV infection which can even result in liver failure. Wishing you the best with your recovery.

  232. My happetites b viral load result not detected .plz advi e for forther treatme t

    • It is good if you have an undetectable viral load. This would mean you are in an inactive phase of the virus and would not require treatment at this time. However, be sure to adopt a healthy lifestyle by making sure you maintain a healthy weight through diet and exercise and be sure to avoid alcohol and smoking. Please be sure you continue to be monitored by your liver specialist over time to be sure there are no changes to your HBV or liver health.

  233. Happettites c non reactive and hbsag b postive .hbsag viral load result not detected and liver function normal plz advice

  234. Hello Sir,
    I am Chronic HBV 34 year old patient, initially detected in 2005, Presently all lipid profiles/ LFT are normal/ in range. HBeAg – Negative, HBV DNA- 52000 IU/ml, (tested in Aug 14)
    Is there any requirement for antiviral drugs if yes for how much duration the course should be? Is there any possibility that HBV DNA count comes down by taking treatment of Yoga guru Baba Ramdev regularly?

    Does consumption of Non-veg/ oily foods add on to the load of Liver ?

    Thanks

    • There are algorithms for treatment of hepatitis B that you would want to discuss with your liver specialist. You mention that you have a normal ALT, but just want to confirm that your ALT is 30IU/L or less for men and 19 IU/L or less for women. You are HBeAg negative with an elevated HBV viral load, so you would benefit from a discussion regarding treatment with your liver specialist. Antivirals are very good at bringing down the HBV DNA and controlling the viral load, but they must be taken daily and cannot be abruptly stop. Many take antivirals for years or even for life. So it is best to adopt healthy lifestyle choices. The liver is involved in the digestion of the foods we eat. It is certainly good to cut back on oily, fatty foods and to also cut back on refined sugars, sodas and sweets. Focus on eating vegetables, fruits, whole grains and limited lean meats. I am not familiar with yoga guru ban Ramdev, but I doubt it will not lower the viral load. I hope you will discuss your situation with your liver specialist.

  235. Please could you assist me by interpreting the following Hepatitis B Viral Load Results to the understanding of a layman like me and also indicate whether or not treatment may be required:

    1. HBV DNA Copies increased from 1059 cp/mL in may 2013 to 28157 cp/mL in sept. 2014

    2. HEP B Virus DNA increased from 183 IU/mL in may 2013 to4838IU/mL in sept. 2014

    Thank you, in anticipation of you prompt feedback.

    • You will want to also consider some of your other results and also have a discussion with your liver specialist. For example are now or were you then HBeAg positive or negative? What does your ALT look like and is it increasing, or decreasing or generally the same? Normal ALT is less than 30 IU/L for men and 19 IU/L for women.

  236. I’m a little confused with your anti-HBc results. Are you anti-HBc IgM negative and anti-HBc IgG positive? If that is the case then it indicates that you have a chronic infection. I would encourage you to confirm this with your doctor. At this time your SGPT or ALT is elevated. Normal levels for men are under 30 IU/mL Keep in mind that ALT can be elevated for other reasons though it is also possible it is a result of your HBV. You do not mention your viral load which is typically run prior to recommending treatment. My recommendation would be to see a liver specialist first rather than later. Zeffix is lamivudine which is an antivirals. They work by suppressing the virus and are normally taken for long periods of time – years, and work to control the virus. I encourage you to see a liver specialist for a more thorough evaluation.

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